Are you over 60 and have depression? Try a medication that may help improve mood, thinking, and depression treatment in older adults!
Late-life depression is harder to treat and raises risks for memory loss and dementia. Team up to help us learn whether the medication, clemastine, can help improve mood, thinking, and response. Your participation may one day make antidepressant treatment work better!
Title: Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression
Description: Geriatric depression, also known as late-life depression, is a type of major depression that affects people who are 60 years old or older. It can be difficult to treat and often comes back after treatment. It can also lead to problems with memory and thinking. Some studies have found that problems with the white matter in the brain can make it harder to treat depression in older adults. White matter helps with communication in the brain. A new study suggests that a medicine called clemastine might be able to improve the white matter in the brain. Clemastine is usually used as an antihistamine, but it might also help the brain repair itself. The goal of this study is to find out if clemastine can make the white matter in the brain better in older adults with depression. The study will also determine whether this improvement can make antidepressant treatment work better, reduce depressive symptoms, and improve memory and thinking. The study will involve two groups of participants. One group will receive the standard antidepressant treatment along with a placebo, while the other group will receive the standard antidepressant treatment along with clemastine. The researchers will compare the effects of these two treatments over a period of 12 weeks. They will measure the improvement in white matter using special brain imaging techniques. They will also assess the participants' mood, memory, and thinking abilities, and keep track of any side effects or problems caused by the treatments. Overall, this study has the potential to contribute valuable insights into the treatment of geriatric depression, alleviate depressive symptoms, enhance cognitive function, and potentially open up new avenues for future research and therapeutic approaches.
Main inclusion criteria:
- Ages 60 and older
- Has depression
- Not on antidepressants
Online survey: https://healthresearch.ccts.uic.edu/studies/2024-0636
For questions about this study, contact:
Paresa Chowdhury
Telephone:773-669-2833
Email:pchowd3
uic [dot] edu
Children between 4–6 years old are needed for a paid research study
Dr. Tina Grieco-Calub, PhD, at the University of Illinois – Chicago, is conducting a research study that is studying how face masks impact children’s ability to learn new words.
Your child may be eligible if they:
- Are between 4 and 6 years of age.
- Are native English speakers.
- Have normal or corrected-to-normal vision.
- Have normal hearing.
- Have no history of hearing loss or current signs of ear infections or chronic middle ear problems.
- Have no history of cognitive, language, or global developmental delay.
Children who received speech-language services within the past 6 months are not eligible.
If you agree to participate you and/or your child will complete:
- Child and family questionnaires to determine your child’s eligibility for the study.
- Three study visits at the Institute for Juvenile Research (IJR) during which your child will complete cognitive and language assessments, and a word learning task. They will also receive a free hearing screening. Each study visit lasts approximately 30-45 minutes.
Families will be compensated up to $75 for their time. Free parking is available.
For more information or to see if your child is eligible, please fill out this survey and someone from our research team will reach out to you soon: https://redcap.link/wordlearning
ListenUP Research Collaborative
Study line: 312-355-2736
Email: listenupuic [dot] edu
CURB-2 Trial Open for Recruitment for Moderate/Heavy Cocaine Use Disorder Patients
Researchers at the University of Illinois Chicago are studying whether treatment with injectable extended-release naltrexone (XR-NTX; Vivitrol®) and injectable extended-release Buprenorphine (XR-BUP; Sublocade®) is safe and effective for helping people to cut down or stop using cocaine. Researchers believe the combination of these medications may reduce cocaine withdrawal symptoms.
The CURB-2 Study is a phase 2, randomized, placebo-controlled trial. Individuals may be eligible to participate if they:
- Are between the ages of 18 - 65
- Use cocaine regularly and interested in cutting down or stopping cocaine use
- Are able to attend in-person appointments on the UIC campus for approximately 16 weeks
There is no cost to participate in this study. The time and contribution of participants will be of tremendous value to public health research. Eligible individuals will be compensated up to a total of $968 for completed study activities.
Potential participants can call 312.355.4055 or follow the link below to learn more about the study and apply for potential participation:
https://redcap.link/curb2
Principal Investigator: Dr. Niranjan Karnik, Department of Psychiatry, UIC IRB Protocol #2022-0905
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Parents with 4-5 year old children are needed for a prevention of disruptive behavior research study
Parents with 4-5 year old children are needed for a prevention of disruptive behavior research study
Dr. Jennifer Suor (PhD) at the University of Illinois is conducting a study to see how a parenting intervention for the prevention of disruptive behavior disorders affects brain-behavior indicators of executive functioning and mental health in children receiving Medicaid.
You may be eligible if you:
- Have a child who is between the ages of 4 and 5 years old.
- Your child receives Medicaid
- You suspect your child might have difficulties with attention, problem-solving, and impulse control.
If you are eligible and agree to participate you and your child will complete:
- A virtual screening visit including psychiatric interviews and questionnaires.
- Two laboratory visits during which you and your child will complete some computer tasks while we measure your and your child’s brain waves. You and your child will also complete interaction tasks.
- Families will be randomly selected to participate in 12 session parenting group with other parents with 4-5 year old children (only parents participate).
- Two remote follow-up assessments over 12 months including interviews and questionnaires.
Children currently in talk therapy treatment or on medication for emotional or behavioral concerns might not be eligible. This study involves a time commitment of approximately 4 hours for children and up to 31 hours for parents who are randomly selected to participate in the parenting group therapy program.
Families will be compensated their time. All information you give is confidential.
For more information:
VISIT: https://redcap.link/projectepic
CALL: 312-355-3871
EMAIL: peacelabuic [dot] edu
Please specify that you are calling about Executive Function and Parenting in Childhood Research Study (Project EPIC)
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