This is an ongoing program of research to investigate the predictors of neurocognitive function and HIV Associated Neurocognitive Disorders (HAND) in HIV-infected women in the Women’s Interagency HIV Study (WIHS) Chicago Consortium. The WIHS is a multi-site prospective epidemiology cohort study of women who either are infected with HIV or are at increased risk for acquiring HIV infection. The WIHS is primarily funded by the National Institute of Allergy and Infectious Diseases (NIAID), with co-funding from the National Institute of Mental Health (NIMH), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Cancer Institute (NCI), and National Institute on Drug Abuse (NIDA).