Pinna Lab

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1. Fluoxetine: Pharmacology, Mechanisms of Action and Potential Side Effects. Nova Publishers. New York. (Editor: G. Pinna). 2014

2. Facilitating Resilience after Trauma: A Translational Approach. Nova Publishers. New York. (Editor: G. Pinna & T. Izumi). 2018

3. “Translational Methods for PTSD Research" in Neuromethods Series. Springer Nature. 2022


Allopregnanolone role in the neurobiology of stress and neuropsychiatric disorders”. Neurobiology of Stress. Special Issue. 2020

  1. Gunay A, and Pinna G. The novel rapid-acting neurosteroid-based antidepressant generation. Current Opinion in Endocrine and Metabolic Research. 2022
  2. Rasmusson AM, Novikov O, Brown KD, Pinna G, Pineles SL. Pleiotropic Endophenotypic and Phenotype Effects of GABAergic Neurosteroid Synthesis Deficiency in Posttraumatic Stress Disorder. Current Opinion in Endocrine and Metabolic Research. 2022
  3. Pinna G, Almeida FB, Davis JM. Allopregnanolone in post-partum depression. Frontiers in Global Women's Health. DOI: 10.3389/fgwh.2022.823616.
  4. Rasmusson AM, Pineles SL, Brown KD, Pinna G. A Role for Deficits in GABAergic Neurosteroids and their Metabolites with NMDA Receptor Antagonist Activity in the Pathophysiology of PTSD. J. Neuroendocrinology
  1. Wenzel ES, Pinna G, Eisenlohr-Moul T, Bernabe BP, Tallon RR, Nagelli U, Davis J, Maki PM. Neuroactive steroids and depression in early pregnancy. Psychoneuroendocrinology. 2021 Sep 24;134:105424. doi: 10.1016/j.psyneuen.2021.105424. Epub ahead of print. PMID: 34607173.
  2. Matrisciano F, Pinna G. PPAR-α Hypermethylation in the Hippocampus of Mice Exposed to Social Isolation Stress Is Associated with Enhanced Neuroinflammation and Aggressive Behavior. Int J Mol Sci. 2021 Oct 1;22(19):10678. doi: 10.3390/ijms221910678. PMID: 34639019; PMCID: PMC8509148
  3. Santovito LS, Pinna G. A case of reactivation of varicella–zoster virus after BNT162b2 vaccine second dose? Inflammation Research, 1-3. 2021
  4. Santovito LS, Pinna G. Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report. Inflamm Res. 2021 Jun 4:1–3. doi: 10.1007/s00011-021-01476-9. Epub ahead of print. PMID: 34086060; PMCID: PMC8176659.
  5. Almeida FB, Pinna G, Barros HMT. The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD. Int J Mol Sci. 2021 May 23;22(11):5495. doi: 10.3390/ijms22115495. PMID: 34071053
  6. Pinna G. Endocannabinoids and Precision Medicine for Mood Disorders and Suicide. Front Psychiatry. 2021 May 20;12:658433. doi: 10.3389/fpsyt.2021.658433. PMID: 34093274; PMCID: PMC8173054.
  7. Almeida FB, Barros HMT, Pinna G. Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD? Int J Mol Sci. 2021 Feb 10;22(4):1758. doi: 10.3390/ijms22041758. PMID: 33578758; PMCID: PMC7916492.
  8. Jacobson MH, Stein CR, Liu M, Ackerman MG, Blakemore JK, Long SE, Pinna G, Romay-Tallon R, Kannan K, Zhu H, Trasande L. Prenatal exposure to bisphenols and phthalates and postpartum depression: The role of neurosteroid hormone disruption. J Clin Endocrinol Metab. 2021 Apr 1:dgab199. doi: 10.1210/clinem/dgab199. Epub ahead of print. PMID: 33792735.
  9. Pinna G. Sex and COVID-19: A role for reproductive steroids. Trends in Endocrinology and Metabolism. (Media Release)
  1. Gatta E, Guidotti A, Saudagar V, Grayson GR, Aspesi D, Pandey SC, Pinna G. Epigenetic regulation of GABAergic neurotransmission and neurosteroid biosynthesis in alcohol use disorder. Int. J. Neuropsychopharmachology. doi: 10.1093/ijnp/pyaa073.
  2. Pinna G. Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievement. Neurobiology of Stress. Volume 13, November 2020, 100246 doi: 10.1016/j.ynstr.2020.100246
  3. Pineles SL, Nillni YI, Pinna G, Webb A, Arditte Hall KA, Fonda J, Irvine J, King M, Hauger R, Resick PA, Orr SP, & Rasmusson AM: Associations between PTSD-related extinction retention deficits and plasma steroids active at brain GABA-A and NMDA receptors. Neurobiology of Stress. 2020, 13, 100225. doi: 10.1016/j.ynstr.2020.100225
  4. Hamidovic A, Kapetyan K, Serdarevic F, Choi SH, Eisenlohr-Moul T, Pinna G. Higher circulating cortisol in the follicular vs. luteal phase of the menstrual cycle: a meta-analysis. Frontiers in Endocrinology. DOI: 10.3389/fendo.2020.00311
  5. Matrisciano F and Pinna G. PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression. Neurobiology of Stress 12:100222 DOI: 
  6. Kim BK, Fonda JR, Hauger RL, Pinna G, Anderson GM, Valovski IT, Rasmusson AM. Composite independent contributions of multiple CSF biomarkers to PTSD severity in men. Neurobiology of Stress 12:100220 DOI: 10.1016/j.ynstr.2020.100220
  7. Pinna G. Allopregnanolone, the neuromodulator turned therapeutic agent: Thank you, next? Front. Endocrinol. 11:236. doi: 10.3389/fendo.2020.00236
  8. Paul SM, Pinna G, Guidotti A: Allopregnanolone: From Molecular Pathophysiology to Therapeutics. A Historical Perspective. Neurobiology of Stress 12: 100215 DOI: 
  9. Tufano M and Pinna G: Role of PPARs in the treatment of neuropsychiatric disorders. Molecules. 25 (5) 2020 Feb 27. PMID: 32120979. DOI: 10.3390/molecules25051062
  10. Brymer KJ, Johnston J, Botterill JJ, Romay-Tallon R, Mitchell MA, Allen J, Pinna G, Caruncho HJ, Lisa E Kalynchuk Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm. Neuropsychopharmacology. 2020 Jan 11. doi: 10.1038/s41386-020-0609-z
  11. Kimball A, Dichtel LE, Nyer MB, Mischoulon D, Fisher LB, Cusin C, Dording CM, Trinh NH, Yeung A, Schorr M, Sung JC, Pinna G, Rasmusson AM, Carpenter LL, Fava M, Klibanski A, Miller KK: The neuroactive steroid allopregnanolone across the menstrual cycle and in menopause. Psychoneuroendocrinology. Volume 112, February 2020, 104512. doi: 10.1016/j.psyneuen.2019.104512.
  1. Pinna G: Animal models of PTSD: The socially isolated mouse and the biomarker role of allopregnanolone. Frontiers in Behavioral Neuroscience. 2019 Jun 11;13:114. DOI: 10.3389/fnbeh.2019.00114
  2. Raber J, Arzy S, Boulanger J, Depue B, LeDoux J, Lowry CA, Pinna G, et al.,: Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans. In “The Affectome Project”. Neuroscience & Biobehavioral Reviews. 2019. pii: S0149-7634(18)30642-0. doi: 10.1016/j.neubiorev.2019.03.015
  3. Locci A and Pinna G: Stimulation of PPAR-α by N-palmitoylethanolamine engages allopregnanolone biosynthesis to modulate emotional behavior. Biological Psychiatry. 85: 1036-1045. 2019.
  4. Aspesi D and Pinna G: Animal models of PTSD and novel treatment options. Behavioral Pharmacology 30:130-150. 2019.
  5. Locci A and Pinna G: Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options. Progress in Neuropsychopharmacology and Biological Psychiatry 92: 243-259. 2019.
  6. Rasmusson A, King A, Pineles S, Valovski I, Gregor K, Scioli-Salter E, Hamouda M, Nillni Y, Pinna G. Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD. Psychoneuroendocrinology. 102: 95-104. 2019.
  1. Aspesi D and Pinna G: Could a blood test for PTSD be on the horizon? Expert Review of Proteomics. 15: 983-1006. 2018 doi: 10.1080/14789450.2018.1544894.
  2. Pinna G. Biomarkers for PTSD at the interface of the endocannabinoid and neurosteroid axis. Frontiers in Neuroscience 12:482. 2018 doi: 10.3389/fnins.2018.00482
  3. Nisbett KE and Pinna G: Emerging therapeutic role of PPAR-alpha in cognition and emotions. Frontiers in Pharmacology. 2018. doi: 10.3389/fphar.2018.00998
  4. Pineles, S.L., Nillni, Y.I., Pinna, G., Irvine, J., Webb, A., Arditte Hall, K. A., Hauger, R.,Miller, M. W., Resick, P.A., Orr, S.P., & Rasmusson, A.M., PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone: confirmed in plasma. Psychoneuroendocrinology 93:133-141. 2018. doi: 10.1016/j.psyneuen.2018.04.024.
  5. Dichtel LE, Lawson EA, Schorr M, Meenaghan E, Paskal ML, Eddy KT, Pinna G, Nelson M, Rasmusson AM, Klibanski A, and Miller KK. Neuroactive steroids and affective symptoms in women across the weight spectrum. Neuropsychopharmacology 43:1436-1444. 2018. doi: 10.1038/npp.2017.269 (Media release).