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Mood Disorders and Suicide Research

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Expression and Methylation of HPA Axis Genes in Adult Suicide Brain

The goal of this project is to study the expression and methylation of genes related to HPA axis in postmortem brain of adult suicide victims and normal control subjects to determine if abnormalities in the HPA axis genes, of their methylation are associated with suicide.

Toll-like Receptors and Cytokines in Depression and Suicide Brain

The goal of this project is to study Toll-like receptors, cytokines and neuroimmune genes in the postmortem brain of normal controls, suicides victims and depressed subjects to determine if abnormalities of the immune function are involved in the pathophysiology of depression and suicide.

BDNF-Trk & Cytokines in Patients with Mood Disorders

To study neurobiological abnormalities in blood cells of adult patients with mood disorders. The goal of this project is to study if abnormalities in BDNF-MAP kinase signaling and cytokine levels are related to mood disorders.

PI and Wnt Signaling in Postmortem Brain of Bipolar and Schizophrenia Subjects

The major goal of this project is to study the role PI and Wnt signaling pathways, transcription factors and neurotrophins in postmortem brains of bipolar and schizophrenic patients.

PKC and Cellular Signaling in Suicide Brain

To examine the role of PKC and various components of phosphoinositide signaling pathway in the postmortem brains of teenage suicide subjects and to compare if these abnormalities are similar or dissimilar to adult suicide.

Serotonin Receptors and Cellular Signaling in Suicide Brain

To examine the role of serotonin receptor subtypes and various components of phosphoinositide signaling pathway to which these receptors are linked in the postmortem brains of teenage suicide subjects and to compare if these abnormalities are similar or dissimilar to adult suicide.

Serotonin Receptors and Protein Kinase C in Depression

The goal of this project was to study the role of serotonin receptors and the receptor-mediated signaling pathway in the pathophysiology of depression.

PKC Substrates & Transcription Factors in Mood Disorders

The goal of this project is to study the role of PKC and its substrates in platelets of patients with mood disorders.