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Dr. Subhash Pandey's Lab

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Epigenetic mechanisms of negative affective state of alcoholism

Alcohol dependence involves alterations in the allostatic state driven by negative emotional adaptations within the amygdaloid circuitry. This research component will investigate the role of specific isoforms of HDAC- and DNMT mediated epigenetic mechanisms in regulating the gene expression in the negative affective states of ethanol dependence.