Publications

Clinical Cognitive Affective Neuroscience Lab

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  1. Van Dyck, C.H., Malison, R.T., Seibyl, J.P., Laruelle, M., Klumpp, H., Zoghbi, S.S., Baldwin, R.M., Innis, R.B. (2000). Age-related decline in central serotonin transporter availability with [123I] ß-CIT SPECT. Neurobiology of Aging, 21, 497-501
  2. Staley, J.K., Van Dyck, C.H., Tan, P.Z., Tikriti, M.A., Ramsby, Q., Klumpp, H., Ng, C., Garg, P. Soufer, R., Baldwin, R.M., Innis, R.B. (2001). Comparison of [18F]Altanserin and [18F]Deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain:  Pharmacological studies. Nuclear Medicine and Biology, 28, 271-279
  3. Amir, N., Elias, J., Klumpp, H., Przeworski, A. (2003). Attentional bias to threat in social phobia: facilitated processing or difficulty disengaging attention from threat?  Behaviour Research and Therapy, 41, 1325-1335
  4. Amir, N., Klumpp, H., Elias, J., Bedwell, J. S., Yanasak, N., Miller, L.S. (2005). Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. Biological Psychiatry, 57, 975-981
  5. Klumpp, H., Amir, N., Garfinkel, S. (2009). False memory and obsessive compulsive symptoms. Depression and Anxiety, 26, 396-402
  6. Klumpp, H., Amir, N. (2009). Examination of vigilance and disengagement of threat in social anxiety with a probe detection task. Anxiety, Stress & Coping, 22, 283-296
  7. Shah, S.G., Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L. (2009). Amygdala and insula response to emotional images in generalized social anxiety disorder. Journal of Psychiatry and Neuroscience, 34, 296-302
  8. Amir, N., Beard, C., Taylor, C.T., Klumpp, H., Elias, J., Burns, M., Chen, X. (2009). Attention training in individuals with generalized social phobia: A randomized trial. Journal of Consulting and Clinical Psychology, 77, 961-973
  9. Klumpp, H., Deldin, P.J. (2010). Review of brain functioning in depression for semantic processing and verbal fluency. International Journal of Psychophysiology, 75, 77-85 
  10. Klumpp,H., Keller, J., Miller, G.A., Casas, B.R., Best, J.L., Deldin, P.J. (2010). Semantic processing of for emotional words in depression and schizophrenia. International Journal of Psychophysiology, 75, 211–215 
  11. Klumpp, H., Amir, N. (2010). Preliminary study of attention training to threat and neutral faces on anxious reactivity to a social stressor in social anxiety. Cognitive Therapy and Research, 34, 263-271
  12. Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L. (2010). Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: An event-related functional MRI study. Psychiatry Research: Neuroimaging, 183, 167-169
  13. Klumpp, H., Ho, S., Taylor, S.F., Phan, K.L., Abelson, J.L., Liberzon, I. (2011). Trait anxiety modulates anterior cingulate activation to threat interference. Depression and Anxiety, 28, 194-201
  14. Klumpp, H., Angstadt, M., Phan, K.L. (2012). Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological Psychology, 89, 273-276
  15. Klumpp, H., Angstadt, M., Phan, K.L. (2012). Shifting the focus of attention modulates amygdala and anterior cingulate cortex reactivity to emotional faces. Neuroscience Letters, 514, 210-213
  16. Prater, K.E., Hosanagar, A., Klumpp, H., Angstadt, M., Phan, K.L. (2013). Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depression and Anxiety, 30, 234-241
  17. Klumpp, H., Post, D., Angstadt, M., Fitzgerald, D.A., Phan, K.L. (2013). Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 3, 7
  18. Klumpp, H., Fitzgerald, D.A., Phan, K.L. (2013). Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 45, 83-91
  19. Klumpp, H., Fitzgerald, D.A., Cook, E., Shankman, S.A., Angstadt, M., Phan, K.L. (2014). Serotonin transporter gene alters insula activity to threat in social anxiety disorder. NeuroReport, 25, 926-931
  20. Swartz, J.R., Phan, K.L., Angstadt, M., Klumpp, H., Fitzgerald, K.D., Monk, C.S. (2014). Altered activation of the rostral anterior cingulate cortex in the context of emotional face distractors in children and adolescents with anxiety. Depression and Anxiety, 31, 870-9
  21. Wheaton, M.G., Fitzgerald, D.A., Phan, K.L., Klumpp, H. (2014). Perceptual load modulates anterior cingulate cortex response to threat distractors in generalized social anxiety disorder. Biological Psychology, 101, 13-7
  22. Klumpp, H., Fitzgerald, D.A., Angstadt, M., Post, D., Phan, K.L. (2014). Neural response during attentional control and emotion processing predicts improvement after cognitive behavioral therapy in generalized social anxiety disorder. Psychological Medicine, 44, 3109-21
  23. Klumpp, H., Keutmann, M.K., Fitzgerald, D.A., Shankman, S.A., Phan, K.L. (2014). Resting state amygdala prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 4, 14
  24. Nelson, B.D., Fitzgerald, D.A., Klumpp, H., Shankman, S.A., & Phan, K.L. (2015). Prefrontal engagement by cognitive reappraisal of negative faces. Behavioural Brain Research, 279, 218-25 
  25. Gentili, C., Cristea, I.A., Angstadt, M., Klumpp, H., Tozzi, L., Phan, K.L., Pietrini, P. (2016). Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety. Experimental Biology and Medicine, 241, 225-37
  26. DiGangi, J.A., Tadayyon, A., Fitzgerald, D.A., Rabinak, C.A., Kennedy, A., Klumpp, H., Rauch, S.A., Phan, K.L. (2016). Reduced default mode network connectivity following combat trauma. Neuroscience Letters, 615, 37-43
  27. Wu, M., Kujawa, A., Lu, L.H., Fitzgerald, D.A., Klumpp, H., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2016). Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Human Brain Mapping, 37, 1684-95
  28. Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., & Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine, 46, 1055-67
  29. Klumpp, H., Fitzgerald, D.A., Piejko, K., Roberts, J., Kennedy, A.E., Phan, K.L. (2016). Prefrontal control and predictors of cognitive behavioral therapy response in social anxiety disorder. Social Cognitive and Affective Neuroscience, 11, 630-40
  30. Kujawa, A., Wu, M., Klumpp, H., Pine, D.S., Swain, J.E., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2016). Altered development of amygdala-frontal connectivity during emotional face processing in anxious youth and young adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1, 345-52
  31. Burkhouse, K.L., Kujawa, A., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Phan, K.L., Klumpp, H. (2016). Neural reactivity to reward as a predictor of cognitive behavioral therapy response in anxiety and depression. Depression and Anxiety, 33, 281-8
  32. Yao, B., Sripada, R.K., Klumpp, H., Abelson, J.L., Muzik, M., Zhao, Z., Rosenblum, K., Briggs, H., Kaston, M., Warren, R. (2016). Penn State Worry Questionnaire – 10: A new tool for measurement-based care. Psychiatry Research, 239, 62-7
  33. Crane, N.A., Jenkins, L.M., Dion, C., Meyers, K.K., Weldon, A.L., Gabriel, L.B., Walker, S.J., Hsu, D.T., Noll, D.C., Klumpp, H., Phan, K.L., Zubieta, J-K., & Langenecker, S.A. (2016). Comorbid anxiety increases cognitive control activation in major depressive disorder. Depression and Anxiety, 33, 967-77
  34. Xing, M., Tadayonnejad, R., MacNamara, A., Ajilore, O., Phan, K.L., Klumpp, H., Leow, A (2016). EEG based functional connectivity reflects cognitive load during emotion regulation. IEEE International Symposium on Biomedical Imaging (ISBI), 771-774
  35. Kujawa, A., Weinberg, A., Bunford, N., Fitzgerald, K.D., Hanna, G.L., Monk, C.S., Kennedy, A.E., Klumpp, H., Hajcak, G., Phan, K.L. (2016). Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 71, 162-8
  36. Stange, J.P., MacNamara, A., Barnas, O., Kennedy, A.E., Hajcak, G., Phan, K.L., Klumpp, H. (2016). Neural markers of attention to aversive pictures predict response to cognitive behavioral therapy in anxiety and depression. Biological Psychology, 123, 269-277.
  37. Tadayonnejad, R., Klumpp, H., Ajilore, O., Leow, A., Phan, K.L. (2016). Aberrant pulvinar effective connectivity in generalized social anxiety disorder. Medicine, 95(45):e5358
  38. Xing, M., Tadayonnejad, R., MacNamara, A., Ajilore, O., DiGangi, J., Phan, K.L., Leow, A., Klumpp, H. (2016). Resting-state theta band connectivity and graph analysis in generalized social anxiety disorder. NeuroImage: Clinical, 13, 24-32.
  39. Klumpp, H., Roberts, J., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Gross, J.J., Phan, K.L. (2017). Emotion regulation related neural predictors of cognitive behavioral therapy response in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 75, 106-112
  40. Burkhouse, K.L., Kujawa, A., Klumpp, H., Fitzgerald, K.D., Monk, C.S., & Phan, K.L. (2017). Neural correlates of explicit and implicit emotion processing in relation to treatment response in pediatric anxiety. Journal of Child Psychology and Psychiatry, 58, 546-554
  41. Burkhouse, K.L., Kujawa, A., Keenan, K., Klumpp, H., Fitzgerald, K.D., Monk, C.S., & Phan, K.L. (2017). The relation between parent depressive symptoms and neural correlates of attentional control in offspring: A preliminary study. Psychiatry Research, 263, 26-31
  42. Fitzgerald, J.M, Phan, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Klumpp, H. (2017). Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder. Journal of Affective Disorders, 218, 398-406
  43. Bunford, N., Kinney, K.L., Michael, J., Klumpp, H. (2017). Threat distractor and perceptual load modulate test-retest reliability of anterior cingulate cortex response. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 77, 120-127
  44. Bunford, N., Roberts, J., Kennedy, A.E., Klumpp, H. (2017). Neurofunctional correlates of behavioral inhibition system sensitivity during attentional control are modulated by perceptual load. Biological Psychology, 127, 10-17
  45. Klumpp, H., Fitzgerald, J.M., Kinney, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Phan, K.L. (2017). Predicting cognitive behavioral therapy response in social anxiety disorder with anterior cingulate cortex and amygdala during emotion regulation. NeuroImage: Clinical, 15, 25-34
  46. MacNamara, A., Klumpp, H., Kennedy, A.E., Langenecker, S.A., Phan, K.L. (2017). Transdiagnostic neural correlates of affective face processing in anxiety and depression. Depression and Anxiety, 34, 621-631
  47. Klumpp, H., Roberts, J., Kapella, M.C., Kennedy, A.E., Kumar, A., Phan, K.L. (2017). Subjective and objective sleep quality modulate emotion regulatory brain function in anxiety and depression. Depression and Anxiety, 34, 651-660
  48. Gorka, S.M., Lieberman, L., Klumpp, H., Kinney, K., Kennedy, A., Ajilore, O., Francis, J., Duffecy, J., Craske, M., Nathan, J., Langenecker, S., Shankman, S.A., & Phan, K.L. (2017). Reactivity to unpredictable threat as a treatment target for fear-based anxiety disorders. Psychological Medicine, 47, 2450-2460
  49. Bas-Hoogendam, J.M., et al. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical, 16, 678-688
  50. Stange, J.P., Kennedy, A.E., Hajcak, G., Phan, K.L., Klumpp, H. (2017). Brain-behavioral adaptability predicts response to cognitive behavioral therapy for emotional disorders: A person-centered event-related potential study. Neuropsychologia
  51. Klumpp, H., Shankman, S.A. (2018). Using event-related potentials and startle to evaluate time course in anxiety and depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 10-18
  52. Stange, J.P., Jenkins, L.M., Hamlat, E.J., Bessette, K.L., DelDonno, S., Kling, L.R., Passarotti, A.M., Phan, K.L., Klumpp, H., Ryan, K.A., & Langenecker, S.A. (2018). Disrupted engagement of networks supporting hot and cold cognition in remitted major depressive disorder. Journal of Affective Disorders, 227, 183-191
  53. Klumpp, H., Bhaumik, R., Kinney, K.L., Fitzgerald, J.M. (2018). Principal component analysis and neural predictors of emotion regulation. Behavioural Brain Research, 338, 128-133
  54. Gorka, S.M., Burkhouse, K.L., Klumpp, H., Kennedy, A.E., Afshar, K., Francis, J., Ajilore, O., Mariouw S., Craske, M.G., Langenecker, S., Shankman, S.A., Phan, K.L. (2018). Error-related brain activity as a treatment moderator and index of symptom change during cognitive-behavioral therapy or selective serotonin reuptake inhibitors. Neuropsychopharmacology, 43, 1355-1363
  55. Langenecker, S.A., Crane, N.A., Jenkins, L.M., Phan, K.L., Klumpp, H. (2018). Pathways to neuroprediction: Opportunities and challenges to prediction of treatment response in depression. Current Behavioral Neuroscience Reports, 5, 48-60
  56. Burkhouse, K.L., Kujawa, A., Hosseini, B., Klumpp, H., Fitzgerald, K. D., Langenecker, S.A., Monk, C.S., Phan, K.L. (2018). Anterior cingulate activation to implicit threat before and after treatment for pediatric anxiety disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, 84, 250-256
  57. Klumpp, H., Kinney, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Kumar, A., Phan, K.L. (2018). Trait attentional control modulates neurofunctional response to threat distractors in anxiety and depression. Journal of Psychiatric Research, 102, 87-95
  58. Klumpp, H., Hosseini, B., Phan, K.L. (2018). Self-reported sleep quality modulates amygdala resting-state functional connectivity in anxiety and depression Frontiers in Psychiatry, 9, 220
  59. Xing, M., GadElkarim, J., Ajilore, O., Wolfson, O., Forbes, A., Phan, K.L., Klumpp, H., Leow, A. (2018). Thought Chart: tracking the thought with manifold learning during emotion regulation. Brain Informatics 5:7
  60. Hixson, H., Burkhouse, K.L., Gorka, S.M., Klumpp, H. (2018). A preliminary examination of the relation between neural sensitivity to reward and history of alcohol use disorder among adults with internalizing psychopathologies. Neuroscience Letters, 690, 17-22
  61. Burkhouse, K.L., Gorka, S.M., Klumpp, H., Kennedy, A.E., Karich, S., Francis, J., Ajilore, O., Craske, M.G., Langenecker, S.A., Shankman, S.A., Hajcak, G., Phan, K.L. (2018). Neural responsiveness to reward as an index of depressive symptom change following cognitive-behavioral therapy and SSRI treatment. Journal of Clinical Psychiatry, 79(4)
  62. Fitzgerald J., Kinney, K.L., Phan, K.L., Klumpp, H. (2018). Distinct neural engagement during implicit and explicit regulation of negative stimuli. Neuropsychologia
  63. Klumpp, H., Fitzgerald J. (2018). Neuroimaging predictors and mechanisms of treatment response in social anxiety disorder: an overview of the amygdala. Current Psychiatry Reports 20:89
  64. Xing, M., Lee, H., Morrissey, Z., Chung, M.K., Phan, K.L., Klumpp, H., Leow, A., Ajilore, O. (2019). Altered dynamic electroencephalography connectome phase-space features of emotion regulation in social anxiety. NeuroImage, 186, 338-349
  65. Langenecker, S.A., Klumpp, H., Peters, A.T., Crane, N.A., DelDonno, S.R., Bessette, K.L.,
  66. Ajilore, O., Leow, A., Shankman, S.A., Walker, S.J., Ransom, M.T., Hsu, D.T., Phan, K.L., Zubieta, J-K., Mickey, B.J., Stange, J.P. (2019). Multidimensional imaging techniques for prediction of treatment response in major depressive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 91, 38-48
  67. Klumpp, H., Kinney, K.L., Bhaumik, R., Fitzgerald, J.M. (2019). Principal component analysis and brain-based predictors of emotion regulation in anxiety and depression. Psychological Medicine, 49, 2320-2329
  68. Fitzgerald, J.M., Klumpp, H., Langenecker, S., Phan, K.L. (2019). Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression. Depression and Anxiety, 36, 453-464
  69. Kinney, K.L., Burkhouse, K.L., Klumpp, H. (2019). Self-report and neurophysiological indicators of emotion processing and emotion regulation in social anxiety disorder. Biological Psychology, 142, 126-131
  70. Gorka, S.M., Young, C., Klumpp, H., Kennedy, A.E., Francis, J., Ajilore, O., Langenecker, S., Shankman, S.A., Craske, M.G., Stein, M., Phan, K.L. (2019). Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: A randomized trial. Neuropsychopharmacology, 44, 1639-1648
  71. Jayakar, R., Tone, E.B., Crosson, B., Turner, J.A., Anderson, P.L., Phan, K.L., Klumpp, H. (2020). Amygdala volume and social anxiety symptom severity: Does segmentation technique matter?  Psychiatry Research: Neuroimaging, 295, 111006 
  72. Burkhouse, K.L., Jimmy, J., Defelice, N., Klumpp, H., Ajilore, O., Hosseini, B., Fitzgerald, K.D., Monk, C.S., & Phan, K.L. (2020). Nucleus accumbens volume as a predictor of anxiety symptom improvement following CBT and SSRI treatment in two independent samples. Neuropsychopharmacology, 45, 561-569
  73. Marin, M.F, Hammoud, M.Z., Klumpp, H., Simon, N.M., Milad, M.R. (in press). Multimodal categorical and dimensional study of threat conditioning and its extinction in anxious individuals. JAMA Psychiatry
  74. Xing, M., Fitzgerald J., Klumpp, H. (in press). Classification of social anxiety disorder with support vector machine analysis using neural correlates of social signals of threat. Frontiers Psychiatry Neuroimaging and Stimulation