Our Research

Clinical Cognitive Affective Neuroscience Lab

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Assessing an electroencephalography (EEG) biomarker of response to transcranial magnetic stimulation for major depression

T01 CX002088-03

This study uses EEG to identify biomarkers of response and mechanisms of change as they relate to transcranial magnetic stimulation targeting dorsolateral prefrontal cortex in Veterans with treatment-resistant depression.

Dr. Klumpp's Role: Site Co-Investigator at Edward Hines, Jr. VA Hospital, IL

Gaze-Contingent Music Reward Therapy for Social Anxiety

R33 MH116089-03      NIH/NIMH

The study proposes to modify attentional bias by reinforcing attention to non-threat faces with reward (music) while training attention away from threat faces. The R33 randomized trial will test whether change in attention is associated with clinical improvement.


Passive, Mobile Assessment of Sleep, Circadian Timing, and Keyboard Dynamics to Prospectively Predict Depression Severity, Cognition, Emotion Processing, and Emotion Regulation

R21 MH121852-01

This study combines actigraphy with the smartphone app ‘BiAffect’ to understand digital behaviors, sleep, and circadian patterns on cognitive function and emotion processing in individuals with major depressive disorder or insomnia. 

Morning Light Treatment for Traumatic Stress: the Role of Amygdala Reactivity

R61 MH117157-02   NIH/NIMH

Morning bright light treatment is a promising intervention for posttraumatic stress disorder. The study evaluates links between morning light treatment over the course of 4 weeks and mechanisms of symptom improvement. 

Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy

R01 MH112705-01  NIH/NIMH

The study examined mechanisms of change that underlie CBT, and identify predictors of CBT response, in patients with major depressive disorder or social anxiety disorder.

Gaze-Contingent Music Reward Therapy for Social Anxiety

R61 MH116089-01     NIH/NIMH

The study modifies attentional bias by reinforcing attention to non-threat faces with reward (music) while training attention away from threat faces.  The long-term objective is to test whether such attentional bias modification improves social anxiety symptoms and quality of life.

Behavioral and Neurophysiological Assessment of Hot and Cold Memory and Executive Function in Treated Breast Cancer Patients

University of Illinois Chicago       Center for Clinical and Translational Science Pilot Grant

The study examined links between chemotherapy and/or hormone therapy with neurocognitive performance and brain response (i.e., EEG/event-related potentials) in females with breast cancer to understand the impact of treatment on cognitive deficiencies.  

Effects of THC on Retention of Memory for Fear Extinction Learning in PTSD

R61 MH111935-01    NIH/NIMH

Trauma-focused psychotherapy is first-line psychotherapy for posttraumatic stress disorder (PTSD) and is believed to work through fear extinction mechanisms.  While generally effective, many remain symptomatic after treatment.  Animal studies have shown that activation of the cannabinoid system during extinction learning enhances fear extinction and its retention. Specifically, CB1 receptor agonists, such as Δ9-tetrahydrocannibinol (THC), can facilitate extinction recall by preventing recovery of extinguished fear in rats. This aim of this study is to use Δ9-tetrahydrocannibinol to increase retention of fear extinction in PTSD to improve clinical outcome.

Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment

R01 MH101497-01    NIH/NIMH

The project examined the impact of selective serotonin reuptake inhibitors and cognitive behavioral therapy on negative valence systems (NVS) constructs, particularly the Fronto-Limbic Affect Regulation and Emotional Salience brain circuit, and to elucidate whether NVS constructs at pre-treatment predicts 
treatment response across internalizing psychopathologies.

Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety Disorder

K23 MH093679-01A2      NIH/NIMH

In the context of Cognitive Behavioral Therapy, the project proposes to perform pre- and post-treatment functional MRI of limbic-prefrontal circuitry in patients with social anxiety disorder to examine brain markers of response to therapy and treatment-related brain changes. 

Identification of Neural Predictors of Response to Cognitive Behavioral Therapy in Depression and Anxiety

Brain & Behavior Research Foundation (formerly NARSAD)

The objective of this study is to broaden the clinical impact of an existing NIMH-funded K23 Career

Development Award project by including individuals with major depressive disorder.  The project involves longitudinal fMRI and EEG measures of socio-emotional processing and emotion regulation before and after CBT.

Sleep Disturbance in Mood Disorders Across the Lifespan

Campus Research Board   Pilot Grant   OVCR Research Development Services, University of Illinois Chicago, Chicago, IL

This study integrates actigraphy, an objective measure of sleep and activity-rest cycles, into several ongoing studies at the University of Illinois, which examine anxiety and mood disorders across the lifespan in order to test the feasibility of actigraphy.

Neural Mechanisms of Attention-Emotion Interactions in Social Anxiety Disorder

UL1RR024986      NIH funded CTSA institutional training program, University of Michigan, Ann Arbor, MI

This study uses fMRI to examine the neural correlates of attentional control over threat-relevant stimuli in individuals with social anxiety disorder.

Other Role: Postdoctoral Fellow Scholar