NIH-NIDA R01 DA040688
The aim of this proposal is to determine the role of delta opioid receptors in trigeminovascular pain (migraine). Specifically, we will characterize the anatomically relevant populations of delta opioid receptor using conditional knockout mice in different mechanistic models of migraine.
The aim of this research is to understand the role of histone deacetylases in headache disorders.
The aim of these studies is to identify the transcriptomic and peptidomic links between opioid use and migraine chronification.
NIH-NIDA R00 DA031243
Delta opioid receptor agonists are currently being developed for the treatment of pain and emotional disorders. However, a sub-population of delta opioid receptor agonists also produce convulsions, a major deterrent to the development of these compounds. The goal of these studies was to determine the mechanism that accounts for this ligand-specific effect.