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The role of delta opioid receptors in trigeminovascular pain

NIH-NIDA R01 DA040688

The aim of this proposal is to determine the role of delta opioid receptors in trigeminovascular pain (migraine). Specifically, we will characterize the anatomically relevant populations of delta opioid receptor using conditional knockout mice in different mechanistic models of migraine.

Epigenetic regulation of migraine

The aim of this research is to understand the role of histone deacetylases in headache disorders.

Overlapping mechanisms between opioid induced hyperalgesia and chronic migraine

The aim of these studies is to identify the transcriptomic and peptidomic links between opioid use and migraine chronification.

In Vivo Implications of Agonist Selective Activation of Delta Opioid Receptor

NIH-NIDA R00 DA031243

Delta opioid receptor agonists are currently being developed for the treatment of pain and emotional disorders. However, a sub-population of delta opioid receptor agonists also produce convulsions, a major deterrent to the development of these compounds. The goal of these studies was to determine the mechanism that accounts for this ligand-specific effect.