The major focus of my lab is to understand how opioid receptors regulate chronic pain and headache disorders. We were the first group to develop a novel preclinical model of chronic migraine, which we used to identify the delta opioid receptor as a novel therapeutic target for this disorder.
The CLEAR Lab, led by Tory Eisenlohr-Moul, Ph.D., seeks to CLarify the Endocrinology of Acute Risk for emotional distress, interpersonal problems, substance abuse, and suicide attempts across the menstrual cycle in at-risk females. We seek to clarify the underlying pathophysiology of DSM-5 premenstrual dysphoric disorder, cyclical worsening of other psychiatric disorders, and perimenopausal mood symptoms. We use both mechanistic experimental trials and intensive observational studies in clinical samples, with the ultimate goal of predicting and preventing severe psychiatric outcomes.
The overarching goal of the Clinical Cognitive Affective Neuroscience (CCAN) lab is to increase our understanding of anxiety, depression, and mechanisms of treatment (e.g., Cognitive Behavioral Therapy) to reduce the suffering associated with these and other debilitating internalizing psychopathologies (e.g., stress-related disorders). Our methods include functional magnetic resonance imaging (fMRI), psychophysiological measures such as electroencephalogram (EEG), behavioral and subjective measures (e.g., neuropsychological, actigraphy, self-report) to advance our understanding of several interrelated themes.
The CAR lab examines cognitive and affective processes involved in the regulation of negative affect, in an effort to identify vulnerability factors for mood disorders.
The goal of Dr. Subhash Pandey’s research program is to better understand the molecular and epigenetic mechanisms of alcohol addiction and comorbid psychiatric disorders such as anxiety. Using various models, we aim to identify the molecular pathways in specific brain circuits that are altered by acute and long-term exposure to alcohol during both adolescence and adulthood and mediate addiction and alcohol-related behavioral phenotypes.
The Families, Affective Neuroscience, and Mood Disorders Lab seeks to identify behavioral-brain risk markers and preventive interventions for child and adolescent depression. By combining multiple units of analysis, (i.e., behavioral, EEG, pupil dilation, fMRI), we explore cognitive-affective processing styles involved in the development of depression in youth and also in the transmission of depression from parents to their offspring. The ultimate goal of this research is to develop reliable, objective tools that can aid in the prevention and diagnosis of youth depression.