Alcohol Research Center

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  2. Alcohol Research Center
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  1. Pandey SC, Bohnsack JP. Alcohol makes its epigenetic marks. Cell Metabolism, 2020 j. cmet.2020.01.008 (preview of a publication in Nature)
  2. Kyzar EJ, Pandey SC (2020) Epigenetic regulation of enhancer RNAs in neuropsychiatric disease and addiction. Epigenomics (In press)
  3. Auta J, Gatta E, Davis JM, Zhang H, Pandey SC, Guidotti A. Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment. Nitric Oxide 2020, Apr 9; S1089-8603(20)30003-3. doi: 10.1016/j.niox.2020.04.003. Online ahead of print.
  4. Gorka SM, Teppen T, Radoman M, Phan KL, Pandey SC. Human plasma BDNF is associated with amygdala-prefrontal cortex functional connectivity and problem drinking behaviors. Int J Neuropsychopharmacol 2020, 23(1):1-11. doi: 10.1093/ijnp/pyz057. [Epub ahead of print].
  5. Hamada K, Lasek AW. Receptor tyrosine kinases as therapeutic targets for alcohol use disorder. Neurotherapeutics. 2020 Jan;17(1):4-16. doi: 10.1007/s13311-019-00795-4.
  6. Vandegrift BJ, Hilderbrand ER, Satta R, Tai R, He D, You C, Chen H, Xu P, Coles C, Brodie MS, Lasek AW (2020) Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice. J Neurosci 1 June, JN-RM-2364-19; DOI:
  1. Gatta E, Grayson DR, Auta J, Saudagar V, Dong E, Chen Y, Krishnan HR, Drnevich J, Pandey SC, Guidotti A. Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). Molecular Psychiatry 2019 Jun 25. [Epub ahead of print] PubMed PMID: 31239533.
  2. Kyzar EJ, Zhang H, Pandey SC. Adolescent alcohol exposure epigenetically suppresses amygdala Arc enhancer RNA expression to confer adult anxiety susceptibility. Biological Psychiatry. 2019 Jun 1;85(11):904-914.
  3. Gorka SM, Kreutzer KA, Petrey K, Radoman M, Phan KL. Behavioral and neural sensitivity to uncertain threat in individuals with alcohol use disorder: Associations with drinking behaviors and motives. Addiction Biology. 2019 Jun 7: e12774. doi: 10.1111/adb.12774. [Epub ahead of print] PMID: 31173426.
  4. Pradhan AA, Tipton AF, Zhang H, Akbari A, Pandey SC. Effects of histone deacetylases inhibitors on ethanol withdrawal-induced hyperalgesia. Int J Neuropsychopharmacology 2019 Jun 8. pii: pyz031. [Epub ahead of print] PMID: 31179497.
  5. Dulman RS, Auta J, Teppen T, Pandey SC. Acute ethanol produces ataxia and induces FMR1 expression via histone modifications in the rat cerebellum. Alcohol: Clinical and Experimental Research. 2019 Jun;43(6):1191-1198.
  6. Chen W-Y, Zhang H, Gatta E, Glover EJ, Pandey SC, Lasek, AW. The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal. Alcohol. 2019 Aug;78:79-87.
  7. Sakharkar AJ, Kyzar EJ, Gavin DP, Zhang H, Chen Y, Krishnan HR, Grayson DR, Pandey SC. Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking. Neuropharmacology. 2019 Jun 20;157:107679. [Epub ahead of print] PMID: 31229451.
  8. Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs. Genes Brain Behav. 2019 Jul;18(6): e12562. PMCID: PMC6612599.
  9. Bohnsack JP, Teppen T, Kyzar EJ, Dzitoyeva S, Pandey SC. The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders. Translational Psychiatry. 2019 Feb 6 ; 9(1) : 34.
  10. Tiffani BDM, Zhang H, Teppen T, Sakharkar AJ, Pandey SC. Essential role of histone methyltransferase G9a in rapid tolerance to the anxiolytic effects of ethanol. Int J Neuropsychopharmacology. 2019 Apr 1;22(4):292-302.
  11. Gorka SM, Lieberman L, Kreutzer KA, Carrillo V, Weinberg A, Shankman SA. Error-related neural activity and alcohol use disorder: Differences from risk to remission. Progress in Neuropsychopharmacology & Biological Psychiatry. 2019 Jun 8;92:271-278.
  12. Vetreno RP, Bohnsack JP, Kusumo H, Liu W, Pandey SC, Crews FT. Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise. Addiction Biology. 2019 Feb 18. doi: 10.1111/adb.12731. [Epub ahead of print]
  13. Dong E, Locci V, Gatta E, Grayson DR, Guidotti A. N-Phthalyl-l-Tryptophan like Clozapine (CLO), induces chromatin remodeling in brains of prenatally stressed mice. Molecular Pharmacology. 2019 Jan;95(1):62-69.
  1. Dong E, Guidotti A, Zhang H, Pandey SC. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Neuropharmacology. 2018 Sep 15; 140:76-85.
  2. Grayson DR, Guidotti A. DNA methylation in animal models of psychosis. Prog Mol Biol Transl Sci. 2018;157:105-132.
  3. You, C, Vandegrift, B, and Brodie, M (2018): Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons. Psychopharmacology. 2018 Jun; 235(6): 1711-1726.
  4. You C, Vandegrift B, Zhang H, Lasek A, Pandey S, Brodie M. Histone deacetylase inhibitor suberanilohydroxamic acid (SAHA) treatment reverses hyposensitivity to γ-aminobutyric acid in the ventral tegmental area during ethanol withdrawal. Alcoholism: Clinical and Experimental Research. 2018 Nov; 42(11):2160-2171.
  5. Satta R, Hilderbrand ER, & Lasek AW. Ovarian hormones contribute to high levels of binge-like drinking by female mice. Alcoholism: Clinical and Experimental Research. 2018 Feb; 42(2):286-294.
  6. Lasek A, Chen H, Chen W. Releasing addiction memories trapped in perineuronal nets. Trends Genet. 2018 Mar;34(3):197-208.
  7. Savarese A, Lasek A. Transcriptional regulators as targets for alcohol pharmacotherapies. Handb Exp Pharmacol. 2018;248:623-624.
  8. Hilderbrand E, Lasek A. Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ. Horm. Behav. 2018 Feb;98:159-164.
  9. Savarese A, Lasek A. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Psychoneuroendocrinology. 2018 Jun;92:13-20.
  10. You C, Savarese A, Vandegrift B, He D, Pandey S, Lasek A, Brodie M. Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and moderate binge-like drinking. Neuropharmacology. 2019 Jan;144:29-36.
  11. Zhang H, Kyzar EJ, Bohnsack JP, Kokare DM, Teppen T, Pandey SC. Adolescent alcohol exposure epigenetically regulates CREB signaling in adult amygdala. Sci Rep. 2018 Jul;8(1):10376.
  12. Auta J, Gatta E, Davis JM, Pandey SC, Guidotti A. Potential role for histone deacetylation in chronic diazepam-induced downregulation of alpha1-GABAA receptor subunit expression. Pharmacol Res Prespect. 2018 Jun 26;6(4):e00416.
  13. Moye LS, Novack ML, Tipton AF, Krishnan H, Pandey SC, Pradhan AA. The development of a mouse model in the mTBI-Induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target. Cephalalgia. 2019 Jan;39(1):77-90.
  14. Kalinin S, Gonzalez-Prieto M, Scheiblich H, Lisi L, Kusamo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL. Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. J Neuroinflammation. 2018 May 14;15(1):141.
  15. Mulholland PJ, Teppen TL, Miller KM, Sexton HG, Pandey SC, Swartzwelder HS. Donepezil reverses dendritic spine morphology and adaptations and Fmr1 epigenetic modifications in hippocampus of adult rats after adolescent alcohol exposure. Alcohol: Clin and Exp Res. 2018 Apr;42(4):706-717.
  16. Kumar A, Malhotra P, Coffing H, Priymvada S, Anbazhagan AN, Krishnan HR, Gill RK, Alrefai WA, Gavin DP, Pandey SC, Dudeja PK, Saksena S. Epigenetic modulation of intestinal NA+/H+ Exchanger-3 expression. Am J Physiol Gastrointest Liver Physiol. 2018 Mar 1;314(3): G309-G318.
  17. Balla A, Dong B, Shilpa BM, Vemuri K, Makriyannis A, Pandey SC, Sershen H, Suckow RF, Vinod KY. Cannabinoid-1 receptor neutral antagonist reduces binge-like alcohol consumption and alcohol induced accumbal dopaminergic signaling. Neuropharmacology. 2018 Mar 15;131:200-208.
  18. Boule LA, Ju C, Agudelo M, Parira T, Cannon A, Davis B, Eby J, Cresci G, Samuleson DR, Shakla P, Alrefai WA, Sureshchandra S, Pandey SC, Schnabi B, Curtis BJ, Wyatt TA, Choudhry MA, Kovacs EJ. Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2018 Feb;66:35-43.
  19. Singh H, Wray N, Schappi JM, Rasenick MM. Disruption of lipid-raft localized Gas/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds. Neuropsychopharmacology. 2018 Jun;43(7) :1481-1491.
  20. Hilderbrand E.R, Lasek A.W. Studying sex differences in animal models of addiction: an emphasis on alcohol-related behaviors. ACS Chem. Neurosci. 2018 Aug 15;9(8):1907-1916.
  1. Zhubi A, Chen Y, Guidotti A, Grayson DR. Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects. Int J Dev Neurosci. 2017 Nov;62:63-72. 
  2. Alessandro G, Erbo D, Grayson DR. Epigenetic basis of clozapine action. J Drug Des Res. 2017;4(6). 
  3. Chen H, HeD, Lasek A.W. Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression. Genes Brain Behav. 2017 Sep;16(7):699-708. 
  4. Vandegrift B, You C, Satta R, Brodie M, Lasek A.W. Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol. PLoS One. 2017 Nov 6;12(11):e0187698. PMCID: PMC5673180.
  5. Kokare DM, Kyzar EJ, Sakharkar AJ, Pandey SC. Adolescent alcohol exposure-induced changes in alpha-melanocyte stimulating hormone and neuropeptide Y pathways via histone acetylation in the brain during adulthood. Int. J Neuropyschopharmacology. 2017 Sep 1;20(9):758-768. 
  6. Auta J, Zhang H, Pandey SC, Guidotti, A. Chronic alcohol exposure differentially alters one-carbon metabolism in rat liver and brain. Alcohol Clin Exp Res. 2017 Jun;41(6): 1105-1111.
  7. Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC. Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood. Addiction Biology. 2017 Sep;22(5):1191-1204.
  8. Pandey SC, Kyzar EJ, Zhang H. Epigenetic basis of the dark side of alcohol addiction. Neuropharmacology. 2017 Aug 1;122:74-84.
  9. Tiffani BDM, Pandey SC. Emerging role of epigenetic mechanisms in alcohol addiction. Alcohol Clin Exp Res. 2017 Apr;41(4):666-680.
  10. Palmisano M, Pandey SC. Epigenetic mechanisms of alcoholism and stress-related disorders. Alcohol. 2017 May;60:7-18.
  11. Gatta E, Auta J, Gavin DP, Bhaumik DK, Grayson DR, Pandey SC, Guidotti A. Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD). Neuropsychopharmacology. 2017 Dec 1;20(12) :1013-1026.
  1. Dutton J.W, Chen H, You C, Brodie M.S, Lasek A. Anaplastic lymphoma kinase (ALK) regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Addiction Biology. 2017 May;22(3):665-678. 
  2. Lasek, A.W. Effects of ethanol on brain extracellular matrix: implications for alcohol use disorder. Alcohol. Clin. Exp. Res. 2016 Oct;40(10) :2030-2042. 
  3. Teppen T, Krishnan H, Zhang H, Sakharkar AJ, Pandey SC. The potential role of amygdaloid microRNA-494 in alcohol-induced anxiolysis. Biological Psychiatry. 2016 Nov 1; 80(9): 711-719.
  4. Sakharkar AJ, Vetreno RP, Zhang H, Kokare DM, Crews FT, Pandey SC. A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. Brain Structure & Function. 2016 Dec;221(9): 4691-4703.
  5. Gavin DP, Kusumo H, Zhang H, Guidotti A, Pandey SC. Role of growth arrest and DNA damage-inducible, beta in alcohol-drinking behaviors. Alcohol Clin Exp Res. 2016 Feb; 40(2):263-272.
  6. Kyzar EJ, Floreani C, Teppen TL, Pandey SC. Adolescent alcohol exposure: Burden of epigenetic reprogramming, synaptic remodeling, and adult Psychopathology. Front Neurosci. 2016 May 31;10:222.
  7. Pandey SC. A critical role of brain-derived neurotrophic factor in alcohol consumption. Biological Psychiatry. 2016 Mar 15;79(6):427-429.
  8. Gavin DP, Kusumo H, Sharma RP, Guizzetti M. Ethanol-induced changes in poly (ADP ribose) polymerase and neuronal developmental gene expression. Neuropharmacology. 2016 Nov;110 (Pt A): 287-296.
  9. Rasenick MM. Depression and adenylyl cyclase: sorting out the signals. Biological Psychiatry. 2016 Dec 1;80(11) :812-814.
  10. Nimitvilai S, You C, Arora D.S, McElvain M.A, Vandegrift B, Brodie M.S., Woodward J.J. Differential effects of toluene and ethanol on dopaminergic neurons of the ventral tegmental area. Frontiers in Neuroscience. 2016 Sep 22;10: 434.
  1. Pandey SC, Sakharkar AJ, Tang L, Zhang H. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. Neurobiology of Disease 82, 607-619 (2015).
  2. Chen H, He D, Lasek AW. Repeated binge drinking increases perineuronal nets in the insular cortex. Alcohol Clin Exp Res39(10): 1930-1938 (2015).