Alcohol Research Center

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  2. Alcohol Research Center
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  1. Gatta E, Camussi D, Auta J, Guidotti A, Pandey SC (2022) Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy. Pharmacology and Therapeutics, 240:108299. doi: 10.1016/j.pharmthera.2022.108299.
  2. Bohnsack JP, Zhang H, Wandling GW, He D, Kyzar EJ, Lasek AW, Pandey SC (2022), Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Sci. Adv. 8 (18), abn2748.
  3. Krishnan, H. R., Zhang, H., Chen, Y., Bohnsack, J. P., Shieh, A. W., Kusumo, H., Drnevich, J., Liu, C., Grayson, D. R., Maienschein-Cline, M., & Pandey, S. C. (2022). Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis. Molecular psychiatry, 27(11), 4624–4632.
  4. Dong E, Zhang H, Chu A, Pandey SC (2022) Acute and protracted prenatal stress produce mood disorder-like and ethanol drinking behaviors in male and female adult offspring. Front Behav Neurosci. 16:862390. doi: 10.3389/fnbeh.2022.862390.
  5. Pandey SC, Crews FT, Tapert SF (2022) Editorial- Adolescent brain and alcohol. Frontiers in Pharmacology, 13:1063446. doi: 10.3389/fphar.2022.1063446. eCollection 2022.
  6. Malovic E, Pandey SC (2022) N6-methyladenosine (m6A) epitranscriptomics in synaptic plasticity and behaviors. Neuropsychopharmacology. Aug 16. doi: 10.1038/s41386-022-01414-1. Online ahead of print.
  7. Kyzar EJ, Bohnsack JP, Pandey SC (2022) Current and future perspectives of non-coding RNAs in brain function and neuropsychiatric disease. Biological Psychiatry 91(2):183-193. doi: 10.1016/j.biopsych.2021.08.013.
  8. Blum K, Brodie MS, Pandey SC, Cadet JL, Gupta A, Elman I, Thanos PK, Gondre-Lewis MC, Baron D, Kazmi S, Bowirrat A, Febo M, Badgaiyan RD, Braverman ER, Dennen CA, Gold MS (2022) Researching mitigation of alcohol binge drinking in polydrug abuse: KCNK13 and RASGRF2 gene(s) risk polymorphisms coupled with genetic addiction risk severity (GARS) guiding precision pro-dopamine regulation. J Pers Med.12(6):1009. doi: 10.3390/jpm12061009.
  9. Chen H, Lu Y, Xiong R, Rosales CI, Coles C, Hamada K, Asad N, Thatcher GRJ, Lasek AW (2022) Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice. Alcohol Clin Exp Res., 46(7):1313-1320. doi: 10.1111/acer.14874. PMCID: PMC9357040.
  10. Hou, S., & Glover, E. J. (2022). Pi USB Cam: A Simple and Affordable DIY Solution That Enables High-Quality, High-Throughput Video Capture for Behavioral Neuroscience Research. eNeuro, 9(5), ENEURO.0224-22.2022.
  11. Caradonna, S. G., Einhorn, N. R., Saudagar, V., Khalil, H., Petty, G. H., Lihagen, A., LeFloch, C., Lee, F. S., Akil, H., Guidotti, A., McEwen, B. S., Gatta, E., & Marrocco, J. (2022). Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene. Translational psychiatry, 12(1), 109.
  12. Manzler, C. A., Radoman, M., Khorrami, K. J., & Gorka, S. M. (2022). Association between startle reactivity to uncertain threats and structural brain volume. Psychophysiology59(10), e14074.
  13. Radoman, M., & Gorka, S. M. (2023). Intolerance of uncertainty and functional connectivity of the anterior insula during anticipation of unpredictable reward. International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 183, 1–8.
  1. Patwell R, Yang H, Pandey SC, Glover EJ. An operant ethanol self-administration paradigm that discriminates between appetitive and consummatory behaviors reveals distinct behavioral phenotypes in commonly used rat strains. Neuropharmacology. 2021 Dec 15;201:108836. Doi:10.1016/j.neuropharm.2021.108836. Epub 2021 Oct 12. PMID: 34648771; PMCID: PMC8578460.
  2. Kyzar EJ, Bohnsack JP, Pandey SC.Current and future perspectives of non-coding RNAs in brain function and neuropsychiatric disease. Biological Psychiatry 2021 Aug 24:S0006-3223(21)01536-5. doi: 10.1016/j.biopsych.2021.08.013. Online ahead of print. PMID: 34742545 
  3. Dulman RS, Auta J, Wandling GM, Patwell R, Zhang H, Pandey SC. Persistence of cerebellar ataxia during chronic ethanol exposure is associated with epigenetic up-regulation of Fmr1 gene expression in rat cerebellum. Alcohol Clin Exp Res. 2021 Oct;45(10):2006-2016. doi: 10.1111/acer.14691. Epub 2021 Aug 28. PMID:34453331; PMCID: PMC8602769.
  4. Dulman RS, Zhang H, Banerjee R, Krishnan HR, Dong B, Hungund BL, Vinod KY, Pandey SC. CB1 receptor neutral antagonist treatment epigenetically increases neuropeptide Y expression and decreases alcohol drinking. Neuropharmacology. 2021 Sep 1;195:108623. doi: 10.1016/j.neuropharm.2021.108623. Epub 2021 May 26. PMID: 34048869; PMCID: PMC8410648.
  5. Chen WY, Chen H, Hamada K, Gatta E, Chen Y, Zhang H, Drnevich J, Krishnan HR, Maienschein-Cline M, Grayson DR, Pandey SC, Lasek AW. Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure. Transl Psychiatry. 2021 May 20;11(1):298. doi: 10.1038/s41398-021-01421-8. PMID: 34016951; PMCID: PMC8170676.
  6. You C, Vandegrift BJ, Brodie MS. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol. Alcohol Clin Exp Res. 2021 Jul;45(7):1348-1358. doi: 10.1111/acer.14630. Epub 2021 Jun 2. PMID: 33960499; PMCID: PMC8295203.
  7. Coles C, Lasek AW. Binge-Like Ethanol Drinking Increases Otx2, Wnt1, and Mdk Gene Expression in the Ventral Tegmental Area of Adult Mice. Neurosci Insights. 2021 Apr 16;16:26331055211009850. doi: 10.1177/26331055211009850. PMID: 33954290; PMCID: PMC8058803.
  8. Dulman RS, Wandling GM, Pandey SC. Epigenetic mechanisms underlying pathobiology of alcohol use disorder. Curr Pathobiol Rep. 2020 Sep;8(3):61-73. doi: 10.1007/s40139-020-00210-0. Epub 2020 Jul 29. PMID: 33747641; PMCID: PMC7978409.
  9. Gatta E, Guidotti A, Saudagar V, Grayson DR, Aspesi D, Pandey SC, Pinna G (2021) Epigenetic regulation of GABAergic neurotransmission and neurosteroid biosynthesis in alcohol use disorder. Int J Neuropsychopharmacol. 24: 130-141.doi: 10.1093/ijnp/pyaa073. PMCID: PMC7883893; PMID: 32968808
  10. Hamada K, Ferguson LB, Mayfield RD, Krishnan HR, Maienschein-Cline M, Lasek AW. Binge-like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex. Genes Brain Behav. 2021 Feb 28:e12729. doi: 10.1111/gbb.12729. Epub ahead of print. PMID: 33641239.
  11. Martins de Carvalho L, Chen WY, Lasek AW. Epigenetic mechanisms underlying stress-induced depression. Int Rev Neurobiol. 2021;156:87-126. doi: 10.1016/bs.irn.2020.08.001. Epub 2020 Sep 26. PMID: 33461666; PMCID: PMC8018603.
  12. Dong E, Pandey SC. Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood. Int Rev Neurobiol. 2021;156:185-215. doi: 10.1016/bs.irn.2020.08.004. Epub 2020 Sep 26. PMID: 33461663; PMCID: PMC7864549.
  13. Gatta E, Saudagar V, Auta J, Grayson DR, Guidotti A. Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics. Int Rev Neurobiol. 2021;156:127-183. doi: 10.1016/bs.irn.2020.08.002. Epub 2020 Sep 30. PMID: 33461662; PMCID: PMC7942223.
  14. Bohnsack JP, Pandey SC. Histone modifications, DNA methylation, and the epigenetic code of alcohol use disorder. Int Rev Neurobiol. 2021;156:1-62. doi: 10.1016/bs.irn.2020.08.005. Epub 2020 Oct 17. PMID: 33461661; PMCID: PMC7990320.
  15. Radoman M, Lieberman L, Jimmy J, Gorka SM. Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing. Soc Cogn Affect Neurosci. 2021 Mar 24;16(4):370-382. doi: 10.1093/scan/nsab006. PMID: 33449089; PMCID: PMC7990065.
  16. Gatta E, Saudagar V, Guidotti A. Alcohol Use Disorder and associated alterations in brain epigenetic marks. “Epigenetics in Psychiatry, Second Edition”. Elsevier, 2021.
  17. Gatta E, Saudagar V, Drnevich J, Forrest MP, Auta J, Clark LV, Sershen H, Smith RC, Grayson DR, Davis JM, Guidotti A. Concordance of Immune-Related Markers in lymphocytes and Prefrontal Cortex in Schizophrenia. Schizophr Bull Open. 2021 Feb 6;2(1):sgab002. doi: 10.1093/schizbullopen/sgab002. eCollection 2021 Jan.PMID: 33585819 
  1. Kyzar EJ, Pandey SC. Epigenetic regulation of enhancer RNAs in neuropsychiatric disease and addiction. Epigenomics. 2020 Jun;12(11):889-892. doi: 10.2217/epi-2020-0135. Epub 2020 Aug 13. PMID: 32787712.
  2. Rodriguez L, You C, Brodie MS, Davies DL. Ethanol antagonizes P2X4 receptors in ventral tegmental area neurons. Neuroreport. 2020 Aug 12;31(12):936-941. doi: 10.1097/WNR.0000000000001504. PMID: 32658126; PMCID: PMC7425777.
  3. Vandegrift BJ, Hilderbrand ER, Satta R, Tai R, He D, You C, Chen H, Xu P, Coles C, Brodie MS, Lasek AW. Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice. J Neurosci. 2020 Jul 1;40(27):5196-5207. doi: 10.1523/JNEUROSCI.2364-19.2020. Epub 2020 Jun 1. PMID: 32482639; PMCID: PMC7329299.
  4. Auta J, Gatta E, Davis JM, Zhang H, Pandey SC, Guidotti A. Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment. Nitric Oxide. 2020 Aug 1;100-101:50-56. doi: 10.1016/j.niox.2020.04.003. Epub 2020 Apr 9. PMID: 32278831; PMCID: PMC7428855.
  5. Pandey SC, Bohnsack JP. Alcohol Makes Its Epigenetic Marks. Cell Metab. 2020 Feb 4;31(2):213-214. doi: 10.1016/j.cmet.2020.01.008. PMID: 32023443; PMCID: PMC7162615.
  6. He D, Lasek AW. Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor. Mol Pharmacol. 2020 Feb;97(2):123-131. doi: 10.1124/mol.119.117473. Epub 2019 Nov 16. PMID: 31734646; PMCID: PMC6964149.
  7. Gorka SM. Interpersonal trauma exposure and startle reactivity to uncertain threat in individuals with alcohol use disorder. Drug Alcohol Depend. 2020 Jan 1;206:107727. doi:10.1016/j.drugalcdep.2019.107727. Epub 2019 Nov 6. PMID:31734035; PMCID: PMC6980731.
  8. Gorka SM, Teppen T, Radoman M, Phan KL, Pandey SC. Human Plasma BDNF Is Associated With Amygdala-Prefrontal Cortex Functional Connectivity and Problem Drinking Behaviors. Int J Neuropsychopharmacol. 2020 Mar 10;23(1):1-11. doi: 10.1093/ijnp/pyz057. PMID: 31722379; PMCID: PMC7064048.
  9. Hamada K, Lasek AW. Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder. Neurotherapeutics. 2020 Jan;17(1):4-16. doi: 10.1007/s13311-019-00795-4. PMID: 31617071; PMCID: PMC7007457.
  10. Chen H, Lasek AW. Perineuronal nets in the insula regulate aversion-resistant alcohol drinking. Addict Biol. 2020 Nov;25(6):e12821. doi:10.1111/adb.12821. Epub 2019 Aug 21. PMID: 31433552; PMCID: PMC7032993.
  11. Gatta E, Grayson DR, Auta J, Saudagar V, Dong E, Chen Y, Krishnan HR, Drnevich J, Pandey SC, Guidotti A. Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). Mol Psychiatry. 2021 Mar;26(3):1029-1041. doi: 10.1038/s41380-019-0449-6. Epub 2019 Jun 25. PMID: 31239533; PMCID: PMC6930366.
  12. Gorka SM, Kreutzer KA, Petrey KM, Radoman M, Phan KL. Behavioral and neural sensitivity to uncertain threat in individuals with alcohol use disorder: Associations with drinking behaviors and motives. Addict Biol. 2020 May;25(3):e12774. doi: 10.1111/adb.12774. Epub 2019 Jun 7. PMID: 31173426; PMCID: PMC6898728.
  13. Vetreno RP, Bohnsack JP, Kusumo H, Liu W, Pandey SC, Crews FT. Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise. Addict Biol. 2020 Mar;25(2):e12731. doi: 10.1111/adb.12731. Epub 2019 Feb 18. PMID: 30779268; PMCID: PMC6698434.
  1. Gatta E, Grayson DR, Auta J, Saudagar V, Dong E, Chen Y, Krishnan HR, Drnevich J, Pandey SC, Guidotti A. Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1). Molecular Psychiatry 2019 Jun 25. [Epub ahead of print] PubMed PMID: 31239533.
  2. Kyzar EJ, Zhang H, Pandey SC. Adolescent alcohol exposure epigenetically suppresses amygdala Arc enhancer RNA expression to confer adult anxiety susceptibility. Biological Psychiatry. 2019 Jun 1;85(11):904-914.
  3. Gorka SM, Kreutzer KA, Petrey K, Radoman M, Phan KL. Behavioral and neural sensitivity to uncertain threat in individuals with alcohol use disorder: Associations with drinking behaviors and motives. Addiction Biology. 2019 Jun 7: e12774. doi: 10.1111/adb.12774. [Epub ahead of print] PMID: 31173426.
  4. Pradhan AA, Tipton AF, Zhang H, Akbari A, Pandey SC. Effects of histone deacetylases inhibitors on ethanol withdrawal-induced hyperalgesia. Int J Neuropsychopharmacology 2019 Jun 8. pii: pyz031. [Epub ahead of print] PMID: 31179497.
  5. Dulman RS, Auta J, Teppen T, Pandey SC. Acute ethanol produces ataxia and induces FMR1 expression via histone modifications in the rat cerebellum. Alcohol: Clinical and Experimental Research. 2019 Jun;43(6):1191-1198.
  6. Chen W-Y, Zhang H, Gatta E, Glover EJ, Pandey SC, Lasek, AW. The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal. Alcohol. 2019 Aug;78:79-87.
  7. Sakharkar AJ, Kyzar EJ, Gavin DP, Zhang H, Chen Y, Krishnan HR, Grayson DR, Pandey SC. Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking. Neuropharmacology. 2019 Jun 20;157:107679. [Epub ahead of print] PMID: 31229451.
  8. Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs. Genes Brain Behav. 2019 Jul;18(6): e12562. PMCID: PMC6612599.
  9. Bohnsack JP, Teppen T, Kyzar EJ, Dzitoyeva S, Pandey SC. The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders. Translational Psychiatry. 2019 Feb 6 ; 9(1) : 34.
  10. Tiffani BDM, Zhang H, Teppen T, Sakharkar AJ, Pandey SC. Essential role of histone methyltransferase G9a in rapid tolerance to the anxiolytic effects of ethanol. Int J Neuropsychopharmacology. 2019 Apr 1;22(4):292-302.
  11. Gorka SM, Lieberman L, Kreutzer KA, Carrillo V, Weinberg A, Shankman SA. Error-related neural activity and alcohol use disorder: Differences from risk to remission. Progress in Neuropsychopharmacology & Biological Psychiatry. 2019 Jun 8;92:271-278.
  12. Vetreno RP, Bohnsack JP, Kusumo H, Liu W, Pandey SC, Crews FT. Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: Restoration with voluntary exercise. Addiction Biology. 2019 Feb 18. doi: 10.1111/adb.12731. [Epub ahead of print]
  13. Dong E, Locci V, Gatta E, Grayson DR, Guidotti A. N-Phthalyl-l-Tryptophan like Clozapine (CLO), induces chromatin remodeling in brains of prenatally stressed mice. Molecular Pharmacology. 2019 Jan;95(1):62-69.
  1. Dong E, Guidotti A, Zhang H, Pandey SC. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Neuropharmacology. 2018 Sep 15; 140:76-85.
  2. Grayson DR, Guidotti A. DNA methylation in animal models of psychosis. Prog Mol Biol Transl Sci. 2018;157:105-132.
  3. You, C, Vandegrift, B, and Brodie, M (2018): Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons. Psychopharmacology. 2018 Jun; 235(6): 1711-1726.
  4. You C, Vandegrift B, Zhang H, Lasek A, Pandey S, Brodie M. Histone deacetylase inhibitor suberanilohydroxamic acid (SAHA) treatment reverses hyposensitivity to γ-aminobutyric acid in the ventral tegmental area during ethanol withdrawal. Alcoholism: Clinical and Experimental Research. 2018 Nov; 42(11):2160-2171.
  5. Satta R, Hilderbrand ER, & Lasek AW. Ovarian hormones contribute to high levels of binge-like drinking by female mice. Alcoholism: Clinical and Experimental Research. 2018 Feb; 42(2):286-294.
  6. Lasek A, Chen H, Chen W. Releasing addiction memories trapped in perineuronal nets. Trends Genet. 2018 Mar;34(3):197-208.
  7. Savarese A, Lasek A. Transcriptional regulators as targets for alcohol pharmacotherapies. Handb Exp Pharmacol. 2018;248:623-624.
  8. Hilderbrand E, Lasek A. Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ. Horm. Behav. 2018 Feb;98:159-164.
  9. Savarese A, Lasek A. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Psychoneuroendocrinology. 2018 Jun;92:13-20.
  10. You C, Savarese A, Vandegrift B, He D, Pandey S, Lasek A, Brodie M. Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and moderate binge-like drinking. Neuropharmacology. 2019 Jan;144:29-36.
  11. Zhang H, Kyzar EJ, Bohnsack JP, Kokare DM, Teppen T, Pandey SC. Adolescent alcohol exposure epigenetically regulates CREB signaling in adult amygdala. Sci Rep. 2018 Jul;8(1):10376.
  12. Auta J, Gatta E, Davis JM, Pandey SC, Guidotti A. Potential role for histone deacetylation in chronic diazepam-induced downregulation of alpha1-GABAA receptor subunit expression. Pharmacol Res Prespect. 2018 Jun 26;6(4):e00416.
  13. Moye LS, Novack ML, Tipton AF, Krishnan H, Pandey SC, Pradhan AA. The development of a mouse model in the mTBI-Induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target. Cephalalgia. 2019 Jan;39(1):77-90.
  14. Kalinin S, Gonzalez-Prieto M, Scheiblich H, Lisi L, Kusamo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL. Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. J Neuroinflammation. 2018 May 14;15(1):141.
  15. Mulholland PJ, Teppen TL, Miller KM, Sexton HG, Pandey SC, Swartzwelder HS. Donepezil reverses dendritic spine morphology and adaptations and Fmr1 epigenetic modifications in hippocampus of adult rats after adolescent alcohol exposure. Alcohol: Clin and Exp Res. 2018 Apr;42(4):706-717.
  16. Kumar A, Malhotra P, Coffing H, Priymvada S, Anbazhagan AN, Krishnan HR, Gill RK, Alrefai WA, Gavin DP, Pandey SC, Dudeja PK, Saksena S. Epigenetic modulation of intestinal NA+/H+ Exchanger-3 expression. Am J Physiol Gastrointest Liver Physiol. 2018 Mar 1;314(3): G309-G318.
  17. Balla A, Dong B, Shilpa BM, Vemuri K, Makriyannis A, Pandey SC, Sershen H, Suckow RF, Vinod KY. Cannabinoid-1 receptor neutral antagonist reduces binge-like alcohol consumption and alcohol induced accumbal dopaminergic signaling. Neuropharmacology. 2018 Mar 15;131:200-208.
  18. Boule LA, Ju C, Agudelo M, Parira T, Cannon A, Davis B, Eby J, Cresci G, Samuleson DR, Shakla P, Alrefai WA, Sureshchandra S, Pandey SC, Schnabi B, Curtis BJ, Wyatt TA, Choudhry MA, Kovacs EJ. Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2018 Feb;66:35-43.
  19. Singh H, Wray N, Schappi JM, Rasenick MM. Disruption of lipid-raft localized Gas/tubulin complexes by antidepressants: a unique feature of HDAC6 inhibitors, SSRI and tricyclic compounds. Neuropsychopharmacology. 2018 Jun;43(7) :1481-1491.
  20. Hilderbrand E.R, Lasek A.W. Studying sex differences in animal models of addiction: an emphasis on alcohol-related behaviors. ACS Chem. Neurosci. 2018 Aug 15;9(8):1907-1916.
  1. Zhubi A, Chen Y, Guidotti A, Grayson DR. Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects. Int J Dev Neurosci. 2017 Nov;62:63-72. 
  2. Alessandro G, Erbo D, Grayson DR. Epigenetic basis of clozapine action. J Drug Des Res. 2017;4(6). 
  3. Chen H, HeD, Lasek A.W. Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression. Genes Brain Behav. 2017 Sep;16(7):699-708. 
  4. Vandegrift B, You C, Satta R, Brodie M, Lasek A.W. Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol. PLoS One. 2017 Nov 6;12(11):e0187698. PMCID: PMC5673180.
  5. Kokare DM, Kyzar EJ, Sakharkar AJ, Pandey SC. Adolescent alcohol exposure-induced changes in alpha-melanocyte stimulating hormone and neuropeptide Y pathways via histone acetylation in the brain during adulthood. Int. J Neuropyschopharmacology. 2017 Sep 1;20(9):758-768. 
  6. Auta J, Zhang H, Pandey SC, Guidotti, A. Chronic alcohol exposure differentially alters one-carbon metabolism in rat liver and brain. Alcohol Clin Exp Res. 2017 Jun;41(6): 1105-1111.
  7. Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC. Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood. Addiction Biology. 2017 Sep;22(5):1191-1204.
  8. Pandey SC, Kyzar EJ, Zhang H. Epigenetic basis of the dark side of alcohol addiction. Neuropharmacology. 2017 Aug 1;122:74-84.
  9. Tiffani BDM, Pandey SC. Emerging role of epigenetic mechanisms in alcohol addiction. Alcohol Clin Exp Res. 2017 Apr;41(4):666-680.
  10. Palmisano M, Pandey SC. Epigenetic mechanisms of alcoholism and stress-related disorders. Alcohol. 2017 May;60:7-18.
  11. Gatta E, Auta J, Gavin DP, Bhaumik DK, Grayson DR, Pandey SC, Guidotti A. Emerging Role of One-Carbon Metabolism and DNA Methylation Enrichment on δ-Containing GABAA Receptor Expression in the Cerebellum of Subjects with Alcohol Use Disorders (AUD). Neuropsychopharmacology. 2017 Dec 1;20(12) :1013-1026.
  1. Dutton J.W, Chen H, You C, Brodie M.S, Lasek A. Anaplastic lymphoma kinase (ALK) regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Addiction Biology. 2017 May;22(3):665-678. 
  2. Lasek, A.W. Effects of ethanol on brain extracellular matrix: implications for alcohol use disorder. Alcohol. Clin. Exp. Res. 2016 Oct;40(10) :2030-2042. 
  3. Teppen T, Krishnan H, Zhang H, Sakharkar AJ, Pandey SC. The potential role of amygdaloid microRNA-494 in alcohol-induced anxiolysis. Biological Psychiatry. 2016 Nov 1; 80(9): 711-719.
  4. Sakharkar AJ, Vetreno RP, Zhang H, Kokare DM, Crews FT, Pandey SC. A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. Brain Structure & Function. 2016 Dec;221(9): 4691-4703.
  5. Gavin DP, Kusumo H, Zhang H, Guidotti A, Pandey SC. Role of growth arrest and DNA damage-inducible, beta in alcohol-drinking behaviors. Alcohol Clin Exp Res. 2016 Feb; 40(2):263-272.
  6. Kyzar EJ, Floreani C, Teppen TL, Pandey SC. Adolescent alcohol exposure: Burden of epigenetic reprogramming, synaptic remodeling, and adult Psychopathology. Front Neurosci. 2016 May 31;10:222.
  7. Pandey SC. A critical role of brain-derived neurotrophic factor in alcohol consumption. Biological Psychiatry. 2016 Mar 15;79(6):427-429.
  8. Gavin DP, Kusumo H, Sharma RP, Guizzetti M. Ethanol-induced changes in poly (ADP ribose) polymerase and neuronal developmental gene expression. Neuropharmacology. 2016 Nov;110 (Pt A): 287-296.
  9. Rasenick MM. Depression and adenylyl cyclase: sorting out the signals. Biological Psychiatry. 2016 Dec 1;80(11) :812-814.
  10. Nimitvilai S, You C, Arora D.S, McElvain M.A, Vandegrift B, Brodie M.S., Woodward J.J. Differential effects of toluene and ethanol on dopaminergic neurons of the ventral tegmental area. Frontiers in Neuroscience. 2016 Sep 22;10: 434.
  1. Pandey SC, Sakharkar AJ, Tang L, Zhang H. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. Neurobiology of Disease 82, 607-619 (2015).
  2. Chen H, He D, Lasek AW. Repeated binge drinking increases perineuronal nets in the insular cortex. Alcohol Clin Exp Res39(10): 1930-1938 (2015).