2. Profile
  3. Scott A. Langenecker

Scott A. Langenecker PhD

Scott A. Langenecker
Designation
  • Professor of Psychiatry
  • University of Utah
Contact Information
  • slangen [at] uic.edu
  • No Location (NONE)

Website

Dr. Langenecker is a clinical neuropsychologist, and neuroimaging specialist who focuses on the translational neuroscience of mood disorders. His goal is to contribute to work defining the neural circuits leading to the development and perseveration of depression and related mood disorders, as well as prediction of treatment response. 

Current work by Dr. Langenecker, funded by two grants from the NIMH, focuses on mood disorders in the remitted state. The first study is designed to predict recurrence of depression using performance and neural circuit markers. The second study is assisting in defining key neural and performance markers of mood disorders and how they may have shared and unique features across many mood disorders.Dr. Langenecker directs an adolescent mood disorders neuropsychology clinic, specializing in adaptive transitions from adolescence to adulthood, treatment optimization, and identification of strengths and weaknesses to assist in care for mood disorders and comorbid conditions. 

  • Multifaceted Investigations of the Neurobiology of Depression Subtypes (MINDS)
  • Anxiety Subtypes, Cognition, Emotion, and Neurophysiology of Depression (ASCEND)

  • Peters, A.T., Van Meter, A., Pruitt, P.J., Briceno, E.M., Ryan, K.A., Hagan, M., Weldon, A.L., Kassel, M.T., Vederman, A., Zubieta, J.K., McInnis, M., Weisenbach, S.L., & Langenecker, S.A. Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in negative mood disorders. Psychoneuroendocrinology, (In Press). 

    Peters, A.T., Burkhouse, K. Feldhaus, C.G., Langenecker, S.A., & Jacobs, R.H.  (2016). Aberrant resting-state functional connectivity in limbic and cognitive control networks relates to depression, rumination, and mindfulness: A pilot study among adolescents with a history of depression. Journal of Affective Disorders, 200, 178-181.

    Crane, N.A., Jenkins, L.M., Dion, C., Meyers, K.K., Weldon, A.L., Gabriel, L.B., Walker, S.J., Hsu, D.T., Noll, D.C., Klumpp, H., Phan, K.L., Zubieta, J-K., & Langenecker, S.A. (in press). Comorbid Anxiety Increases Cognitive Control Activation in Major Depressive Disorder. Depression and Anxiety.

    Kassel, M.T., Rao, J.A., Walker, S.J., Briceno, E.M., Gabriel, L.B., Weldon, A.L., Avery, E.T., Haase, B.D., Pecina, M.P., Considine, C.M., Noll, D.C., Bieliauskas, L.A., Starkman, M.N., Zubieta, J-K., Welsh, R.C., Giordani, B., Weisenbach, S.L., Langenecker, S.A. (2016). Decreased Fronto-Limbic Activation and Disrupted Semantic-Cued List Learning in Major Depressive Disorder. Journal of the International Neuropsychological Society

    Jenkins, L.M., Kassel, M.T., Gabriel, L.B., Gowins, J.R., Hymen, E.A., Verges, A., Calamia, M., Crane, N.A., Jacobs, R.H., Ajilore, O., Welsh, R.C., Drevets, W.C., Phillips, M.L., Zubieta, J-K. & Langenecker, S.A. (in press). Amygdala and dorsomedial hyperactivity to emotional faces in youth with remitted Major Depression. Social Cognitive and Affective Neuroscience.

    Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., & Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine

    DelDonno, SR, Crane, N.A., Weldon, AL, Passarotti, A.M., Pruitt, P.J., Gabriel, LB, Yau, W., Meyers, KK, Hsu, DT, Taylor, S.F., Heitzeg, M.M., Herbener, E., Shankman, S.A., Mickey, BJ, Zubieta, JK, Langenecker, SA. (2015). Affective Personality Predictors of Disrupted Reward Learning and Pursuit in Major Depressive Disorder. Psychiatry Research, 230, 56-64.

    Rao, J.A., Kassel, M.T., Weldon, A.L., Avery, E.T., Briceno, E.M., Mann, M., Cornett, B., Kales, H.C., Zubieta, J-K., Welsh, R.C., Langenecker, S.A., Weisenbach, S.L. 2015. The Double Burden of Age and Major Depressive Disorder on the Cognitive Control Network. Psychology and Aging, 30, 475-485.

    Hsu, D.T., Sanford, B.J., Meyers, K.K., Love, T.M., Hazlett, K.E., Walker, S.J., Mickey, B.J., Koeppe, R.A., Langenecker, S.A., Zubieta, J-K. 2015. It still hurts: altered opioid activity in the brain during social rejection and acceptance in major depressive disorder. Molecular Psychiatry. 20, 193-200.

    Ryan, K.A, Dawson, E.L., Kassel, M.T., Weldon, A.L., Marshall, D.F., Meyers, K.K., Gabriel, L.B., Vederman, A.C., Weisenbach, S.L., McInnis, M.G., Zubieta, J-K, Langenecker, S.A. 2015. Shared dimensions of performance and activation dysfunction in cognitive control in females with mood disorders. Brain. 138, 1424-1434.

    Briceno, E.M., Rapport, L.J., Kassel, M.T., Bieliauskas, L.A., Zubieta, J-K., Weisenbach, S.L., Langenecker, S.A.  2014. Age and gender modulate the neural circuitry supporting facial emotion processing in adults with major depressive disorder, American Journal of Geriatric Psychiatry. 14, 1064-7481.

    Langenecker, S.A., Jacobs, R.H., Passarotti, A.M. 2014. Current Neural and Behavioral Dimensional Constructs across Mood Disorders. Current Behavioral Neuroscience Reports. Current Behavioral Neuroscience Reports. 1, 144-153.

    Briceño, E., Weisenbach, S.L., Rapport, L.J., Hazlett, K.E., Bieliauskas, L.A., Haase, B.D., Ransom, M.T., Pecina, M., Schteingart, D.E., Starkman, M.N., Giordani, B., Welsh, R.C., Noll, D.C., Zubieta, J-K., Langenecker, S.A.2014. Shifted Laterality in Inferior Frontal Activation during Emotion Processing in Women with Major Depressive Disorder, Psychological Medicine, 43 (7) , pp. 1433-1445

    Votruba, K.L., Langenecker, S.A., 2013. Age- and Education-based Normative Data for the Parametric Go/No-go Task. Journal of Clinical and Experimental Neuropsychology, Journal of Clinical and Experimental Neuropsychology, 35 (2) , pp. 132-146.

    Langenecker, SA, Weisenbach, SL, Giordani, B, Briceno, EM, Guidotti-Breting, LM, Schallmo, M-P., Leon, H., Noll, D.C., Zubieta, JK., Schteingart, DE, Starkman, MN.  2012. Chronic Hypercortisolemia and Affective Dysfunction, Neuropharmacology, 62 (1), pp. 217-225. DOI: 10.1016/j.neuropharm.2011.07.006.

    Iverson, GL, Brooks, BL, Langenecker, SA, Young, Allan.  Identifying a Cognitive Impairment Subgroup in Adults with Mood Disorders, Journal of Affective Disorders, 132 (3), pp. 360-36. 2011.  DOI: 10.1016/j.jad.2011.03.001 
    Hsu DT, Langenecker SA, Kennedy SE, Zubieta JK, Heitzeg MM.  FMRI BOLD responses to negative stimuli in the prefrontal cortex are dependent on levels of recent negative life stress in major depressive disorder. Psychiatry Research: Neuroimaging, 123(3), 202-208. 2010.  DOI: 10.1016/j.pscychresns.2009.12.002.

    Langenecker, S.A., Saunders, E.F.H., Kade, A.M., Ransom, M.T., McInnis, M.G.  Intermediate Cognitive Phenotypes in Bipolar Disorder, Journal of Affective Disorders, 122, 285–293. 2010.  DOI: 10.1016/j.jad.2009.08.018.

    Pomerleau, O.F., Pomerleau, C.S., Snedecor, S.M., Finkenauer, R., Mehringer, A.M., Langenecker, S.A., Sirevaag, E.J.  Substance use, trait measures, and subjective response to nicotine in never-smokers stratified on family smoking history and sex, Nicotine and Tobacco Research, 11(9):1055-1066, 2009.

    Langenecker SA, Caveney AF, Giordani B, Young EA, Nielson KA, Rapport LJ, Bieliauskas LA, Mordhorst M, Marcus S, Yodkovik N, Kerber K, Berent S, Zubieta J-K. The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic. Psychiatry Research, 152, 143-154. 2007.

    Langenecker, SA, Kennedy, SE, Guidotti, LM, Briceno, EM, Own, L., Hooven, T, Young, EA, Akil, H, Noll, DC, Zubieta, JK.   Frontal and limbic activation during inhibitory control predicts treatment response in Major Depressive Disorder.  Biological Psychiatry, 62(11), 1272-1280. 2007.

    Langenecker SA, Bieliauskas LA, Rapport LJ, Zubieta JK, Wilde EA, Berent S. Face Emotion Perception and Executive Functioning Deficits in Depression, Journal of Clinical and Experimental Neuropsychology, 27(3):320-33, 2005.

    Langenecker SA, Nielson KA, Rao SM. FMRI of healthy older adults during Stroop Interference. NeuroImage, 21:192-200, 2004. 
    Nielson KA, Langenecker SA, Garavan H.  Differences in the functional neuroanatomy of inhibitory control across the adult lifespan.  Psychology and Aging, 17, 56-71, 2002.

    Langenecker SA, Nielson KA. Frontal recruitment during response inhibition in older adults replicated with fMRI. NeuroImage, 20(2):1384-92, 2003.

    Votruba, K.L., Langenecker, S.A., Age- and Education-based Normative Data for the Parametric Go/No-go Task. Journal of Clinical and Experimental Neuropsychology, Journal of Clinical and Experimental Neuropsychology, In Press.

    Wright, S.L., Rapport L.J., Briceno, E.M., Haase, B.D., Vederman, A.C., Bieliauskas L.A., Welsh R.C., Starkman M.N., McInnis, M.G., Zubieta, J-K., Langenecker, S.A., Reduced Emotion Processing Efficiency in Healthy Males Relative to Females.  Soc Cogn Affect Neurosci. 2012 Nov 29. [Epub ahead of print]

    Briceno, E., Weisenbach, S.L., Rapport, L.J., Hazlett, K.E., Bieliauskas, L.A., Haase, B.D., Ransom, M.T., Pecina, M., Schteingart, D.E., Starkman, M.N., Giordani, B., Welsh, R.C., Noll, D.C., Zubieta, J-K., Langenecker, S.A.Shifted Laterality in Inferior Frontal Activation during Emotion Processing in Women with Major Depressive Disorder, Psychological Medicine, in press.

    Lohoff, F.W., Hodge, R., Narasimhan, S., Nall, A., Ferroro, T.N., Mickey, B.J., Heitzeg, M.M., Langenecker, S.A., Zubieta, J-K., Bogdan, R., Nikolova, Y.S., Drabant, E., Hariri, A.R., Bevilacqua, L., Goldman, D., Doyle, G.A. Functional genetic variants in the vesicular monoamine transporter 1 (VMAT1) modulate emotion processing, Molecular Psychiatry, in press.

    Marshall, D.F., Walker, S., Vederman, A., Ryan, K.A., Weldon, A., Saunders, E., Kamali, M., Adams, K., McInnis, M., & Langenecker, S.A., Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder., Psychiatry Res. 2012 Dec 30;200(2-3):252-7. doi: 10.1016/j.psychres.2012.06.013. Epub 2012 Jul 4.

    Votruba, K.L., Rapport, L.J., Whitman, R.D., Johnson, A., & Langenecker, S.A. Neuropsychological Functioning among Patients with Chronic Aphasia Predicts Improvement in Speech Language Therapy, Topics in Stroke Rehabilitation, in press.

    Ryan, K.A., Vederman, A.C., McFadden, E.M., Weldon, A., Kamali, M., Langenecker, S.A., McInnis, M.G.Differential executive functioning performance by phase of bipolar disorder., Bipolar Disord. 2012 Aug;14(5):527-36. doi: 10.1111/j.1399-5618.2012.01032.x.

    Bertocci, M.A., Bebko, G.M., Mullin, B.C., Langenecker, S.A., Ladouceur, C.D., Almeida, J.R.C., Phillips, M.L., Abnormal anterior cingulate cortical and putamen activity distinguish bipolar from unipolar depression in females, Psychological Medicine, 42, 1417-1428, 2012   DOI: 10.1017/S003329171100242X

    Hsu, D.T., Mickey, B.J., Langenecker, S.A., Heitzeg, M.M., Love, T., Wang, H., Kennedy, S.E., Pecina, M., Shafir, T., Hodgkinson, C.A., Enoch, M-A., Goldman, D., Zubieta, J-K. Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing.  J Neurosci. 2012 Feb 29;32(9):3253-60. doi: 10.1523/JNEUROSCI.5533-11.2012.

    Almeida, J.R.C., Kronhaus, D.M., Sibille, E.L., Langenecker, S.A., Versace, A., LaBarbara, E.J., Klein, C.R., Phillips, M.L. Abnormal left-sided orbitomedial prefrontal cortical-amygdala connectivity during happy and fear face processing: a potential neural mechanism of female MDD.  Front Psychiatry. 2011;2:69. doi: 10.3389/fpsyt.2011.00069. Epub 2011 Dec 8.

    Pecina, M., Mickey, B.J., Love, T., Langenecker, S.A., Shen, P-H., Villafuerte, S., Wright, S.L., Stohler, C.S., Glodman, D., Zubieta, J.K.,DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience.  Cortex. 2012 Feb 14. [Epub ahead of print]

    Kamali, M., Saunders, E.H., Prossin, A.R., Brucksch, C., Harrington, G., Langenecker, S.A., McInnis, M.G.Associations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder.  J Affect Disord. 2012 Feb;136(3):350-8. doi: 10.1016/j.jad.2011.11.027. Epub 2011 Dec 10.

    Langenecker, S.A., Weisenbach, SL, Giordani, B, Briceno, EM, Guidotti-Breting, LM, Schallmo, M-P., Leon, H., Noll, D.C., Zubieta, JK., Schteingart, DE, Starkman, MN.  Impact of chronic hypercortisolemia on affective processing.  Neuropharmacology. 2012 Jan;62(1):217-25. doi: 10.1016/j.neuropharm.2011.07.006. Epub 2011 Jul 23.

    Considine, C.M., Weisenbach, S.L., Walker, S.J., McFadden, E.M., Franti, L.M., Bieliauskas, L.A., Giordani, B., Berent, S., Langenecker, S.A.,Auditory memory decrements, without dissimulation, among patients with major depressive disorder.  Arch Clin Neuropsychol. 2011 Aug;26(5):445-53. doi: 10.1093/arclin/acr041. Epub 2011 May 18.

    Vederman, A.C., Wright, Sl.L., Rapport, L.J., Leon, H.M., Haase, B.D., Franti, L.M., Schallmo, MP, Saunders, E.F.H., Kamali, M.M., Young, E.A., Zubieta, JK, Langenecker, S.A., McInnis, M.G.,Modality-specific alterations in the perception of emotional stimuli in Bipolar Disorder compared to Healthy Controls and Major Depressive Disorder.  Cortex. 2012 Sep;48(8):1027-34. doi: 10.1016/j.cortex.2011.03.017. Epub 2011 May 11.

    Iverson, GL, Brooks, BL, Langenecker, S.A., Young, Allan. Identifying a cognitive impairment subgroup in adults with mood disorders.  J Affect Disord. 2011 Aug;132(3):360-7. doi: 10.1016/j.jad.2011.03.001. Epub 2011 Mar 25.

    Mickey, B.J., Zhou, Z., Heitzeg, M.M., Heinz, E., Hodgkinson, C.A., Hsu, D.T., Langenecker, S.A., Love, T.M., Pecina, M., Shafir, T., Stohler, C.S., Goldman, D., Zubieta, JK. Emotion processing, major depression, and functional genetic variation of neuropeptide Y.  Arch Gen Psychiatry. 2011 Feb;68(2):158-66. doi: 10.1001/archgenpsychiatry.2010.197.

    Drag, L.L., Bieliauskas, L.A., Langenecker, S.A., Greenfield, L.J. Cognitive Functioning, Retirement Status, and Age: Results from the Cognitive Changes and Retirement among Senior Surgeons Study, Journal of the American College of Surgeons, 211:303-307. 2010.

    Hsu, DT, Langenecker, SA, Kennedy, SE, Zubieta, JK, Heitzeg, MM. fMRI BOLD responses to negative stimuli in the prefrontal cortex are dependent on levels of recent negative life stress in major depressive disorder.  Psychiatry Res. 2010 Sep 30;183(3):202-8. doi: 10.1016/j.pscychresns.2009.12.002. Epub 2010 Aug 3.

    Langenecker, S.A., Saunders, E.F.H., Kade, A.M., Ransom, M.T., McInnis, M.G.  Intermediate: cognitive phenotypes in bipolar disorder.  J Affect Disord. 2010 May;122(3):285-93. doi: 10.1016/j.jad.2009.08.018. Epub 2009 Oct 1.

    Langenecker, S.A., Finkenauer, R., Snedecor, S.M., Zubieta, J.K., Young, E.A., Marcus, S., Kerber, K., Pomerleau, C.S. (2008). Increased Incidence of Cigarette Smoking in Women with Psychiatric Illness and Willingness to be Contacted about Smoking Cessation Programs.  Chapter 1.  In Women and Depression, P. Hernandez and S. Alonso, Eds., Nova Publishers, New York, pp. 1-14. 

    Wright, S.L., Langenecker, S.A.(2008). Differential risk for emotion processing difficulties by gender and age in Major Depressive Disorder.  Chapter 3., In Women and Depression P. Hernandez and S. Alonso, Eds, Nova Publishers, New York. (pp. 183-216).

    Lee, H.J, Drag, L.L., Bieliauskas, L.A., Langenecker, S.A., Graver, C., O’Neill, J., Results from the cognitive changes and retirement among senior sureons self-report survey.  J Am Coll Surg. 2009 Nov;209(5):668-671.e2. doi: 10.1016/j.jamcollsurg.2009.08.004. Epub 2009 Sep 19.

    Pomerleau, O.F., Pomerleau, C.S., Snedecor, S.M., Finkenauer, R., Mehringer, A.M., Langenecker, S.A., Sirevaag, E.J.  Substance use, trait measures, and subjective response to nicotine in never-smokers stratified on parental smoking history and sex.  Nicotine Tob Res. 2009 Sep;11(9):1055-66. doi: 10.1093/ntr/ntp099. Epub 2009 Jul 24.

    Mickey, BJ, Ducci, F, Hodgkinson, C, Langenecker, SA, Goldman, D, Zubieta, J-K. Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo.  J Neurosci. 2008 Oct 29;28(44):11354-9. doi: 10.1523/JNEUROSCI.2391-08.2008.

    Bieliauskas, L.A., Langenecker, S.A., Graver, C., Lee, H.J., O’Neill, J., Greenfield, L., Cognitive changes and retirement among senior surgeons (CCRASS): results from the CCRASS Study.  J Am Coll Surg. 2008 Jul;207(1):69-78; discussion 78-9. doi: 10.1016/j.jamcollsurg.2008.01.022. Epub 2008 Apr 24.

    Wright, S. L. Langenecker, S.A., Deldin, P.J., Rapport, L.J., Nielson, K.A., Kade, A.A., Own, L.S., Akil, H., Young, E.A., & Zubieta, J-K. Gender-specific disruptions in emotion processing in younger adults with depression.  Depress Anxiety. 2009;26(2):182-9. doi: 10.1002/da.20502.

    Votruba, K.L., Rapport, L.J., Vangel, S.J., Hanks, R.A., Lequerica, A., Whitman, R.D., & Langenecker, S.A.Impulsivity and traumatic brain injury: the relations among behavioral observation, performance measures, and rating scales.  J Head Trauma Rehabil. 2008 Mar-Apr;23(2):65-73. doi: 10.1097/01.HTR.0000314525.93381.69.

    Zackary Boom-Saad, Z., Langenecker, S.A., Bieliauskas,  L.A., Graver, C.J., O’Neiil, J.S., Caveney, A.F., Greenfield, L.J., Minter, R.M. Surgeons outperform normative controls on neuropsychologic tests, but age-related decay of skills persists.  Am J Surg. 2008 Feb;195(2):205-9.

    Paradee, CV, Rapport, LJ, Lumley, MA, Langenecker, SA, Hanks, RA, & Whitman, D (2007). Circadian Preference and Facial Emotion Recognition among Rehabilitation Inpatients.  Journal of Head Trauma Research, 53, 46-53.

    Langenecker SA, Briceno EM, Hamid NM, Nielson KA. Contributions of functional and volumetric MRI to understanding response control in elders. Brain Research, 1135, 58-68, 2007. PMID: 17210145

    Langenecker, SA, Kennedy, SE, Guidotti, LM, Briceno, EM, Own, L., Hooven, T, Young, EA, Akil, H, Noll, DC, Zubieta, JK.   Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder.  Biol Psychiatry. 2007 Dec 1;62(11):1272-80. Epub 2007 Jun 21.

    Langenecker SA, Zubieta J-K, Young EA, Akil H, Nielson KA.  A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go Test.  J Clin Exp Neuropsychol. 2007 Nov;29(8):842-53. Epub 2006 Mar 12.

    Langenecker SA, Caveney AF, Giordani B, Young EA, Nielson KA, Rapport LJ, Bieliauskas LA, Mordhorst M, Marcus S, Yodkovik N, Kerber K, Berent S, Zubieta J-K. The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic.  Psychiatry Res. 2007 Aug 30;152(2-3):143-54. Epub 2007 Apr 19.

    Hook, JN, Giordani, B, Starkman, MN, Langenecker, SA, Schteingart, DE. Patterns of cognitive change over time and relationship to age following successful treatment of Cushing's disease.  J Int Neuropsychol Soc. 2007 Jan;13(1):21-9.

    Langenecker SA, Bieliauskas LA, Rapport LJ, Zubieta JK, Wilde EA, Berent S. Face emotion perception and executive functioning deficits in depression.  J Clin Exp Neuropsychol. 2005 Apr;27(3):320-33.

    Murphy, K. & Garavan, H. (2004). Artifactual fMRI group and condition differences driven by performance confounds, NeuroImage, 21, 219-228 (dissertation).

    Langenecker SA, Nielson KA, Rao SM. fMRI of healthy older adults during Stroop interference.  Neuroimage. 2004 Jan;21(1):192-200.

    Nielson KA, Langenecker SA, Ross TJ, Garavan H, Stein EA, Rao SM.Comparability of functional MRI response in young and old during inhibition.  Neuroreport. 2004 Jan 19;15(1):129-33.

    Langenecker SA, Nielson KA. Frontal recruitment during response inhibition in older adults replicated with fMRI.  Neuroimage. 2003 Oct;20(2):1384-92.

    Nielson KA, Langenecker SA, Garavan H. Differences in the functional neuroanatomy of inhibitory control across the adult life span.  Psychol Aging. 2002 Mar;17(1):56-71.

    Nielson KA, Garavan H, Langenecker SA, Stein EA, Rao EA. Event-related fMRI of inhibitory control reveals lateralized prefrontal activation differences between healthy young and older adults. Brain and Cognition, 47:169-172, 2001.

Title Description Investigator(s) Category Status
Dimensional RDoC Modeling Across the Range of Negative Mood Dysfunction 4R01MH101487-04 – National Institute of Mental Health Anxiety, Mood, Addiction Research Collaborative On-going

*System-generated list from psychiatry research website.