Olusola Ajilore MD PhD
- Associate Head for Faculty Development
- University of Illinois Center for Depression and Resilience (UI CDR) Professor of Psychiatry
- Director, Mood and Anxiety Disorders Program
- Director, Clinical Research Core/Center for Clinical and Translational Science
- Director, Adult Neuroscience Residency Research Track
- Co-Director, UICOM Medical Scientist Training Program
- Department of Psychiatry
- University of Illinois-Chicago
- oajilore [at] uic.edu
- (312) 413-4562
College of Medicine, Department of Psychiatry
University of Illinois Chicago-
School of Public Health / Psychiatric Institute (SPHPI)
1601 W. Taylor St.
SPHPI MC 912
Chicago IL 60612 - Room #:586 -----------------------------------------------
College of Medicine, Department of Psychiatry
University of Illinois Chicago-
Neuropsychiatric Institute (NPI)
912 S. Wood St.
Department of Psychiatry (MC 913)
Chicago IL 60612 - Room #:625
Dr. Ajilore's research goal is to understand the pathophysiology of major depressive disorder in the context of medical co-morbidities and late life using novel magnetic resonance imaging techniques. His group focuses on using structural and functional brain connectivity to study the brain as a network.
Using these modalities, they have developed innovative ways of discovering brain alterations associated with major depression that may lead to patient-specific targets for intervention and treatment.
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academic
Neuroimaging. Depression and medical co-morbidities. Late-life depression. Mood disorders, Geriatric psychiatry.
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Brain Metabolites in Type 2 Diabetes and Major Depression (funded by NIMH)
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Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., & Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine
Jenkins, L.M., Kassel, M.T., Gabriel, L.B., Gowins, J.R., Hymen, E.A., Verges, A., Calamia, M., Crane, N.A., Jacobs, R.H., Ajilore, O., Welsh, R.C., Drevets, W.C., Phillips, M.L., Zubieta, J-K. & Langenecker, S.A. (in press). Amygdala and dorsomedial hyperactivity to emotional faces in youth with remitted Major Depression. Social Cognitive and Affective Neuroscience
Rittenhouse CD, Ajilore O, Stickgold, R, Hobson, JA. State dependent aspects of attention: Differences in reaction times on an exogenous cuing task. Sleep Research 1993 Vol. 22:96-103
Ajilore O, Stickgold, R, Rittenhouse CD, Hobson, JA. Nightcap: laboratory and home-based evaluation of a portable sleep monitor. Psychophysiology, 1995 Jan, 32(1): 92-8.
Seidman LJ., Kalinowski AG, Kremen WS, Faraone SV, Oscar-Berman M, Ajilore O, Tsuang MT. Experimental and clinical neuropsychological measures of prefrontal dysfunction in schizophrenia. Neuropsychology, 1995 Oct Vol 9(4) 481-490.
Seidman LJ, Oscar-Berman M, Kalinowski AG, Ajilore O, Kremen WS, Faraone SV, Tsuang MT, Neuropsychological Measures of Prefrontal Dysfunction in Schizophrenia. Biological Psychiatry, v. 39(#7) pp. 270-270 Apr 1, 1996 .
Chan, RS, Huey ED, Maecker HL, Cortopassi KM, Howard SA, Iyer AM, McIntosh LJ, Ajilore OA, Brooke SM, Sapolsky RM. Endocrine Modulators of Necrotic Neuron Death. Brain Pathology 1996 Oct; 6(4):481-91.
Ajilore OA and Sapolsky RM. Application of silicon microphysiometry to tissue slices: Detection of metabolic correlates of selective vulnerability. Brain Research 1997 Mar 28; 752(1-2): 99-106.
Ajilore OA and Sapolsky RM. In vivo Characterization of 11beta-Hydroxysteroid Dehydrogenase in Rat Hippocampus Using Glucocorticoid Neuroendangerment as an Endpoint. . Neuroendocrinology 1999 Feb; 69(2):138-144.
Yusim A, Franklin L, Brooke SM, Ajilore OA, Sapolsky RM. Glucocorticoids exacerbate the deleterious effects of gp120 in hippocampal and cortical explants. J Neurochem 2000 Mar;74(3):1000-7.
Yusim A, Ajilore OA, Bliss T, Sapolsky RM. Glucocorticoids exacerbate insult-induced declines in metabolism in selectively vulnerable hippocampal cell fields. Brain Res 2000 Jul 7;870(1-2):109-117.
McLaughlin J, Roozendaal B, Dumas T, Gupta A, Ajilore O, Hsieh J, Ho D, Lawrence M, McGaugh JL, Sapolsky R. Sparing of neuronal function postseizure with gene therapy. .Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12804-9
Rittenhouse CD, Ajilore O, Stickgold, R, Hobson, JA. State dependent aspects of attention: Differences in reaction times on an exogenous cuing task. Sleep Research 1993 Vol. 22:96-103
Ajilore O, Stickgold, R, Rittenhouse CD, Hobson, JA. Nightcap: laboratory and home-based evaluation of a portable sleep monitor. Psychophysiology, 1995 Jan, 32(1): 92-8.
Seidman LJ., Kalinowski AG, Kremen WS, Faraone SV, Oscar-Berman M, Ajilore O, Tsuang MT. Experimental and clinical neuropsychological measures of prefrontal dysfunction in schizophrenia. Neuropsychology, 1995 Oct Vol 9(4) 481-490.
Seidman LJ, Oscar-Berman M, Kalinowski AG, Ajilore O, Kremen WS, Faraone SV, Tsuang MT, Neuropsychological Measures of Prefrontal Dysfunction in Schizophrenia. Biological Psychiatry, v. 39(#7) pp. 270-270 Apr 1, 1996 .
Chan, RS, Huey ED, Maecker HL, Cortopassi KM, Howard SA, Iyer AM, McIntosh LJ, Ajilore OA, Brooke SM, Sapolsky RM. Endocrine Modulators of Necrotic Neuron Death. Brain Pathology 1996 Oct; 6(4):481-91.
Ajilore OA and Sapolsky RM. Application of silicon microphysiometry to tissue slices: Detection of metabolic correlates of selective vulnerability. Brain Research 1997 Mar 28; 752(1-2): 99-106.
Ajilore OA and Sapolsky RM. In vivo Characterization of 11beta-Hydroxysteroid Dehydrogenase in Rat Hippocampus Using Glucocorticoid Neuroendangerment as an Endpoint. . Neuroendocrinology 1999 Feb; 69(2):138-144.
Yusim A, Franklin L, Brooke SM, Ajilore OA, Sapolsky RM. Glucocorticoids exacerbate the deleterious effects of gp120 in hippocampal and cortical explants. J Neurochem 2000 Mar;74(3):1000-7.
Yusim A, Ajilore OA, Bliss T, Sapolsky RM. Glucocorticoids exacerbate insult-induced declines in metabolism in selectively vulnerable hippocampal cell fields. Brain Res 2000 Jul 7;870(1-2):109-117.
McLaughlin J, Roozendaal B, Dumas T, Gupta A, Ajilore O, Hsieh J, Ho D, Lawrence M, McGaugh JL, Sapolsky R.Sparing of neuronal function postseizure with gene therapy. .Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12804-9.
Ajilore OA, Haroon E, Kumaran S, Darwin C, Binesh N, Mintz J, Miller J, Thomas MA, Kumar A. Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neurospychopharmacology. 2007 Jun;32(6):1224-31.
Watari K, Elderkin-Thompson V, Ajilore O, Haroon E, Darwin C, Pham D, Kumar A.. Neuroanatomical correlates of executive functioning in depressed adults with type 2 diabetes. J Clin Exp Neuropsychol. 2007 Aug 3;:1-9.
Kumar A, Ajilore O, Kepe V, Barrio JR, Small G. Mood, cognition and in vivo protein imaging: the emerging nexus in clinical neuroscience. Int J Geriatr Psychiatry. 2007 Nov 29.
Kumar A, Haroon E, Darwin C, Pham D, Ajilore O, Rodriguez G, Mintz J.
Gray matter prefrontal changes in type 2 diabetes detected using MRI. J Magn Reson Imaging. 2008 Jan;27(1):14-9.Watari K, Elderkin-Thompson V, Ajilore O, Haroon E, Darwin C, Pham D, Kumar A. Neuroanatomical correlates of executive functioning in depressed adults with type 2 diabetes. J Clin Exp Neuropsychol. 2008 May;30(4):389-97.
Kumar A, Ajilore O.Neuroimaging and geriatric psychiatry: the story of an interdisciplinary science and mental illness in the elderly. Am J Geriatr Psychiatry. 2009 Jan;17(1):1-3
Haroon E, Watari K, Thomas A, Ajilore O, Mintz J, Elderkin-Thompson V, Darwin C, Kumaran S, Kumar A.Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients. Psychiatry Res. 2009 Jan 30;171(1):10-9.
Kumar A, Gupta R, Thomas A, Ajilore O, Hellemann G.Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression. Arch Gen Psychiatry. 2009 Mar;66(3):324-30
Evidence of Early Retinal Microvascular Changes in Patients With Type 2 Diabetes and Depression. Nguyen TT, Wong TY, Islam FM, Hubbard L, Ajilore O, Haroon E, Darwin C, Esser B, Kumar A. Psychosom Med. 2010 Apr 5
Ajilore OA, Narr KL, Rosenthal J, Pham D, Hamilton L, Watari K, Elderkin-Thompson V, Darwin C, Toga A, Kumar, A. Regional Cortical Gray Matter Thickness Differences Associated with Type 2 Diabetes and Major Depression. Psy Res: Neuroimaging 2010 Sept 8
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the CoNECt lab
The Collaborative Neuroimaging Environment for Connectomics at the University of Illinois Chicago (CoNECt@UIC) is an interdisciplinary team of researchers and clinicians devoted to improving our understanding of brain connectivity using novel techniques from neuroimaging and computational neuroscience. We apply these innovative brain mapping methods to elucidate network-based mechanisms associated with a wide variety of clinical conditions and develop new technology-based treatments to address these mechanisms.
| Title | Description | Investigator(s) | Category | Status |
| BiAffect |
|
the CoNECt lab | On-going | |
| Connectome Visualization |
|
the CoNECt lab | On-going | |
| Connectomics of Mood Disorders |
|
the CoNECt lab | On-going | |
| DiaBetty |
|
the CoNECt lab | On-going | |
| Machine Learning-Deep Learning |
|
the CoNECt lab | On-going | |
| Neuromodulation |
|
the CoNECt lab | On-going | |
| Virtual Reality |
|
the CoNECt lab | On-going |
*System-generated list from psychiatry research website.
| Date | Topic | Category | Status |
| 04/14/2021 | From Connectome to Behaviorome, Network Approaches to Understanding Mood and Cognition | Past Event | |
| 04/30/2020 | The role of theta oscillations in anxiety disorders |
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Past Event |
| 05/18/2018 | Duplicates, Doppelgangers, Systems and Simulacra: A lesion-based network analysis approach to neuropsychiatric syndromes | Past Event | |
| 02/16/2018 | Update on Therapeutics for Treatment of Neurobehavioral Disorders: Traditional and Non-traditional Remedies | Past Event |