2. Profile
  3. Monsheel Sodhi

Monsheel Sodhi PhD

Monsheel Sodhi
Designation
  • Assistant Professor
  • Dept. Molecular Pharmacology and Neuroscience
  • Loyola University Chicago
  • Maywood, Illinois
Website
  • psychiatry

    Pharmacogenomics, molecular basis for psychosis, depression and suicide
  • Sodhi Lab

    Our goal is to understand the molecular basis of psychiatric disorders that predispose individuals to suicide. We investigate gene expression in postmortem brain from individuals with psychiatric illness, including cases of suicide. Our recent work revealed that an epitranscriptomic process known as RNA editing, is elevated in the dorsolateral prefrontal cortex (DLPFC) of depressed suicides. In addition to studies of human brain, we are testing the effects of stress on mouse behavior and neurochemistry. RNA editing regulates brain development and synaptic plasticity, which are impaired in psychiatric disorders, including schizophrenia and depression. Our results suggest that prenatal stress triggers abnormalities in the glutamate system and in RNA editing, which may be precursors for schizophrenia, depression and autism. The objective of this research is to identify new targets for improved therapeutic interventions and to discover biomarkers with which we can predict suicidal behavior, so that preventative strategies can be developed.

    Training Opportunities in the Sodhi Lab: Students, fellows or residents who join Dr. Sodhi’s lab can expect to receive training in molecular genetics, gene expression studies of human tissue, behavioral pharmacology, mammalian cell culture, in addition to gaining expertize in the broader area of the neuropharmacology of schizophrenia, mood disorders and suicide.

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48494246/?sort=date&direction=descending

  • Sodhi MS*, Arranz MJ, Curtis DA, Sham PC, Ball DM, Roberts GW,  Price J,  Collier DA,  Kerwin RW (1995):  Association between clozapine response and allelic variation in the 5-HT2C receptor gene.  NeuroReport 7: 369-75. PMID: 8742444 Times cited=135 *Corresponding author

    Arranz MJ, Collier D, Sodhi MS, Ball DM, Roberts GW, Price J, Sham P, Kerwin R. (1995): Association between clozapine response and allelic variation in the 5-HT2A receptor gene. Lancet, 346: 281-282. PMID:7630250 Times cited=268

    Arranz, M.J., Collier, D.A., Munro, J., Sham, P., Kirov, G., Sodhi, M.S., Roberts, G., Price, J., and Kerwin, R.W. (1996). Analysis of a structural polymorphism in the 5‐HT2A receptor and clinical response to clozapine.Neuroscience Letters 217, 177‐178. PMID:8916101 Times cited=81

    Collier D, Arranz M, Sham P, Battersby S, Gill P, Aitchison KJ, Sodhi MS, et al. (1996): The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. NeuroReport 7:1675-1679. PMID: 8904780 Times cited=149

    Arranz, M.J., Erdmann, J., Kirov, G., Rietschel, M., Sodhi, M.S., Albus, M., Ball, D., Maier, W., Davies, N., Franzek, E., et al. (1997). 5‐HT2A receptor and bipolar affective disorder: association studies in affected patients. Neuroscience Letters 224, 95‐98. PMID:9086465 Times cited=46

    Sodhi, M.S.*, and Murray, R.M. (1997). Future therapies for schizophrenia. Expert Opinion on Therapeutic Patents 7, 151‐165. DOI:10.1517/13543776.7.2.151 Times cited=7* Corresponding author.

    Arranz MJ, Munro J, Birkett J, Bolonna A, Mancama D, Sodhi MS, et al. (2000): Pharmacogenetic prediction of clozapine response. Lancet 355: 1615 - 1616. PMID: 10821369 Times cited=196

    Sodhi, M.S. (2000). The role of the 5-HT2 serotonin receptor subtypes in psychosis: a pharmacogenetic study. Thesis, Kings College, University of London, U.K.[Original research]

    Sodhi MS*, Burnett PJ, Makoff AJ and Harrison PJ.(2001): RNA editing of the 5-HT2C receptor is reduced in schizophrenia. Molecular Psychiatry, 6 (4), 373-9. PMID: 11443520 Times cited=109* Corresponding author.

    Pooley, E, Fairburn C, Cooper, Z, Sodhi MS, Harrison, PJ. (2004) A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Am J Med Genet (Neuropsychiat Genet). 126B: 124-7.  PMID: 15048662 Times cited=50

    Tunbridge, E., P. W. Burnet, Sodhi MS, Harrison PJ (2004). "Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression." Synapse 51(2):112-8.  PMID: 14618678 Times cited=50

    Sodhi, M.S.* and Sanders‐Bush, E. (2004). Serotonin and brain development. International review of neurobiology 59, 111‐174. PMID:15006487 Times cited=122* Corresponding author.

    Sodhi MS*, Airey D, Lambert W, Burnet PWJ, Harrison PJ and Sanders-Bush E. (2005) A rapid new assay to detect RNA editing reveals antipsychotic-induced changes in serotonin-2C transcripts. Mol Pharmacol 68: 711-719. PMID: 15917433 Times cited=28  * Corresponding author.

    Hackler E, Airey D, Shannon C, Sodhi MS, Sanders-Bush E (2006): 5-HT2C receptor RNA editing in the amygdala of inbred strains: implications for anxiety and fear. Neurosci Res 55(1):96-104. PMID: 16580757 Times cited=36 This paper is recommended on the Faculty of 1000 website by Prof. Megan Holmes, Univ. Edinburgh, UK.   https://f1000.com/prime/1014273

    Sodhi MS*, Wood KH, Meador-Woodruff J (2008).  Role of glutamate in schizophrenia: integrating excitatory avenues of research. Expert Review of Neurotherapeutics  8(9): 1389-1406. PMID:18759551 Times cited=23 *Corresponding author

    Roth T, Lubin F, Sodhi MS and Kleinman J E (2009). Epigenetic mechanisms in schizophrenia. Biochim Biophys Acta;1790(9):869-77. PMID: 19559755 Times cited=37

    Simmons, M, Meador-Woodruff, J, Sodhi MS* (2010). “Increased cortical expression of an RNA editing    enzyme occurs in major depressive suicide victims.” Neuroreport 21(15): 993-7. PMID: 20802353. Times cited=4. * Corresponding author.

    Sodhi MS*, Simmons M, McCullumsmith RE, Haroutunian V., Meador‐Woodruff, J. (2011). Glutamatergic gene expression is specifically reduced in thalamocortical projecting relay neurons in schizophrenia. Biological Psychiatry 70:646–654. PMID: 21549355 * Corresponding author. This paper is recommended on the Faculty of 1000 website by Dr. Francine Benes and Dr. Glenn Konopaske, Harvard University, MA. https://f1000.com/prime/12119957

    Bostrom JA, Sodhi MS*. (2013) A Look to the Future: Epigenetics in Psychiatric Disorders and Treatment. In: Lam YWF, Cavallari LH (eds). Pharmacogenomics:  Challenges and Opportunities in Therapeutic Implementation. Elsevier Inc:  Maryland Heights, MO. p.225-246. * Corresponding author.

    Hanson R, Gannon M, Khamo N, Sodhi MS, Orr A, Stubbings J (2013). Improvement in Safety Monitoring of Biologic Response Modifiers After the Implementation of Clinical Care Guidelines by a Specialty Pharmacy Service in an Academic Health System. Journal of Managed Care Pharmacy, 19 (1): 49-67. PMID: 23383700.

    Sodhi, M. Mentor-Mentee Relationships. In ‘Pharmacy Research Success: A How-to Guide for Students, Residents, and New Practitioners’. (Ed. Vellurattil. R) 121-22. (Barnes and Ellis, New York, 2014).

    Bristow, GC, Bostrom, JA, Haroutunian, V, Sodhi, MS (2015). Sex differences in GABAergic gene expression occur in the anterior cingulate cortex in schizophrenia. Schizophrenia Research, 167(1-3):57-63. PMID: 25660468.

    Bonaccorso, S., Sodhi, M.S., Jayathilike, K., and Meltzer, H.Y. Genetic variation of BDNF is associated with antipsychotic induced weight gain syndrome in schizophrenia. Bipolar Disorders, 17(5):528-35. PMID: 25874530.

    Gray A.L., Hyde T.M., Deep-Soboslay A., Kleinman J.E., Sodhi M.S*. (2015). Sex differences in glutamate receptor gene expression in major depression and suicide. Molecular Psychiatry (2015) 20, 1057–1068. PMID: 26169973.

    Qin W, Liu C, Sodhi MS*, Lu H. (2016) Meta-analysis of sex differences in gene expression in schizophrenia. BMC Systems Biology, 10(Suppl 1):9. doi: 10.1186/s12918-015-0250-3. PMID: 26818902. * Corresponding author.

    Powers B, Kleinman JE, Hyde TM, Ajilore O, Leow A, Sodhi MS*. (2019) Differential expression of glutamate transporters and monoaminergic genes in major depression and suicide. BioRxiv Journal. doi: https://doi.org/10.1101/596403