Mark Brodie PhD
- Department of Physiology & Biophysics
- Department of Psychiatry
- Director: Master of Science in Medical Physiology Program
- mbrodie [at] uic.edu
- (312) 996-2373
- (312) 996-1414
Dr. Brodie has studied the effects of acute and chronic alcohol on neurons of the ventral tegmental area (VTA) for many years, and his work has helped elucidate how alcohol acts to increase dopamine neurotransmission in the brain. In conjunction with the CARE, Dr. Brodie is interested in examining epigenetic factors in the VTA that are altered by chronic alcohol exposure and produce sustained changes in the physiology of the VTA during withdrawal. The goal of this work is to understand the neurobiological basis of alcohol effects on the reward and reinforcement systems of the brain.
Electrophysiology of neurons of the ventral tegmental area studied in brain slices, actions of ethanol on the central nervous system; electrophysiological actions of drugs of abuse on brain neurons; epigenetic changes in VTA neurons in response to chronic alcohol exposure.
Vandegrift BJ, You C, Satta R, Brodie MS, Lasek AW. Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol. PLoS One. 2017 Nov 6;12(11):e0187698. doi: 10.1371/journal.pone.0187698. eCollection 2017. PubMed PMID: 29107956.
Nimitvilai S, You C, Arora DS, McElvain MA, Vandegrift BJ, Brodie MS, Woodward JJ. Differential Effects of Toluene and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area. Front Neurosci. 2016 Sep 22;10:434. eCollection 2016. PubMed PMID: 27713687; PubMed Central PMCID: PMC5031606.
Nimitvilai S, Herman M, You C, Arora DS, McElvain MA, Roberto M, Brodie MS. Dopamine D2 receptor desensitization by dopamine or corticotropin releasing factor in ventral tegmental area neurons is associated with increased glutamate release. Neuropharmacology. 2014 Jul;82:28-40. doi: 10.1016/j.neuropharm.2014.03.006. Epub 2014 Mar 19. PubMed PMID: 24657149; PubMed Central PMCID: PMC4038332.
Nimitvilai S, Arora DS, You C, McElvain M, Brodie MS. Phorbol ester reduces ethanol excitation of dopaminergic neurons of the ventral tegmental area: involvement of protein kinase C theta. Front Integr Neurosci. 2013 Dec 25;7:96. doi: 10.3389/fnint.2013.00096. eCollection 2013. PubMed PMID: 24399942; PubMed Central PMCID: PMC3872320.
Nimitvilai S, Arora DS, McElvain MA, Brodie MS. Suppression of Gq Function Using Intra-Pipette Delivery of shRNA during Extracellular Recording in the Ventral Tegmental Area. Front Cell Neurosci. 2013 Feb 12;7:7. doi: 10.3389/fncel.2013.00007. eCollection 2013. PubMed PMID: 23408114; PubMed Central PMCID: PMC3569574.
Nimitvilai S, McElvain MA, Brodie MS. Reversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynamin. J Pharmacol Exp Ther. 2013 Jan;344(1):253-63. doi: 10.1124/jpet.112.199844. Epub 2012 Sep 27. PubMed PMID: 23019137; PubMed Central PMCID: PMC3533415.
Nimitvilai S, Arora DS, McElvain MA, Brodie MS. Reversal of inhibition of putative dopaminergic neurons of the ventral tegmental area: interaction of GABA(B) and D2 receptors. Neuroscience. 2012 Dec 13;226:29-39. doi: 10.1016/j.neuroscience.2012.08.045. Epub 2012 Sep 15. PubMed PMID: 22986166; PubMed Central PMCID: PMC3490029.
Nimitvilai S, Arora DS, McElvain MA, Brodie MS. Ethanol blocks the reversal of prolonged dopamine inhibition of dopaminergic neurons of the ventral tegmental area. Alcohol Clin Exp Res. 2012 Nov;36(11):1913-21. doi: 10.1111/j.1530-0277.2012.01814.x. Epub 2012 May 2. PubMed PMID: 22551160; PubMed Central PMCID: PMC3652026.
Nimitvilai S, McElvain MA, Arora DS, Brodie MS. Reversal of quinpirole inhibition of ventral tegmental area neurons is linked to the phosphatidylinositol system and is induced by agonists linked to G(q). J Neurophysiol. 2012 Jul;108(1):263-74. doi: 10.1152/jn.01137.2011. Epub 2012 Apr 4. PubMed PMID: 22490559; PubMed Central PMCID: PMC3434612.
Nimitvilai S, Arora DS, Brodie MS. Reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase C. Neuropsychopharmacology. 2012 Jan;37(2):543-56. doi: 10.1038/npp.2011.222. Epub 2011 Oct 5. PubMed PMID: 21976045; PubMed Central PMCID: PMC3242316.
|Epigenetic mechanisms of positive affective state of alcoholism||This component will examine novel epigenetic mechanisms (HDAC-induced chromatin remodeling) that may be involved in changes in the putative DA neurons’ response to γ-aminobutyric acid (GABA) after chronic ethanol exposure and its withdrawal.||
||Alcohol Research Center||On-going|
|10/22/2018||Researchers uncover new target of alcohol in the brain||UIC Today|
|11/06/2017||Higher estrogen levels linked to increased alcohol sensitivity in brain's "reward center"||UIC Today|
|02/27/2020||Hyposensitivity of ventral tegmental area neurons to GABA during ethanol withdrawal: Identification of new molecular modulators from RNA-seq||Past Event|
|02/16/2016||The light side of addiction||Past Event|