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  1. Profile
  2. Lech Kiedrowski

Lech Kiedrowski PhD

Designation
  • Research Associate Professor
Contact Information
  • lkiedr [at] uic.edu
  • (312) 413-4559
  • School of Public Health / Psychiatric Institute (SPHPI)
    1601 W. Taylor St.
    SPHPI MC 912
    Chicago IL 60612
  • Room #:Room 564

Dr. Kiedrowski’s long-term objective is to conduct studies aimed at further understanding the mechanisms of neuronal dysfunction or death during neuropsychiatric diseases and stroke, and to identify novel targets for pharmacological intervention to treat these diseases. Currently, Dr. Kiedrowski follows up on the findings described in his recent papers indicating that a drop in intracellular pH triggers intracellular Zn2+ release that likely plays a role in the mechanism of ischemic neuronal death. In this research, the intracellular sources of Zn2+ involved in the acid-induced Zn2+ release are being investigated. Dr. Kiedrowski’s research has been funded by grants from NIH and AHA.

  • Mechanisms of destabilization of ion homeostasis in neurons and astrocytes

  • Extramurally funded projects:

    1. Mechanisms and implications of intracellular Zn2+ release in acidified neurons
    2. Characterization of D3cpv cameleon sensitivity to zinc
    3. Role of NCKX2 in the activation of toxic Zn2+ influx in ischemic neurons
    4. Na-dependent Ca2+ influx and ischemic neuronal death
    5. K+ efflux: Role in Ca2+ homeostasis and excititoxicity