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Leah Rubin PhD MPH

Leah Rubin
Designation
  • Assistant Professor of Neurology
  • Johns Hopkins University
Website Profile Type
  • Collaborator

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Dr. Leah Rubin and Dr. Pauline Maki have collaborated on research related to mental and cognitive health of women across the lifespan since Dr. Rubin began her training at UIC in 2003. Now at Johns Hopkins University, Dr. Rubin continues to work with the Women’s Mental Health Research Program in moving forward her program of research to elucidate the neuroendocrine mechanisms contributing to mental and cognitive health in women. She focuses on the effect of sex steroid hormones, glucocorticoids, vasopressin, and oxytocin on cognition and mental health in healthy women, women living with HIV, and female psychiatric patients. A central long-term goal is to improve the cognitive health of HIV-infected women and women with psychiatric illnesses through an interdisciplinary research career that incorporates epidemiological, mechanistic, and intervention science.

  • psychiatry

    Hormonal contributors to mental and cognitive health, women with HIV, stress, perinatal depression, biostatistics, psychoneuroendocrinology

  • Rubin, L.H., Meyer, V.J., Jamadar, R., Sundermann, E.E., Wu, M., Weber, K.W., Cohen, M.H., Little, D.M., & Maki, P.M. (2015). Prefrontal cortical volume loss is associated with stress-related deficits in verbal learning and memory in HIV-infected women. Neurobiology of Disease. PMID: 26408051

    Rubin, L.H., Pyra, M.Cook, J.A., Weber, K.M., Cohen, M.H., Martin, E., Valcour, V., Milam, J., Anastos, K., Young, M.A., Alden, C., Gustafson, D.R., Maki, P.M. (2015). Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women. Journal of Neurovirology. PMID: 2640443

    Rubin, L.H., Carter, C.S., Drogos, L.L., Pournajafi-Nazarloo, H., Sweeney, J.A., & Maki, P.M. (2015). Effects of sex, menstrual cycle phase, and endogenous hormones on cognition in schizophrenia. Schizophrenia Research, 166(1-3):269-75. PMID: 25990704; PMCID: PMC4512858

    Rubin, L.H. Cook, J.A., Weber, K.M., Cohen, M.H., Martin, E., Valcour, V., Milam, J., Anastos, K., Young, M.A., Alden, C., Gustafson, D.R., & Maki, P.M. (2015). The association of perceived stress and verbal memory is greater in HIV-infected versus HIV-uninfected women. Journal of Neurovirology, 21(4), 422-432. PMID: 25791344

    Valcour, V. Rubin, L.H., Tien, P., Anastos, K., Young, M., Mack, W., Cohen, M., Golub, E.T., Crystal, H., & Maki, P.M. (2015). Human Immunodeficiency Virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: A study of the Women’s Interagency HIV Study (WIHS). Journal of Neurovirology, 21(4):415-21. PMID: 25740539; PMCID: PMC4511712

    Rubin, L.H. and Maki, P.M. (2015). Elucidating postpartum depression through statistics: The value of classification methods. Lancet Psychiatry, 2 (1), 6-8. PMID: 26404435

    Sundermann, E.E., Bishop, J.R., Rubin, L.H., Little, D.M., Meyer, V.J., Martin, E., Weber, K., Cohen, M., & Maki, P.M. (2014). Genetic Predictor of Working Memory and Prefrontal Function in Women with HIV. Journal of Neurovirology, 21(1): 81-91. PMID: 25515329; PMCID: PMC4319991

    Maki, P.M., Rubin, L.H., Valcour, V., Martin, E., Crystal, H.A, Young, M., Weber, K.M., Manly, J., Richardson, J., Alden, C. & Anastos, K. (2014) Cognitive function in women with HIV: Findings from the Women’s Interagency HIV Study. Neurology, 84(3): 231-240. PMID: 25540304; PMCID: PMC4335997

    Rubin, L.H., Sundermann, E.E., Cook, J.A., Martin, E.M., Golub, E.T., Weber, K.M., Cohen, M.H., Crystal, H., Cederbaum, J.A., Anastos, K., Young, M., Greenblatt, R.M., & Maki, P.M. (2014). An investigation of menopausal stage and symptoms on cognition in HIV-infected women. Menopause, 21(9):997-1006. PMID: 24496085; PMCID: PMC4119867

    Rubin, L.H., Haas, G., Keshavan, M., Sweeney, J.A., & Maki, P.M. (2008). Sex differences in cognitive response to antipsychotic treatment. Neuropsychopharmacology, 33(2), 290-297. PMID: 17392734

    Rubin, L.H., Carter, C.S., Drogos, L., Pournajafi-Nazarloo, H.P., Sweeney, J.A., & Maki, P.M. (2010). Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophrenia Research, 124, 13-21. PMID: 20947304; PMCID: PMC2981685

    Rubin, L.H., Carter, C.S., Drogos, L., Jamadar, R., Pournajafi-Nazarloo, H.P., Sweeney, J.A., & Maki, P.M. (2011). Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia. Schizophrenia Research, 130, 266-270. PMID: 21684122; PMCID: PMC3139729

    Rubin, L.H., Carter, C.S., Bishop, J.R., Pournajafi-Nazarloo, H., Harris, M.S., Hill, S.K., Reilly, J.L., & Sweeney, J.A. (2013). Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with untreated first-episode psychosis. Schizophrenia Research, 146(1-3), 138-43. PMID: 23465965; PMCID: PMC3622845
    Rubin, L.H., Carter, C.S., Bishop, J.R., Pournajafi-Nazarloo, H., Drogos, L.L., Hill, S.K., Ruocco, A.C., Keedy, S.K., Reilly, J.L., Keshavan, M.S., Pearlson, G.D., Tamminga, C.A., Gershon, E.S., & Sweeney, J.A. (2014) Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia Bulletin, 40(6): 1374-84. PMID: 24619535

Title Description Investigator(s) Category Status
Effects of Glucocorticoids on Cognitive Functioning in HIV-infected Women NIMH -- R01 MH113512 This R01 grant examines the effects of low-dose hydrocortisone (LDH) on cognition in HIV+ women with the goal to identify and assess an adjunctive therapy for the treatment of cognitive dysfunction in HIV+ women. This study is funded by the National Institute on Mental Health. Women's Mental Health Research Program On-going
Enhancing Perinatal Mental Health: A Feasibility Study of a Collaborative, Translational Research Approach The project goals include: (1) Piloting a randomized controlled trial of a provider training program to improve screening, assessment, and referral procedures for perinatal depression and anxiety disorders during clinical visits; and (2) Establishing an enduring database linking perinatal depression and anxiety diagnoses, medical records, and a biorepository of blood samples from routine perina Women's Mental Health Research Program On-going
Stellate Ganglion Blockade for the Management of Vasomotor Symptoms NIA - R01 AG049924 This multi-year grant supports a randomized, sham-controlled clinical trial of stellate ganglion blockade on vasomotor symptoms in midlife women. Secondary outcomes include cognition, mood, brain imaging outcomes, and autonomic nervous system activity. This study is funded by the National Institute on Aging. Women's Mental Health Research Program On-going
A Feasibility Study of an Intervention to Improve Mother-Infant Synchrony and Emotion Regulation, and the Contributing Role of Oxytocin The primary aim of this pilot study is to demonstrate feasibility of recruitment and retention of women with psychosocial adversities into an intervention study designed to enhance mother-infant synchrony through the use of an auditory, tactile, visual, and vestibular intervention (ATVV). Women's Mental Health Research Program Completed
Cognitive Neuropsychology of HIV and Drug Abuse This is an ongoing program of theory driven research to investigate the unique and additive effects of HIV and substance dependence on selected neurocognitive functions with neuroanatomical and functional significance for neuroAIDS research. Dr. Women's Mental Health Research Program Completed
Cognitive Neuropsychology of HIV and Drug Abuse - Potential Age Effects This goal of this administrative supplement is to investigate effects of HIV serostatus on memory and executive function among a sample of older HIV+ and HIV- cocaine dependent women. This study is funded by the National Institute on Drug Abuse (NIDA - R01 DA012828-14S1). Women's Mental Health Research Program Completed
Effects of Estrogen on Cognition in Schizophrenia The goal of this mentored award was to identify neuroendocrine mechanisms that contribute to variations in cognitive function in schizophrenia. Specifically, Dr. Rubin aimed to characterize how individual variation in estrogen levels affected cognitive abilities that showed a sex difference. Women's Mental Health Research Program Completed
Effects of Stress and Stress Hormones on Cognition in HIV-infected Women The goal of this mentored award is to develop a program of research that addresses the role of stress and stress hormones on cognitive dysfunction among HIV+ women. This study is funded by the National Institute of Mental Health (NIMH - K01 MH098798). Women's Mental Health Research Program Completed
Mental Health, Glucocorticoid Receptor Biology, and Cognition in HIV-Infected Women Using data from the WIHS, this project will examine the potential role of glucorticoid receptor biology as a contributor to psychological risk factors and cognitive function in HIV positive women, as compared to HIV negative women Women's Mental Health Research Program Completed
Oxytocin Alterations in Schizophrenia: Plasma levels and gene methylation in patients and relatives The goal of this project was to investigate endogenous oxytocin and oxytocin receptor epigenetics in patients with schizophrenia, relatives and controls. Women's Mental Health Research Program Completed
Sex Differences in Cognitive Response to a Hydrocortisone Challenge in HIV This pharmacologic challenge explores the impact of hydrocortisone, a glucocorticoid, on cognition and immune response in HIV+ men and women. This study is funded by the National Institute of Mental Health (NIMH - R21 MH099978). Women's Mental Health Research Program Completed
The Role of Endogenous Neurohormones in Modulating Clinical Symptoms, Social/Emotional and Cognitive Functioning in Schizophrenia BIRCWH Scholar: Leah Rubin, PhD Women's Mental Health Research Program Completed