2. Profile
  3. Karl Y. Bosque-Cordero

Karl Y. Bosque-Cordero PhD

Karl Y. Bosque-Cordero
Designation
  • Postdoctoral Research Fellow
  • Department of Psychiatry, UIC
Gender Pronouns
  • he/him
Contact Information
  • karlbos [at] uic.edu
  • School of Public Health / Psychiatric Institute (SPHPI)
    1601 W. Taylor St.
    SPHPI MC 912
    Chicago IL 60612
  • Room #:429
Website

Karl obtained his bachelor's in biology at the University of Puerto Rico at Aguadilla. For his Ph.D. in Biology, he attended the University of Puerto Rico Rio Piedras Campus and completed his dissertation in the laboratory of Dr. Carlos A. Jimenez-Rivera. His thesis explored the contribution of the hyperpolarizing cationic current in cocaine-induced excitability on dopaminergic neurons of the ventral tegmental area using both in vivo single-unit recordings and ex vivo patch-clamp electrophysiology. He joined the Glover Lab in September 2022 and is interested in exploring the basic mechanisms of reward and aversion in alcohol use disorder, focusing on the role that astrocytes may play in altering neurotransmission in the Rostromedial tegmental nucleus and the Lateral Habenula during alcohol withdrawal.

  • Neuronal excitability, reward-related behaviors, and substance use disorder.
  • Astrocytic and Neuronal Adaptations in the Lateral Habenula and Rostromedial Tegmental Nucleus During Withdrawal from Chronic Ethanol
https://www.ncbi.nlm.nih.gov/myncbi/karl.bosque%20cordero.2/bibliography/public/

  • Bosque-Cordero KY, Vazquez-Torres R, Calo-Guadalupe C, Consuegra-Garcia D, Fois GR, Georges F, Jimenez-Rivera CA. Ih blockade reduces cocaine-induced firing patterns of putative dopaminergic neurons of the ventral tegmental area in the anesthetized rat. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jan 10;112:110431. doi: 10.1016/j.pnpbp.2021.110431. Epub 2021 Aug 27. PMID: 34454991; PMCID: PMC8489561.

    Fois GR, Bosque-Cordero KY, Vazquez-Torres R, Miliano C, Nogues X, Jimenez-Rivera CA, Caille S, Georges F. Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons. iScience. 2022 Mar 24;25(4):104154. doi: 10.1016/j.isci.2022.104154. PMID: 35434548; PMCID: PMC9010629.