- Research Assistant Professor
- Department of Psychiatry
- University of Illinois at Chicago
- hbzhang [at] uic.edu
- (312) 355-2648
School of Public Health / Psychiatric Institute (SPHPI)
1601 W. Taylor St.
SPHPI MC 912
Chicago IL 60612
Dr. Huaibo Zhang has been working in the field of epigenetics of the alcoholism using different animal models. He is actively involved in investigating different epigenetic mechanisms (e.g. histone acetylation/deacetylation, DNA methylation/demethylation) and synaptic plasticity in the development of alcohol dependence and alcoholism, which are operative in the impact of adolescent drinking on alcohol abuse at adolescent hood as well as adulthood. He has extensive expertise of methodologies on epigenetic studies and immunohistochemistry as well as behaviours procedures. His goal is to continue working on epigenetic mechanisms involved in molecular mechanisms of alcohol use disorders using different animal models.
Neurobiology of Alcoholism
Epigenetics of Alcoholism
Pandey S, Sakharkar AJ, Tang L, Zhang H. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. Neurobiol Dis. Epub ahead of print.2015
Sakharkar AJ, Tang L, Zhang H, Chen Y, Grayson DR, Pandey SC. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rat. Int J Neuropsychopharmacol. 17:2057-2067. 2014.
Sakharkar A, Zhang H, Tang L, Baxstrom K, Shi G, Moonat S, Pandey SC.Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: A role in anxiety-like and alcohol-drinking behaviors. Int J Neuropsychopharmacol. 17:1207-1220. 2014.
You C ,Zhang H ,Sakharkar A, Teppen T, Pandey SC. Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. Int J Neuropsychopharmacol.17:313-22. 2014.
Moonat S, Sakharkar AJ, Zhang H, Tang L, Pandey SC. Aberrant HDAC2-Mediated Histone Modifications and Synaptic Plasticity in the Amygdala Predisposes to Anxiety and Alcoholism. Biological Psychiatry ,73:763-773,2013
Sakharkar A, Zhang H, Tang L, Shi G, Pandey SC. Histone Deacetylases (HDAC)-Induced Histone Modifications in the Amygdala: A Role in Rapid Tolerance to the Anxiolytic Effects of Ethanol. Alcohol Clin Exp Res. 36:61-71,2012
Moonat S Sakharkar AJ, Zhang H, Pandey SC. The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. Addict Biol.16:238-250, 2011.
Zhang H, Sakharkar A, Shi G, Ugale R, Prakash A, Pandey SC. Neuropeptide Y Signaling in the Central Nucleus of Amygdala Regulates Alcohol-Drinking and Anxiety-Like Behaviors of Alcohol-Preferring Rats. Alcohol Clin Exp Res. 34:451-461, 2010.
Prakash A, Zhang H, Pandey SC. Innate differences in the expression of brain-derived neurotrophic factor in the regions within the extended amygdala between alcohol preferring and nonpreferring rats. Alcohol Clin Exp Res.32:909-920, 2008.
Pandey SC, Ugale R, Zhang H, Tang L, and Prakash A. Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism. The Journal of Neuroscience.28:3729-3737,2008
Pandey SC, Zhang H, Ugale R, Prakash A, Xu T and Misra K. Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. The Journal of Neuroscience.28:2589-2600, 2008.
Pandey SC, Zhang H, Roy A, Xu T and Misra K. Central and Medial Amygdaloid Brain-Derived Neurotrophic Factor Signaling Plays a Critical Role in alcohol drinking and Anxiety-like behaviors. The Journal of Neuroscience. 26:8320-8331, 2006.
Pandey SC, Zhang H, Roy A, Xu T. Deficits in amygdaloid cAMP responsive-element binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J Clinical Investigation.115: 2762-2773, 2005.
Zhou J, Zhang H, Cohen RS, Pandey SC. Effects of estrogen treatment on expression of BDNF and CREB expression and phosphorylation in rat amygdaloid and hippocampal structures. Neuroendocrionogy. 81:294-310, 2005.
Pandey SC, Chartoff EH, Carlezon WA Jr, Zou J, Zhang H, Kreibich AS, Blendy JA, Crews FT. CREB Gene Transcription Factors: Role in Molecular Mechanisms of Alcohol and Drug Addiction. Alcohol Clin Exp Res. 29: 176-184, 2005.
Pandey SC, Roy A, Zhang H, Xu T. Partial deletion of the CREB gene promotes alcohol-drinking behaviors. The Journal of Neuroscience.24: 5022 -5030, 2004.
Zhang H and Pandey SC. Effects of PKA modulation on the expression of neuropeptide Y in rat amygdaloid structures during ethanol withdrawal. Peptides 24:1397-1402, 2003.
Pandey SC, Roy A and Zhang H. The decreased phosphorylation of Cyclic Adenosine Monophosphate(CAMP) response element-binding protein in the central amygdala act as a molecular substrate for anxiety-related to ethanol withdrawal in rats. Alcoholism clinical and Experimental Research. 27: 396-409, 2003.
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