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  1. Profile
  2. Hooriyah Rizavi

Hooriyah Rizavi MSc PhD

Designation
  • Research Specialist- Natural Sciences
  • T32 in the Neuroscience of Mental Health Graduate
Contact Information
  • hrizavi [at] uic.edu
  • (312) 355-5021
  • School of Public Health / Psychiatric Institute (SPHPI)
    1601 W. Taylor St.
    SPHPI MC 912
    Chicago IL 60612
  • Room #:238

Dr. Rizavi received a master’s in Molecular Biotechnology from Wayne State University and earned her Ph.D. in Neuroscience from UIC. She has been involved in the investigation of the neurobiology of depression, bipolar disorder, schizophrenia, and suicide. In that respect she has conducted several studies in the postmortem brain of teenage and adult suicide victims, blood cells from patients with mood disorders, and utilized cell cultures and animal models to test specific hypothesis. She has made important contributions to better understand the possible connection of the stress response, neuroinflammation, and neurotransmitter balance underlying psychopathology. With particular interest in epigenetics, her current research is to study the epigenome and identify specific epigenetic signatures by integrating data from DNA methylation, non-coding RNA, and post-translational modifications that can confer variations in signaling pathways leading to adaptive or mal-adaptive epigenetic changes associated with risk and resilience to mood disorders.

    • Neuroscience
    • Epigenetic mechanisms: DNA methylation, miRNA, lncRNA, histone modifications
    • Transcriptomic analysis
    • Molecular mechanisms
  • Selected Publications

    Pandey GN, Rizavi HS, Bhaumik R, Ren X. Increased protein and mRNA expression of corticotropin-releasing factor (CRF), decreased CRF receptors and CRF binding protein in specific postmortem brain areas of teenage suicide subjects. Psychoneuroendocrinology. 2019 Apr 15;106:233-243.

    Pandey GN, Rizavi HS, Bhaumik R, Ren X. Innate immunity in the postmortem brain of depressed and suicide subjects: Role of Toll-like receptors. Brain Behav Immun. 2019 Jan;75:101-111.

    Pandey GN, Rizavi HS, Zhang H, Bhaumik R, Ren X. Abnormal protein and mRNA expression of inflammatory cytokines in the prefrontal cortex of depressed individuals who died by suicide. J Psychiatry Neurosci. 2018 Nov 1;43(6):376-385.

    Pandey GN, Rizavi HS, Zhang H, Ren X. Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients. Schizophr Res. 2017 May 2.

    Fuchsova B, Alvarez Juliá A, Rizavi HS, Frasch AC, Pandey GN. Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression. Neuroscience. 2016 Oct 1.

    Rizavi HS, Ren X, Zhang H, Bhaumik R, Pandey GN. Abnormal gene expression of proinflammatory cytokines and their membrane-bound receptors in the lymphocytes of depressed patients. Psychiatry Res. 2016 Jun 30;240:314-20.

    Pandey GN, Rizavi HS, Zhang H, Bhaumik R, Ren X. The Expression of the Suicide-Associated Gene SKA2 Is Decreased in the Prefrontal Cortex of Suicide Victims but Not of Nonsuicidal Patients. Int J Neuropsychopharmacol. 2016 Feb 22.

    Dwivedi Y, Roy B, Lugli G, Rizavi H, Zhang H, Smalheiser NR. Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology. Transl Psychiatry. 2015 Nov 17

    Pandey GN, Ren X, Rizavi HS, Zhang H. Proinflammatory cytokines and their membrane-bound receptors are altered in the lymphocytes of schizophrenia patients. Schizophr Res. 2015 May;164(1-3):193-8.

    Pandey GN, Rizavi HS, Tripathi M, Ren X. Region-specific dysregulation of glycogen synthase kinase-3β and β-catenin in the postmortem brains of subjects with bipolar disorder and schizophrenia. Bipolar Disord. 2015 Mar;17(2):160-71.

    Pandey GN, Rizavi HS, Ren X, Bhaumik R, Dwivedi Y. Toll-like receptors in the depressed and suicide brain. J Psychiatr Res. 2014 Jun;53:62-8.

    Smalheiser NR, Lugli G, Rizavi HS, Torvik VI, Turecki G, Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One. 2012;7(3)

    Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, Conley RR, Dwivedi Y. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res. 2012 Jan;46(1):57-63.

    Dwivedi Y., Rizavi H.S., Conley RR., Roberts RC., Tamminga CA., and Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry. 2003 Aug;60(8):804-15.