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  2. Heide Klumpp

Heide Klumpp PhD

Heide Klumpp
Designation
  • Associate Professor
Contact Information
  • hklumpp [at] uic.edu
  • (312) 996-0416
  • Institute for Juvenile Research (IJR)
    1747 W. Roosevelt Rd.
    Chicago IL 60612
  • Room #:246
Website

Dr. Klumpp takes a neuroscience approach to understand internalizing disorders such as anxiety and depression for clinical translation. To this end, she uses electroencephalography and magnetic resonance imaging to delineate brain-based markers of clinical behavior and treatment outcome. She also uses sleep measures (e.g., actigraphy) to understand the intersection of sleep and internalizing disorders.

  • psychiatry

    Brain mechanisms of emotion processing and regulation in anxiety and depression
    Brain markers of clinical behavior and treatment response in anxiety and depression
    Intersection of sleep and emotion processing and regulation in anxiety and depression

    1. Klumpp, H., Chang, F., Bauer, B.W., Burgess, H.J. (2023). Objective and subjective sleep correspond with suicidal ideation and are transdiagnostic features of major depressive disorder and social anxiety disorder. Brain Sciences, 13, 288
    2. Klumpp, H., Bauer, B.W., Glazer, J., Macdonald-Gagnon, G., Feurer, C., Duffecy, J., Medrano, G.R., Craske, M.G., Phan, K.L., Shankman, S.A. (2023). Neural responsiveness to reward and suicidal ideation in social anxiety and major depression before and after psychotherapy. Biological Psychology, 178, 108520
    3. Chang, F., Berenz, E., Ajilore, O., Langenecker, S.A., Burgess, H.J., Phan, K.L., Klumpp, H. (2023). Actigraphic wake after sleep onset and symptom severity correspond with rumination in trauma-exposed individuals. Brain Sciences, 13, 139
    4. McAleer, J., Stewart, L., Shepard, R., Sheena, M., Kabir, S., Swank, I., Stange, J.P., Leow, A., Klumpp, H., Ajilore, O. (2023). Differential effects of transcranial current type on heart rate variability during emotion regulation in internalizing psychopathologies. Journal of Affective Disorders, 327, 7-14
    5. McAleer, J., Stewart, L., Shepard, R., Sheena, M., Stange, J.P., Leow, A., Klumpp, H., Ajilore, O. (2023). Neuromodulatory effects of transcranial electrical stimulation of emotion regulation in internalizing psychopathologies. Clinical Neurophysiology,145, 62-70
    6. Thomas, P.J., Leow, A., Klumpp, H., Phan, K.L., Ajilore, O. (2022). Default mode network hypoalignment of function to structure correlates with depression and rumination. medRxiv
    7. Granros, M., MacNamara, A., Klumpp, H., Phan, K.L., & Burkhouse, K.L. (2022). Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample. Depression and Anxiety, 39, 770-779
    8. Cenkner, D.P., Burgess, H.J., Huizenga, B., Duval, E.R., Kim, H.M., Phan, K.L., Liberzon, I., Klumpp, H., Abelson, J., Horwitz, A., Mooney, A., Raglan, G.B., Zalta, A.K. (2022). Morning light treatment for traumatic stress: The role of amygdala reactivity study protocol. PLoS One Jun 8,17, e0269502
    9. Crane, N.A., Burkhouse, K., Gorka, S., Klumpp, H., Phan, K.L. (2022). Electrocortical measures of win and loss processing are associated with mesocorticolimbic functional connectivity: a combined ERP and rs-fMRI study. Psychophysiology, 59, e14118
    10. Chang, F., Klumpp, H. (2022). Sleep quality and emotion recognition in individuals with and without internalizing psychopathologies. Journal of Behavior Therapy and Experimental Psychiatry, 75, 101719
    11. Feurer, C., Jimmy, J., Bhaumik, R., Duffecy, J., Medrano, G., Ajilore, O., Shankman, S., Langenecker, S., Craske, M., Phan, K.L., Klumpp, H. (2022). Anterior cingulate cortex activation during attentional control as a transdiagnostic marker of psychotherapy response: a randomized clinical trial. Neuropsychopharmacology, 47, 1350-1357
    12. Thomas, P.J., Leow, A., Klumpp, H., Phan, K.L., Ajilore, O. (2022). Network diffusion embedding reveals transdiagnostic subnetwork disruption and potential treatment targets in internalizing psychopathologies. Cerebral Cortex, 32, 1823-1839
    13. Klumpp, H., Jimmy, J., Burkhouse, K.L., Bhaumik, R., Francis, J., Craske, M.G., Phan, K.L., Ajilore, O. (2022). Brain response to emotional faces in anxiety and depression: Neural predictors of cognitive behavioral therapy outcome and predictor-based subgroups following therapy. Psychological Medicine, 52, 2095-2105
    14. Sheena, M.K., Jimmy, J., Burkhouse, K.L., Klumpp, H. (2021). Anterior cingulate cortex activity during attentional control corresponds with rumination in depression and social anxiety. Psychiatry Research: Neuroimaging, 317, 111385
    15. Feurer, C., Francis, J., Ajilore, O., Craske, M.G., Phan, K.L., Klumpp, H. (2021). Emotion regulation and repetitive negative thinking before and after CBT and SSRI treatment of internalizing psychopathologies. Cognitive Therapy and Research, 45, 1064-1076
    16. Kinney, K.L., Burkhouse, K.L., Chang, F., MacNamara, A., Klumpp, H., Phan, K.L. (2021). Neural mechanisms and predictors of SSRI and CBT treatment of anxiety: a randomized trial focused on emotion and cognitive processing. Journal of Anxiety Disorders, 82, 102449
    17. Feurer, C., Jimmy, J., Chang, F., Langenecker, S.A., Phan, K.L., Ajilore, O., Klumpp, H. (2021). Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies. Depression and Anxiety, 38, 488-497
    18. Crane, N.A., Chang, F., Kinney, K.L., Klumpp, H. (2021). Individual differences in striatal and amygdala response to emotional faces are related to symptom severity in social anxiety disorder. NeuroImage: Clinical, 30, 102615 
    19. Crane, N.A., Funkhouser, C.J., Burkhouse, K.L., Klumpp, H., Phan, L.K., Shankman, S.A. (2021). Cannabis users demonstrate enhanced neural reactivity to reward: An event-related potential and time-frequency EEG study. Addictive Behaviors, 113, 106669
    20. Mokatren, L.S., Ansari, R., Cetin, A.E., Leow, A.D., Ajilore, O., Klumpp, H., Vural F.T.Y. EEG (2021).Classification by factoring in sensor spatial configuration. IEEE Access. Digital Object Identifier 10.1109/ACCESS.2021.3054670
    21. Feurer, C., Suor, J., Jimmy, J., Klumpp, H., Monk, C.S., Phan, K.L., Burkhouse, K.L (2021). Differences in cortical thinning across development among individuals with and without anxiety disorders. Depression and Anxiety, 38, 372-381 
    22. Gruhn, M., Phan, K.L., Klumpp, H., Ajilore, O., Gorka, S.M. (2021). Early life adversity as a moderator of symptom change following selective serotonin reuptake inhibitors and cognitive behavioral therapy. Cognitive Therapy and Research, 45, 343-354
    23. Thomas, P.J., Panchamukhi, S., Nathan, J., Francis, J., Langenecker, S., Gorka, S., Leow, A., Klumpp, H., Phan, K.L., Ajilore, O.A. (2020). Graph theoretical measures of the uncinated fasciculus subnetwork as predictors and correlates of treatment response in a transdiagnostic psychiatric cohort. Psychiatry Research: Neuroimaging, 299
    24. Xing, M., Fitzgerald J., Klumpp, H. (2020). Classification of social anxiety disorder with support vector machine analysis using neural correlates of social signals of threat. Frontiers Psychiatry, 11, 144
    25. Marin, M.F, Hammoud, M.Z., Klumpp, H., Simon, N.M., Milad, M.R. (2020). Multimodal categorical and dimensional study of threat conditioning and its extinction in anxious individuals. JAMA Psychiatry, 77, 1-10
    26. Burkhouse, K.L., Jimmy, J., Defelice, N., Klumpp, H., Ajilore, O., Hosseini, B., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2020). Nucleus accumbens volume as a predictor of anxiety symptom improvement following CBT and SSRI treatment in two independent samples. Neuropsychopharmacology, 45, 561-569
    27. Jayakar, R., Tone, E.B., Crosson, B., Turner, J.A., Anderson, P.L., Phan, K.L., Klumpp, H. (2020). Amygdala volume and social anxiety symptom severity: Does segmentation technique matter?  Psychiatry Research: Neuroimaging, 295, 111006
    28. Stange, J.P., Kennedy, A.E., Hajcak, G., Phan, K.L., Klumpp, H. (2020). Brain-behavioral adaptability predicts response to cognitive behavioral therapy for emotional disorders: A person-centered event-related potential study. Neuropsychologia,145:06408
    29. Fitzgerald J., Kinney, K.L., Phan, K.L., Klumpp, H. (2020). Distinct neural engagement during implicit and explicit regulation of negative stimuli. Neuropsychologia, 145:106675
    30. Gorka, S.M., Young, C., Klumpp, H., Kennedy, A.E., Francis, J., Ajilore, O., Langenecker, S., Shankman, S.A., Craske, M.G., Stein, M., Phan, K.L. (2019). Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: A randomized trial. Neuropsychopharmacology, 44, 1639-1648
    31. Kinney, K.L., Burkhouse, K.L., Klumpp, H. (2019). Self-report and neurophysiological indicators of emotion processing and emotion regulation in social anxiety disorder. Biological Psychology, 142, 126-131
    32. Fitzgerald, J.M., Klumpp, H., Langenecker, S., Phan, K.L. (2019). Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression. Depression and Anxiety, 36, 453-464
    33. Klumpp, H., Kinney, K.L., Bhaumik, R., Fitzgerald, J.M. (2019). Principal component analysis and brain-based predictors of emotion regulation in anxiety and depression. Psychological Medicine, 49, 2320-2329
    34. Langenecker, S.A., Klumpp, H., Peters, A.T., Crane, N.A., DelDonno, S.R., Bessette, K.L., Ajilore, O., Leow, A., Shankman, S.A., Walker, S.J., Ransom, M.T., Hsu, D.T., Phan, K.L., Zubieta, J-K., Mickey, B.J., Stange, J.P. (2019). Multidimensional imaging techniques for prediction of treatment response in major depressive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 91, 38-48
    35. Xing, M., Lee, H., Morrissey, Z., Chung, M.K., Phan, K.L., Klumpp, H., Leow, A., Ajilore, O. (2019). Altered dynamic electroencephalography connectome phase-space features of emotion regulation in social anxiety. NeuroImage,186, 338-349
    36. Klumpp, H., Fitzgerald J. (2018). Neuroimaging predictors and mechanisms of treatment response in social anxiety disorder: an overview of the amygdala. Current Psychiatry Reports 20:89
    37. Burkhouse, K.L., Gorka, S.M., Klumpp, H., Kennedy, A.E., Karich, S., Francis, J., Ajilore, O., Craske, M.G., Langenecker, S.A., Shankman, S.A., Hajcak, G., Phan, K.L. (2018). Neural responsiveness to reward as an index of depressive symptom change following cognitive-behavioral therapy and SSRI treatment. Journal of Clinical Psychiatry, 79(4)
    38. Hixson, H., Burkhouse, K.L., Gorka, S.M., Klumpp, H. (2018). A preliminary examination of the relation between neural sensitivity to reward and history of alcohol use disorder among adults with internalizing psychopathologies. Neuroscience Letters, 690, 17-22
    39. Xing, M., GadElkarim, J., Ajilore, O., Wolfson, O., Forbes, A., Phan, K.L., Klumpp, H., Leow, A. (2018). Thought Chart: tracking the thought with manifold learning during emotion regulation. Brain Informatics 5:7
    40. Klumpp, H., Hosseini, B., Phan, K.L. (2018). Self-reported sleep quality modulates amygdala resting-state functional connectivity in anxiety and depression Frontiers in Psychiatry, 9, 220
    41. Klumpp, H., Kinney, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Kumar, A., Phan, K.L. (2018). Trait attentional control modulates neurofunctional response to threat distractors in anxiety and depression. Journal of Psychiatric Research, 102, 87-95
    42. Burkhouse, K.L., Kujawa, A., Hosseini, B., Klumpp, H., Fitzgerald, K. D., Langenecker, S.A., Monk, C.S., Phan, K.L. (2018). Anterior cingulate activation to implicit threat before and after treatment for pediatric anxiety disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, 84, 250-256
    43. Langenecker, S.A., Crane, N.A., Jenkins, L.M., Phan, K.L., Klumpp, H. (2018). Pathways to neuroprediction: Opportunities and challenges to prediction of treatment response in depression. Current Behavioral Neuroscience Reports, 5, 48-60
    44. Gorka, S.M., Burkhouse, K.L., Klumpp, H., Kennedy, A.E., Afshar, K., Francis, J., Ajilore, O., Mariouw S., Craske, M.G., Langenecker, S., Shankman, S.A., Phan, K.L. (2018). Error-related brain activity as a treatment moderator and index of symptom change during cognitive-behavioral therapy or selective serotonin reuptake inhibitors. Neuropsychopharmacology, 43, 1355-1363
    45. Klumpp, H., Bhaumik, R., Kinney, K.L., Fitzgerald, J.M. (2018). Principal component analysis and neural predictors of emotion regulation. Behavioural Brain Research, 338, 128-133
    46. Stange, J.P., Jenkins, L.M., Hamlat, E.J., Bessette, K.L., DelDonno, S., Kling, L.R., Passarotti, A.M., Phan, K.L., Klumpp, H., Ryan, K.A., Langenecker, S.A. (2018). Disrupted engagement of networks supporting hot and cold cognition in remitted major depressive disorder. Journal of Affective Disorders, 227, 183-191
    47. Klumpp, H., Shankman, S.A. (2018). Using event-related potentials and startle to evaluate time course in anxiety and depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 10-18
    48. Bas-Hoogendam, J.M., et al. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical, 16, 678-688
    49. Gorka, S.M., Lieberman, L., Klumpp, H., Kinney, K., Kennedy, A., Ajilore, O., Francis, J., Duffecy, J., Craske, M., Nathan, J., Langenecker, S., Shankman, S.A., Phan, K.L. (2017). Reactivity to unpredictable threat as a treatment target for fear-based anxiety disorders. Psychological Medicine, 47, 2450-2460
    50. Klumpp, H., Roberts, J., Kapella, M.C., Kennedy, A.E., Kumar, A., Phan, K.L. (2017). Subjective and objective sleep quality modulate emotion regulatory brain function in anxiety and depression. Depression and Anxiety, 34, 651-660
    51. MacNamara, A., Klumpp, H., Kennedy, A.E., Langenecker, S.A., Phan, K.L. (2017). Transdiagnostic neural correlates of affective face processing in anxiety and depression. Depression and Anxiety, 34, 621-631
    52. Klumpp, H., Fitzgerald, J.M., Kinney, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Phan, K.L. (2017). Predicting cognitive behavioral therapy response in social anxiety disorder with anterior cingulate cortex and amygdala during emotion regulation. NeuroImage: Clinical, 15, 25-34
    53. Bunford, N., Roberts, J., Kennedy, A.E., Klumpp, H. (2017). Neurofunctional correlates of behavioral inhibition system sensitivity during attentional control are modulated by perceptual load. Biological Psychology, 127, 10-17
    54. Bunford, N., Kinney, K.L., Michael, J., Klumpp, H. (2017). Threat distractor and perceptual load modulate test-retest reliability of anterior cingulate cortex response. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 77, 120-127
    55. Fitzgerald, J.M., Phan, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Klumpp, H. (2017). Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder. Journal of Affective Disorders, 218, 398-406
    56. Burkhouse, K.L., Kujawa, A., Keenan, K., Klumpp, H., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2017). The relation between parent depressive symptoms and neural correlates of attentional control in offspring: A preliminary study. Psychiatry Research, 263, 26-31
    57. Burkhouse, K.L., Kujawa, A., Klumpp, H., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2017). Neural correlates of explicit and implicit emotion processing in relation to treatment response in pediatric anxiety. Journal of Child Psychology and Psychiatry, 58, 546-554
    58. Klumpp, H., Roberts, J., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Gross, J.J., Phan, K.L. (2017). Emotion regulation related neural predictors of cognitive behavioral therapy response in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 75, 106-112
    59. Xing, M., Tadayonnejad, R., MacNamara, A., Ajilore, O., DiGangi, J., Phan, K.L., Leow, A., Klumpp, H. (2017). Resting-state theta band connectivity and graph analysis in generalized social anxiety disorder. NeuroImage: Clinical, 13, 24-32
    60. Tadayonnejad, R., Klumpp, H., Ajilore, O., Leow, A., Phan, K.L. (2016). Aberrant pulvinar effective connectivity in generalized social anxiety disorder. Medicine, 95(45):e5358
    61. Stange, J.P., MacNamara, A., Barnas, O., Kennedy, A.E., Hajcak, G., Phan, K.L., Klumpp, H. (2016). Neural markers of attention to aversive pictures predict response to cognitive behavioral therapy in anxiety and depression. Biological Psychology, 123, 269-277
    62. Kujawa, A., Weinberg, A., Bunford, N., Fitzgerald, K.D., Hanna, G.L., Monk, C.S., Kennedy, A.E., Klumpp, H., Hajcak, G., Phan, K.L. (2016). Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 71, 162-168
    63. Xing, M., Tadayonnejad, R., MacNamara, A., Ajilore, O., Phan, K.L., Klumpp, H., Leow, A (2016). EEG based functional connectivity reflects cognitive load during emotion regulation. IEEE International Symposium on Biomedical Imaging (ISBI), 771-774
    64. Crane, N.A., Jenkins, L.M., Dion, C., Meyers, K.K., Weldon, A.L., Gabriel, L.B., Walker, S.J., Hsu, D.T., Noll, D.C., Klumpp, H., Phan, K.L., Zubieta, J-K., Langenecker, S.A. (2016). Comorbid anxiety increases cognitive control activation in major depressive disorder. Depression and Anxiety, 33, 967-77
    65. Yao, B., Sripada, R.K., Klumpp, H., Abelson, J.L., Muzik, M., Zhao, Z., Rosenblum, K., Briggs, H., Kaston, M., Warren, R. (2016). Penn State Worry Questionnaire – 10: A new tool for measurement-based care. Psychiatry Research, 239, 62-67
    66. Burkhouse, K.L., Kujawa, A., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Phan, K.L., Klumpp, H. (2016). Neural reactivity to reward as a predictor of cognitive behavioral therapy response in anxiety and depression. Depression and Anxiety, 33, 281-8
    67. Kujawa, A., Wu, M., Klumpp, H., Pine, D.S., Swain, J.E., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2016). Altered development of amygdala-frontal connectivity during emotional face processing in anxious youth and young adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1, 345-52
    68. Klumpp, H., Fitzgerald, D.A., Piejko, K., Roberts, J., Kennedy, A.E., Phan, K.L. (2016). Prefrontal control and predictors of cognitive behavioral therapy response in social anxiety disorder. Social Cognitive and Affective Neuroscience, 11, 630-40
    69. Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine, 46, 1055-67
    70. Wu, M., Kujawa, A., Lu, L.H., Fitzgerald, D.A., Klumpp, H., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2016). Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Human Brain Mapping, 37, 1684-95
    71. DiGangi, J.A., Tadayyon, A., Fitzgerald, D.A., Rabinak, C.A., Kennedy, A., Klumpp, H., Rauch, S.A., Phan, K.L. (2016). Reduced default mode network connectivity following combat trauma. Neuroscience Letters, 615, 37-43
    72. Gentili, C., Cristea, I.A., Angstadt, M., Klumpp, H., Tozzi, L., Phan, K.L., Pietrini, P. (2016). Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety. Experimental Biology and Medicine, 241, 225-37
    73. Nelson, B.D., Fitzgerald, D.A., Klumpp, H., Shankman, S.A., Phan, K.L. (2015). Prefrontal engagement by cognitive reappraisal of negative faces. Behavioural Brain Research, 279, 218-25 
    74. Klumpp, H., Keutmann, M.K., Fitzgerald, D.A., Shankman, S.A., Phan, K.L. (2014). Resting state amygdala prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 4, 14
    75. Klumpp, H., Fitzgerald, D.A., Angstadt, M., Post, D., Phan, K.L. (2014). Neural response during attentional control and emotion processing predicts improvement after cognitive behavioral therapy in generalized social anxiety disorder. Psychological Medicine, 44, 3109-21
    76. Wheaton, M.G., Fitzgerald, D.A., Phan, K.L., Klumpp, H. (2014). Perceptual load modulates anterior cingulate cortex response to threat distractors in generalized social anxiety disorder. Biological Psychology, 101, 13-7
    77. Swartz, J.R., Phan, K.L., Angstadt, M., Klumpp, H., Fitzgerald, K.D., Monk, C.S. (2014). Altered activation of the rostral anterior cingulate cortex in the context of emotional face distractors in children and adolescents with anxiety. Depression and Anxiety, 31, 870-9
    78. Klumpp, H., Fitzgerald, D.A., Cook, E., Shankman, S.A., Angstadt, M., Phan, K.L. (2014). Serotonin transporter gene alters insula activity to threat in social anxiety disorder. NeuroReport, 25, 926-931
    79. Klumpp, H., Fitzgerald, D.A., Phan, K.L. (2013). Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 45, 83-91
    80. Klumpp, H., Post, D., Angstadt, M., Fitzgerald, D.A., Phan, K.L. (2013). Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 3, 7
    81. Prater, K.E., Hosanagar, A., Klumpp, H., Angstadt, M., Phan, K.L. (2013). Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depression and Anxiety, 30, 234-241
    82. Klumpp, H., Angstadt, M., Phan, K.L. (2012). Shifting the focus of attention modulates amygdala and anterior cingulate cortex reactivity to emotional faces. Neuroscience Letters, 514, 210-213
    83. Klumpp, H., Angstadt, M., Phan, K.L. (2012). Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological Psychology, 89, 273-276
    84. Klumpp, H., Ho, S., Taylor, S.F., Phan, K.L., Abelson, J.L., Liberzon, I. (2011). Trait anxiety modulates anterior cingulate activation to threat interference. Depression and Anxiety, 28, 194-201
    85. Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L. (2010). Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: An event-related functional MRI study. Psychiatry Research: Neuroimaging, 183, 167-169
    86. Klumpp, H., Amir, N. (2010). Preliminary study of attention training to threat and neutral faces on anxious reactivity to a social stressor in social anxiety. Cognitive Therapy and Research, 34, 263-271
    87. Klumpp,H., Keller, J., Miller, G.A., Casas, B.R., Best, J.L., Deldin, P.J. (2010). Semantic processing of emotional words in depression and schizophrenia. International Journal of Psychophysiology, 75, 211–215 
    88. Klumpp, H., Deldin, P.J. (2010). Review of brain functioning in depression for semantic processing and verbal fluency. International Journal of Psychophysiology,75, 77-85
    89. Amir, N., Beard, C., Taylor, C.T., Klumpp, H., Elias, J., Burns, M., Chen, X. (2009). Attention training in individuals with generalized social phobia: A randomized trial. Journal of Consulting and Clinical Psychology, 77, 961-973
    90. Shah, S.G., Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L. (2009). Amygdala and insula response to emotional images in generalized social anxiety disorder. Journal of Psychiatry and Neuroscience, 34, 296-302
    91. Klumpp, H., Amir, N. (2009). Examination of vigilance and disengagement of threat in social anxiety with a probe detection task. Anxiety, Stress & Coping, 22, 283-296
    92. Klumpp, H., Amir, N., Garfinkel, S. (2009). False memory and obsessive-compulsive symptoms. Depression and Anxiety, 26, 396-402
    93. Amir, N., Klumpp, H., Elias, J., Bedwell, J. S., Yanasak, N., Miller, L.S. (2005). Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. Biological Psychiatry, 57, 975-981
    94. Amir, N., Elias, J., Klumpp, H., Przeworski, A. (2003). Attentional bias to threat in social phobia: facilitated processing or difficulty disengaging attention from threat?  Behaviour Research and Therapy, 41, 1325-1335
    95. Staley, J.K., Van Dyck, C.H., Tan, P.Z., Tikriti, M.A., Ramsby, Q., Klumpp, H., Ng, C., Garg, P. Soufer, R., Baldwin, R.M., Innis, R.B. (2001). Comparison of [18F]Altanserin and [18F]Deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain:  Pharmacological studies. Nuclear Medicine and Biology, 28, 271-279
    96. Van Dyck, C.H., Malison, R.T., Seibyl, J.P., Laruelle, M., Klumpp, H., Zoghbi, S.S., Baldwin, R.M., Innis, R.B. (2000). Age-related decline in central serotonin transporter availability with [123I] ß-CIT SPECT. Neurobiology of Aging, 21, 497-501
Title Description Investigator(s) Category Status
Assessing an electroencephalography (EEG) biomarker of response to transcranial magnetic stimulation for major depression T01 CX002088-03 This study uses EEG to identify biomarkers of response and mechanisms of change as they relate to transcranial magnetic stimulation targeting dorsolateral prefrontal cortex in Veterans with treatment-resistant depression. Dr. Klumpp's Role: Site Co-Investigator at Edward Hines, Jr. VA Hospital, IL Clinical Cognitive Affective Neuroscience Lab On-going
Gaze-Contingent Music Reward Therapy for Social Anxiety R33 MH116089-03      NIH/NIMH The study proposes to modify attentional bias by reinforcing attention to non-threat faces with reward (music) while training attention away from threat faces. The R33 randomized trial will test whether change in attention is associated with clinical improvement.   Clinical Cognitive Affective Neuroscience Lab On-going
Identification of Neural Predictors of Response to Cognitive Behavioral Therapy in Depression and Anxiety Brain & Behavior Research Foundation (formerly NARSAD) The objective of this study is to broaden the clinical impact of an existing NIMH-funded K23 Career Development Award project by including individuals with major depressive disorder.  The project involves longitudinal fMRI and EEG measures of socio-emotional processing and emotion regulation before and after CBT. Clinical Cognitive Affective Neuroscience Lab Completed
Behavioral and Neurophysiological Assessment of Hot and Cold Memory and Executive Function in Treated Breast Cancer Patients University of Illinois Chicago       Center for Clinical and Translational Science Pilot Grant The study examined links between chemotherapy and/or hormone therapy with neurocognitive performance and brain response (i.e., EEG/event-related potentials) in females with breast cancer to understand the impact of treatment on cognitive deficiencies.     Clinical Cognitive Affective Neuroscience Lab Completed
Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety Disorder K23 MH093679-01A2      NIH/NIMH In the context of Cognitive Behavioral Therapy, the project proposes to perform pre- and post-treatment functional MRI of limbic-prefrontal circuitry in patients with social anxiety disorder to examine brain markers of response to therapy and treatment-related brain changes.  Clinical Cognitive Affective Neuroscience Lab Completed
Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety Disorder K23MH093679 – National Institute of Mental Health Anxiety, Mood, Addiction Research Collaborative Completed
Effects of THC on Retention of Memory for Fear Extinction Learning in PTSD R61 MH111935-01    NIH/NIMH Clinical Cognitive Affective Neuroscience Lab Completed
Gaze-Contingent Music Reward Therapy for Social Anxiety R61 MH116089-01     NIH/NIMH The study modifies attentional bias by reinforcing attention to non-threat faces with reward (music) while training attention away from threat faces.  The long-term objective is to test whether such attentional bias modification improves social anxiety symptoms and quality of life.   Clinical Cognitive Affective Neuroscience Lab Completed
Morning Light Treatment for Traumatic Stress: the Role of Amygdala Reactivity R61 MH117157-02   NIH/NIMH Morning bright light treatment is a promising intervention for posttraumatic stress disorder. The study evaluates links between morning light treatment over the course of 4 weeks and mechanisms of symptom improvement.    Clinical Cognitive Affective Neuroscience Lab Completed
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment R01 MH101497-01    NIH/NIMH Clinical Cognitive Affective Neuroscience Lab Completed
Neural Mechanisms of Attention-Emotion Interactions in Social Anxiety Disorder UL1RR024986      NIH funded CTSA institutional training program, University of Michigan, Ann Arbor, MI This study uses fMRI to examine the neural correlates of attentional control over threat-relevant stimuli in individuals with social anxiety disorder. Other Role: Postdoctoral Fellow Scholar Clinical Cognitive Affective Neuroscience Lab Completed
Passive, Mobile Assessment of Sleep, Circadian Timing, and Keyboard Dynamics to Prospectively Predict Depression Severity, Cognition, Emotion Processing, and Emotion Regulation R21 MH121852-01 This study combines actigraphy with the smartphone app ‘BiAffect’ to understand digital behaviors, sleep, and circadian patterns on cognitive function and emotion processing in individuals with major depressive disorder or insomnia.    Clinical Cognitive Affective Neuroscience Lab Completed
Sleep Disturbance in Mood Disorders Across the Lifespan Campus Research Board   Pilot Grant   OVCR Research Development Services, University of Illinois Chicago, Chicago, IL This study integrates actigraphy, an objective measure of sleep and activity-rest cycles, into several ongoing studies at the University of Illinois, which examine anxiety and mood disorders across the lifespan in order to test the feasibility of actigraphy. Clinical Cognitive Affective Neuroscience Lab Completed
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy R01 MH112705-01  NIH/NIMH The study examined mechanisms of change that underlie CBT, and identify predictors of CBT response, in patients with major depressive disorder or social anxiety disorder. Clinical Cognitive Affective Neuroscience Lab Completed
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response 1R01MH112705-01A1 – National Institute of Mental Health Anxiety, Mood, Addiction Research Collaborative Completed