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  2. Heide Klumpp

Heide Klumpp PhD

Heide Klumpp
Designation
  • Assistant Professor
Contact Information
  • (312) 996-0416
  • hklumpp@uic.edu
  • Institute for Juvenile Research (IJR)
    1747 W. Roosevelt Rd.
    Chicago IL 60612
  • Room #:246

Dr. Klumpp's main research interest is using a cognitive-affective neuroscience approach to understand anxiety and depression for clinical translation. She uses neuroimaging to delineate brain markers of response to psychotherapy to increase therapeutic success with available treatment and develop more individually-tailored, novel interventions. In addition, she translates discoveries from basic neuroscience to enhance therapies for anxiety disorders and depression.

  • psychiatry
    • Brain mechanisms of emotion processing and regulation in anxiety and depression
    • Brain markers of treatment response in anxiety and depression
    • Information processing disturbances in internalizing disorders
  • Brain Mechanisms of Cognitive Behavioral Therapy for Anxiety Disorders and Depression

  • Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment

  • Sleep Disturbance in Mood Disorders Across the Lifespan

  • Gorka, S.M., Burkhouse, K.L., Klumpp, H., Kennedy, A.E., Afshar, K., Francis, J., Ajilore, O., Mariouw S., Craske, M.G., Langenecker, S., Shankman, S.A., Phan, K.L. (in press). Error-related brain activity as a treatment moderator and index of symptom change during cognitive-behavioral therapy or selective serotonin reuptake inhibitors. Neuropsychopharmacology

    Stange, J.P., Kennedy, A.E., Hajcak, G., Phan, K.L., Klumpp, H. (in press). Brain-behavioral adaptability predicts response to cognitive behavioral therapy for emotional disorders: A person-centered event-related potential study. Neuropsychologia

    Klumpp, H., Bhaumik, R., Kinney, K.L., Fitzgerald, J.M. (2018). Principal component analysis and neural predictors of emotion regulation. Behavioural Brain Research, 338, 128-133

    Stange, J.P., Jenkins, L.M., Hamlat, E.J., Bessette, K.L., DelDonno, S., Kling, L.R., Passarotti, A.M., Phan, K.L., Klumpp, H., Ryan, K.A., & Langenecker, S.A. (2018). Disrupted engagement of networks supporting hot and cold cognition in remitted major depressive disorder. Journal of Affective Disorders, 227, 183-191

    Klumpp, H., Shankman, S.A. (2018). Using event-related potentials and startle to evaluate time course in anxiety and depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 10-18

    Bas-Hoogendam, J.M., et al. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical, 16, 678-688

    Gorka, S.M., Lieberman, L., Klumpp, H., Kinney, K., Kennedy, A., Ajilore, O., Francis, J., Duffecy, J., Craske, M., Nathan, J., Langenecker, S., Shankman, S.A., & Phan, K.L. (2017). Reactivity to unpredictable threat as a treatment target for fear-based anxiety disorders. Psychological Medicine, 47, 2450-2460

    Klumpp, H., Roberts, J., Kapella, M.C., Kennedy, A.E., Kumar, A., Phan, K.L. (2017). Subjective and objective sleep quality modulate emotion regulatory brain function in anxiety and depression. Depression and Anxiety, 34, 651-660

    MacNamara, A., Klumpp, H., Kennedy, A.E., Langenecker, S.A., Phan, K.L. (2017). Transdiagnostic neural correlates of affective face processing in anxiety and depression. Depression and Anxiety, 34, 621-631

    Klumpp, H., Fitzgerald, J.M., Kinney, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Phan, K.L. (2017). Predicting cognitive behavioral therapy response in social anxiety disorder with anterior cingulate cortex and amygdala during emotion regulation. NeuroImage: Clinical, 15, 25-34

    Bunford, N., Roberts, J., Kennedy, A.E., Klumpp, H. (2017). Neurofunctional correlates of behavioral inhibition system sensitivity during attentional control are modulated by perceptual load. Biological Psychology, 127, 10-17

    Bunford, N., Kinney, K.L., Michael, J., Klumpp, H. (2017). Threat distractor and perceptual load modulate test-retest reliability of anterior cingulate cortex response. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 77, 120-127

    Fitzgerald, J.M, Phan, K.L., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Klumpp, H. (2017). Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder. Journal of Affective Disorders, 218, 398-406

    Burkhouse, K.L., Kujawa, A., Keenan, K., Klumpp, H., Fitzgerald, K.D., Monk, C.S., & Phan, K.L. (2017). The relation between parent depressive symptoms and neural correlates of attentional control in offspring: A preliminary study. Psychiatry Research, 263, 26-31

    Burkhouse, K.L., Kujawa, A., Klumpp, H., Fitzgerald, K.D., Monk, C.S., & Phan, K.L. (2017). Neural correlates of explicit and implicit emotion processing in relation to treatment response in pediatric anxiety. Journal of Child Psychology and Psychiatry, 58, 546-554

    Klumpp, H., Roberts, J., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Gross, J.J., Phan, K.L. (2017). Emotion regulation related neural predictors of cognitive behavioral therapy response in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 75, 106-112

    Xing, M., Tadayonnejad, R., MacNamara, A., Ajilore, O., DiGangi, J., Phan, K.L., Leow, A., Klumpp, H., (2016). Resting-state theta band connectivity and graph analysis in generalized social anxiety disorder. NeuroImage: Clinical, 13, 24-32.

    Tadayonnejad, R., Klumpp, H., Ajilore, O., Leow, A., Phan, K.L. (2016). Aberrant pulvinar effective connectivity in generalized social anxiety disorder. Medicine, 95(45):e5358

    Stange, J.P., MacNamara, A., Barnas, O., Kennedy, A.E., Hajcak, G., Phan, K.L., Klumpp, H. (2016). Neural markers of attention to aversive pictures predict response to cognitive behavioral therapy in anxiety and depression. Biological Psychology, 123, 269-277.

    Kujawa, A., Weinberg, A., Bunford, N., Fitzgerald, K.D., Hanna, G.L., Monk, C.S., Kennedy, A.E., Klumpp, H., Hajcak, G., Phan, K.L. (2016). Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 71, 162-8

    Xing, M., Tadayonnejad, R., MacNamara, A., Ajilore, O., Phan, K.L., Klumpp, H., Leow, A (2016). EEG based functional connectivity reflects cognitive load during emotion regulation. IEEE International Symposium on Biomedical Imaging (ISBI), 771-774

    Crane, N.A., Jenkins, L.M., Dion, C., Meyers, K.K., Weldon, A.L., Gabriel, L.B., Walker, S.J., Hsu, D.T., Noll, D.C., Klumpp, H., Phan, K.L., Zubieta, J-K., & Langenecker, S.A. (2016). Comorbid anxiety increases cognitive control activation in major depressive disorder. Depression and Anxiety, 33, 967-77

    Yao, B., Sripada, R.K., Klumpp, H., Abelson, J.L., Muzik, M., Zhao, Z., Rosenblum, K., Briggs, H., Kaston, M., Warren, R. (2016). Penn State Worry Questionnaire – 10: A new tool for measurement-based care. Psychiatry Research, 239, 62-7

    Burkhouse, K.L., Kujawa, A., Kennedy, A.E., Shankman, S.A., Langenecker, S.A., Phan, K.L., Klumpp, H. (2016). Neural reactivity to reward as a predictor of cognitive behavioral therapy response in anxiety and depression. Depression and Anxiety, 33, 281-8

    Kujawa, A., Wu, M., Klumpp, H., Pine, D.S., Swain, J.E., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2016). Altered development of amygdala-frontal connectivity during emotional face processing in anxious youth and young adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1, 345-52

    Klumpp, H., Fitzgerald, D.A., Piejko, K., Roberts, J., Kennedy, A.E., Phan, K.L. (2016). Prefrontal control and predictors of cognitive behavioral therapy response in social anxiety disorder. Social Cognitive and Affective Neuroscience, 11, 630-40  

    Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., & Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine, 46, 1055-67

    Wu, M., Kujawa, A., Lu, L.H., Fitzgerald, D.A., Klumpp, H., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (2016). Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Human Brain Mapping, 37, 1684-95

    DiGangi, J.A., Tadayyon, A., Fitzgerald, D.A., Rabinak, C.A., Kennedy, A., Klumpp, H., Rauch, S.A., Phan, K.L. (2016). Reduced default mode network connectivity following combat trauma. Neuroscience Letters, 615, 37-43

    Gentili, C., Cristea, I.A., Angstadt, M., Klumpp, H., Tozzi, L., Phan, K.L., Pietrini, P. (2016). Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety. Experimental Biology and Medicine, 241, 225-37

    Nelson, B.D., Fitzgerald, D.A., Klumpp, H., Shankman, S.A., & Phan, K.L. (2015). Prefrontal engagement by cognitive reappraisal of negative faces. Behavioural Brain Research, 279, 218-25

    Klumpp, H., Keutmann, M.K., Fitzgerald, D.A., Shankman, S.A., Phan, K.L. (2014). Resting state amygdala prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 4, 14  

    Fitzgerald, D.A., Angstadt, M., Post, D., Phan, K.L. (2014). Neural response during attentional control and emotion processing predicts improvement after cognitive behavioral therapy in generalized social anxiety disorder. Psychological Medicine, 44, 3109-21

    Wheaton, M.G., Fitzgerald, D.A., Phan, K.L., Klumpp, H. (2014). Perceptual load modulates anterior cingulate cortex response to threat distractors in generalized social anxiety disorder. Biological Psychology, 101, 13-7

    Swartz, J.R., Phan, K.L., Angstadt, M., Klumpp, H., Fitzgerald, K.D., Monk, C.S. (2014). Altered activation of the rostral anterior cingulate cortex in the context of emotional face distractors in children and adolescents with anxiety. Depression and Anxiety, 31, 870-9

    Klumpp, H., Fitzgerald, D.A., Cook, E., Shankman, S.A., Angstadt, M., Phan, K.L. (2014). Serotonin transporter gene alters insula activity to threat in social anxiety disorder. NeuroReport, 25, 926-931

    Klumpp, H., Fitzgerald, D.A., Phan, K.L. (2013). Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 45, 83-91

    Klumpp, H., Post, D., Angstadt, M., Fitzgerald, D.A., Phan, K.L. (2013). Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 3, 7

    Prater, K.E., Hosanagar, A., Klumpp, H., Angstadt, M., Phan, K.L. (2013). Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depression and Anxiety, 30, 234-241

    Klumpp, H., Angstadt, M., Phan, K.L. (2012). Shifting the focus of attention modulates amygdala and anterior cingulate cortex reactivity to emotional faces. Neuroscience Letters, 514, 210-213  

    Klumpp, H., Angstadt, M., Phan, K.L. (2012). Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological Psychology, 89, 273-276  

    Klumpp, H., Ho, S., Taylor, S.F., Phan, K.L., Abelson, J.L., Liberzon, I. (2011). Trait anxiety modulates anterior cingulate activation to threat interference. Depression and Anxiety, 28, 194-201

    Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L. (2010). Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: An event-related functional MRI study. Psychiatry Research: Neuroimaging, 183, 167-169

    Klumpp, H., Amir, N. (2010). Preliminary study of attention training to threat and neutral faces on anxious reactivity to a social stressor in social anxiety. Cognitive Therapy and Research, 34, 263-271

    Keller, J., Miller, G.A., Casas, B.R., Best, J.L., Deldin, P.J. (2010). Semantic processing of for emotional words in depression and schizophrenia. International Journal of Psychophysiology, 75, 211–215   

    Klumpp, H., Deldin, P.J. (2010). Review of brain functioning in depression for semantic processing and verbal fluency. International Journal of Psychophysiology, 75, 77-85 

    Amir, N., Beard, C., Taylor, C.T., Klumpp, H., Elias, J., Burns, M., Chen, X. (2009). Attention training in individuals with generalized social phobia: A randomized trial. Journal of Consulting and Clinical Psychology, 77, 961-973

    Shah, S.G., Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L. (2009). Amygdala and insula response to emotional images in generalized social anxiety disorder. Journal of Psychiatry and Neuroscience, 34, 296-302

    Klumpp, H., Amir, N. (2009). Examination of vigilance and disengagement of threat in social anxiety with a probe detection task. Anxiety, Stress & Coping, 22, 283-296

    Klumpp, H., Amir, N., Garfinkel, S. (2009). False memory and obsessive compulsive symptoms. Depression and Anxiety, 26, 396-402

    Amir, N., Klumpp, H., Elias, J., Bedwell, J. S., Yanasak, N., Miller, L.S. (2005). Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. Biological Psychiatry, 57, 975-981

    Amir, N., Elias, J., Klumpp, H., Przeworski, A. (2003). Attentional bias to threat in social phobia: facilitated processing or difficulty disengaging attention from threat?Behaviour Research and Therapy, 41, 1325-1335

    Staley, J.K., Van Dyck, C.H., Tan, P.Z., Tikriti, M.A., Ramsby, Q., Klumpp, H., Ng, C., Garg, P. Soufer, R., Baldwin, R.M., Innis, R.B. (2001). Comparison of [18F]Altanserin and [18F]Deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain:Pharmacological studies. Nuclear Medicine and Biology, 28, 271-279

    Van Dyck, C.H., Malison, R.T., Seibyl, J.P., Laruelle, M., Klumpp, H., Zoghbi, S.S., Baldwin, R.M., Innis, R.B. (2000). Age-related decline in central serotonin transporter availability with [123I] ß-CIT SPECT. Neurobiology of Aging, 21, 497-501

Title Description Investigator(s) Category Status
Effects of THC on Retention of Memory for Fear Extinction Learning in PTSD NIMH R61MH111935 Clinical Cognitive Affective Neuroscience Lab On-going
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment 4R01MH101497-04 – National Institute of Mental Health MADRP - Phan Lab On-going
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy NIMH R01MH112705 Clinical Cognitive Affective Neuroscience Lab On-going
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response 1R01MH112705-01A1 – National Institute of Mental Health Anxiety, Mood, Addiction Research Collaborative On-going
Identification of Neural Predictors of Response to Cognitive Behavioral Therapy in Depression and Anxiety Brain & Behavior Research Foundation (formerly NARSAD) The objective of this study is to broaden the clinical impact of an existing NIMH-funded K23 Career Development Award project by including individuals with major depressive disorder.  The project involves longitudinal fMRI and EEG measures of socio-emotional processing and emotion regulation before and after CBT. Clinical Cognitive Affective Neuroscience Lab Completed
Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety Disorder CBT is a widely used first-line treatment for social anxiety disorder (SAD), a prevalent, debilitating disorder. However, the specific mechanisms by which CBT exerts its therapeutic effects are unknown. The primary goal of this research is to elucidate the effects of CBT on brain function, particularly in relation to emotion regulation strategies implicated in CBT. Clinical Cognitive Affective Neuroscience Lab Completed
Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety Disorder K23MH093679 – National Institute of Mental Health Anxiety, Mood, Addiction Research Collaborative Completed
Neural Mechanisms of Attention-Emotion Interactions in Social Anxiety Disorder NIH UL1RR024986 This study uses fMRI to examine the neural correlates of attentional control over threat-relevant stimuli in individuals with social anxiety disorder. Clinical Cognitive Affective Neuroscience Lab Completed
Sleep Disturbance in Mood Disorders Across the Lifespan Campus Research Board Pilot Grant - University of Illinois at Chicago, Chicago, IL This study integrates actigraphy, an objective measure of sleep and activity-rest cycles, into several ongoing studies at the University of Illinois, which examine anxiety and mood disorders across the lifespan in order to test the feasibility of actigraphy. Clinical Cognitive Affective Neuroscience Lab Completed