- Associate Professor
- Department of Psychiatry
- University of Illinois at Chicago College of Medicine
- gpinna [at] uic.edu
- (312) 355-1464
School of Public Health / Psychiatric Institute (SPHPI)
1601 W. Taylor St.
SPHPI MC 912
Chicago IL 60612
- Room #:409
- Marianela Nelson
- Mechanism of action of antidepressant, anxiolytic, and antiaggressive drugs in several mouse models of affective/cognitive disorders, including aggressive behavior, schizophrenia, and PTSD
- Developing new therapies for PTSD and anxiety disorders
- Epigenetic mechanisms and psychiatric disorders, including schizophrenia
- Understanding emotional brain circuits that mediate cognitive and affective processes in PTSD mouse models
- Physiological role of neurosteroid allopregnanolone on GABAA receptor function
- Pharmacology of GABAA receptor modulators
- Mechanisms that lead to anabolic androgenic steroid (AAS)-induced behavioral deficits and the study of molecules that reverse the behavioral and neurochemical dysfunction induced by AAS treatment
- Function of GABAA receptors in mouse models of anxiolytic drug tolerance and dependence
Editor of Books
Fluoxetine:Pharmacology,Mechanisms of Action and Potential Side Effects.
Nova Publishers New York.(Editor:G.Pinna)
Agis-Balboa RC, Guidotti A, and Pinna G: Allopregnanolone biosynthesis is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients. Psychopharmacology. Submitted.
Pinna G: Targeting neurosteroidogenesis as therapy for PTSD. Frontiers in Pharmacology. Submitted.
Pinna G and Rasmusson AM: Upregulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioral deficits in a putative mouse model of PTSD. J. Neuroendocrinology. 24:102-16. 2012
Schüler Nin M, Martinez LA, Pibiri F, Nelson M and Pinna G: Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression. Front. Endocrin. 2:73. doi: 10.3389/fendo.2011.00073. 2011
Nelson M and Pinna G: S-norfluoxetine infused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology. 60:1154-1159. 2011
Pinna G: In a mouse model relevant for PTSD, selective brain steroidogenic stimulants (SBSSs) improve behavioral deficits by normalizing allopregnanolone biosynthesis. Behavioural Pharmacology. 21:438-450. 2010.
Pinna G, Costa E, and Guidotti A: SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Current Opinions in Pharmacology 9:24-30. 2009.
Pinna G, Agis-Balboa R, Pibiri F, Nelson M, Guidotti A, and Costa E: Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochemical Research. 33:1990-2007. 2008.
Pibiri F, Nelson M, Costa E, Guidotti A, and Pinna G: Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proc. Natl. Acad. Sci. USA 105:5567-5572. 2008. (media release: Click here.)
Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, and Guidotti A: Downregulation of 5a-reductase type I mRNA expression in cortico-limbic glutamatergic neurons in socially-isolated mice. Proc. Natl. Acad. Sci. USA. 104:18736-18741. 2007. (media release: Click here)
Pinna G, Agis Balboa RC, Zhubi A, Matsumoto K, Grayson DR, Costa E and Guidotti A: Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proc. Natl. Acad. Sci. USA 103:4275-4280. 2006.
Pinna G, Costa E, and Guidotti: Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses inactive on 5-HT reuptake. Psychopharmacology. 186:362-372. 2006.
Agis-Balboa RC, Pinna G, Zhubi A, Veldic M, Costa E and Guidotti A: Location and expression of brain enzymes catalyzing neurosteroid biosynthesis. Proc. Natl. Acad. Sci. USA 103:14602-14607. 2006.
Rasmusson AM, Pinna G, Weisman D, Paliwal P, Gottschalk C, Charney D, Krystal J and Guidotti A: Decreased cerebrospinal fluid allopregnanolone levels in women with PTSD. Biol. Psychiatry. 60: 704-713. 2006.
Pinna G, Costa E, and Guidotti A: Changes in brain testosterone and allopregnanolone elicit aggressive behavior. Proc. Natl. Acad. Sci. USA 102:2135-2140. 2005.
Pinna G, Costa E and Guidotti A: Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc. Natl. Acad. Sci. USA 101:6222-6225. 2004.
Pinna G, Dong E, Matsumoto K, Costa E and Guidotti A: In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc. Natl. Acad. Sci. USA 100:2035-2040. 2003
|Cyclical Neuroactive Steroid Changes, Arousal, and Proximal Suicide Risk: An Experimental Approach||R01-NIMH-120843 Experimentally delineating the neurosteroid pathways which may be involved in perimenstrual worsening of depression and suicide risk.||CLEAR – Eisenlohr-Moul Lab||On-going|
|04/16/2020||Molecular aspects of allopregnanolone’s pleitropic effects||Past Event|
|11/13/2019||Biomarkers and Drug Discovery: Allopregnanolone from Neuromodulator to Rapid-Acting Antidepressant||Past Event|