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  2. Erbo Dong

Erbo Dong PhD

Erbo Dong
Designation
  • Research Associate Professor
Contact Information
  • erbodong@uic.edu
  • (312) 413-4579
  • School of Public Health / Psychiatric Institute (SPHPI)
    1601 W. Taylor St.
    SPHPI MC 912
    Chicago IL 60612

Dr. Dong’s research has concentrated on furthering understanding the role of epigenetic mechanisms in the development of alcohol use disorder comorbid with mood disorders including anxiety and depression, focusing especially on the epigenetic modifications of molecules associated with synaptic formation, function and plasticity.

  • psychiatry

    Preclinical models of mental disorders
    Biomarkers of mental disorders
    Long non-coding and microRNAs in psychiatric disorders
    The complex interplay between stress and pathophysiological transformations associated with alcohol intake and comorbid disorders and possible pharmacological intervention.

  • Zheng Y, Fan W, Zhang X, Dong E.*Gestational Stress Induces Depression-like and Anxiety-like Phenotypes through Epigenetic Regulation of BDNF Expression in Offspring Hippocampus, Epigenetics(2016)11(2):150-62 (* corresponding author)

    Dong E, Tueting P, Matrisciano F, Grayson DR, Guidotti A. Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs. Translational Psychiatry (2016) 12;6:e711.

    Labouesse MA, Dong E, Grayson DR, Guidotti A, Meyer U. Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex. Epigenetics (2015) 10(12):1143-55

    Dong E., Ruzika WB., Grayson DR., Guidotti A.: DNA-methyltransferase 1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in brain of schizophrenia and bipolar disorder patients. Schizophr Res (2015) pii: S0920-9964(14)00599-4

    Dong E.*, Dzitoyeva S., Matrisciano F., Tueting P., Grayson DR., Guidotti A.: BDNF epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice. Biol Psych (2015) 77(6):589-596 (* corresponding author)

    Zhubi A., Chen Y., Dong E., Cook EH., Guidotti A., Grayson DR.: Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl Psychiatry (2014) 21;4:e349

    Auta J., Smith RC., Dong E., Tueting P., Sershen H., Boules S., Lajtha A., Davis JM., Guidotti A.: DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients. Schizophr Res (2013) 150(1):312-318

    Guidotti A., Dong E., Gavin DP., Veldic M., Zhao W., Bhaumik DK., Pandey SC., Grayson DR.: DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse. Alcohol Clin Exp Res (2013) 37(3):417-424

    Dong E.*, Gavin DP., Chen Y., Davis JM.: Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients. Transl Psychiatry(2012) 4;2:e159

    Gavin DP., Sharma RP., Chase KA., Matrisciano F., Dong E., Guidotti A.: Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis. Neuropsychopharmacology(2012) 37(2):531-542

    Matrisciano F., Dong E., Gavin DP., Nicoletti F., Guidotti A.: Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol Pharmacol (2011) 80(1):174-182

    Chen Y., Dong E., Grayson DR.: Analysis of the GAD1 promoter: trans-acting factors and DNA methylation converge on the 5'untranslated region. Neuropharmacology (2011) 60(7-8):1075-1087

    Dong E.*, Chen Y., Gavin DP., Grayson DR., Guidotti A.: Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics (2010) 22;5(8):730-735 (* corresponding author)

    Dong E., Nelson M., Grayson DR., Costa E., Guidotti A.: Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proc Natl Acad Sci USA (2008) 105(36):13614-13619

    Dong E., Guidotti A., Grayson DR., Costa E.: Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc Natl Acad Sci USA(2007) 104(11):4676-4681

    Simonini MV., Camargo ML., Dong E., Maloku E., Jones P., Veldic M., Guidotti A., Costa E.: The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases Proc Natl Acad Sci USA(2006) 103 (5):1587-1592

    Dong E., Agis-Balba R., Simonini MV., Grayson DR., Costa E., Guidotti A.: Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia Proc Natl Acad Sci USA (2005) 102 (35):12578-12583

    Tremolizzo L., Doueiri MS., Dong E., Grayson DR., Davis JM., Pinna G., Tueting P., Rodriguez-Menendez V., Costa E., Guidotti A.: Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry (2005) 57 (5):500-509

    Pinna G., Dong E., Matsumoto K., Costa E., Guidotti A.: In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci USA(2003)100(4):2035-2040

    Dong E., Caruncho H., Liu WS., Smalheiser NR., Grayson DR., Costa E., Guidotti A.: Reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci USA (2003) 100(9):5479-5484

    Dong E., Matsumoto K., Watanabe H.: Diazepam binding inhibitor (DBI) reduces testosterone and estradiol levels in vivo. Life Sci (2002) 70(11):1317-1323

    Dong E., Matsumoto K., Uzunova V., Sugaya I., Watanabe H., Costa E. and Guidotti A.: Brain 5a-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci USA(2001) 98(5):2849-2854.

    Dong E., Matsumoto K., Toda M., Kaneko Y., and Watanabe H.: Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice. Neuro Res (1999) 33(3):171-177

    Dong E., Matsumoto K., Toda M., and Watanabe H.: Possible involvement of diazepam binding inhibitor and its fragment octadecaneuropeptide in social isolation stress-induced decrease in pentobarbital sleep in mice. Life Sci (1999) 64(19):1779-1784

    Dong E., Matsumoto K., Toda M., Kaneko Y., and Watanabe H.: Involvement of peripheral type of benzodiazepine receptor in social isolation stress-induced decrease in pentobarbital sleep in mice. Life Sci(1999) 65(15):1561-1568

    (* corresponding author)

Title Description Investigator(s) Category Status
Epigenetic mechanisms Operative in Psychotic Disorders As part of our ongoing studies on the etiopathogenesis of schizophrenia and psychosis-related disorders, we have developed an animal model that mimics some of the behavioral and molecular endophenotypes associated with these disorders. Psychiatric Institute On-going
Histone modifications and gender differences in alcoholism This proposal will test the hypothesis that sex differences in alcohol consumption in adulthood may be related to prenatal stress-induced lasting changes in epigenetic (histone code-acetylation and methylation) control on transcriptional regulation of genes related to synaptic plasticity in the cortico- limbic reward system using animal model. Alcohol Research Center On-going