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  2. Edwin H. Cook Jr.

Edwin H. Cook Jr. MD

Edwin H. Cook Jr.
Designation
  • Earl M Bane Professor of Psychiatry
  • Associate Head, Clinical Services
  • Director, Program for Neurodevelopmental Disorders
Contact Information
  • edcook [at] uic.edu
  • (312) 413-4537
  • Institute for Juvenile Research (IJR)
    1747 W. Roosevelt Rd.
    Chicago IL 60612
Website

Dr. Cook is the Director of Program for Neurodevelopmental Disorders and the Associate Head of Clinical Services in the department. Dr. Cook is board certified in both Psychiatry and Child and Adolescent Psychiatry. He specializes in treating comorbid psychiatric disorders for individuals with autism spectrum disorder. Dr. Cook is also the Earl M. Bane Professor of Psychiatry.

  • psychiatry

    Neurodevelopmental disorders, Genetic research on child onset neuropsychiatric disorders.

  • Autism Center of Excellence

    Interdisciplinary Studies of Insistence on Sameness (IS) in Autism Spectrum Disorders (ASD) 

    With a grant from the Eunice Kennedy Shriver National Institute of Child Health and Development of NIH, the UIC ACE focuses on an interdisciplinary, translational program of research, from gene to biochemistry to neurophysiology to behavior. Specifically, our group is investigating the pathophysiology and treatment of insistence on sameness in autism. Over 250 families are expected to participate by the end of the current period of support in the summer of 2012.

    Click here for more information.


  • Center for Neurodevelopmental Disorders

    The Center for Neurodevelopmental Disorders is the site of the Autism Center of Excellence, one of the original 6 research centers funded by the Eunice Kennedy Shriver National Institute of Child Health and Development of NIH. The Center focuses on determining the causes of autism and related disorders and contributing to development of new treatments. 

    Click here for more information.


  • Cook, E.H.: Autism: Review of neurochemical investigation. Synapse 1990,6:292 308.

    Cook, E.H., Lindgren, V., Leventhal, B.L., Courchesne, R., Lincoln, A., Shulman, C., Lord, C., Courchesne, E.: Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. American Journal of Human Genetics 1997,60:928-934.

    Cook, Jr., E.H., Scherer, S.W.: Copy-number variations associated with neuropsychiatric conditions. Nature, 2008,455:919-923.

    Kumar, R.A., Karamohamed, S., Sudi, J., Conrad, D.F., Brune, C., Badner, J.A., Gilliam, T.C., Nowak, N.J., Cook E.H., Dobyns, W.B., Christian, S.L.: Recurrent 16p11.2 microdeletions in autism. Human Molecular Genetics 2008,17:628-638.

    Wakschlag, L.S., Kistner, E.O., Pine, D.S., Biesecker, G., Pickett, K.E., Skol, A., Dukic, V., Blair, R.J., Leventhal, B.L., Cox, N., Burns, J., Kasza, K.E., Wright, R.J., Cook, E.H.: Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Molecular Psychiatry, 2010,15:928-937. PMC2905677.

    Kistner-Griffin, E., Brune, C.W., Davis, L.K., Sutcliffe, J.S., Cox, N.J., Cook, E.H.: Parent-of-origin effects of the serotonin transporter gene associated with autism. American Journal of Medical Genetics (Neuropsychiatric Genetics), 2011,156:139-144. PMC3438509.

    Sanders, S.J., Ercan-Sencice, A.G., Hus, V., Luo, R., Murtha, M.T., Moreno-De-Luca, S., Chu, S.H., Moreau, M.P., Gupta, A.R., Thomson, S.A., Mason, C.E., Bilguvar, K., Celestino-Soper, P.B.S., Choi, M., Crawford, E.L., Davis, L., Davis Wright, N.R., Dhodapkar, R.M., DiCola, M., DiLullo, N.M., Fernandez, T.V., Fielding-Singh, V., Fishman, D.O., Frahm, S., Garagaloyan, R., Goh, G.S., Kammela, S., Klei, L., Lowe, J.K., Lund, S.C., McGrew, A.D., Meyer, K.A., Moffat, W.J., Murdoch, J.D., O'Roak, B.J., Ober, G.T., Pottenger, R.S., Raubeson, M.J., Song, Y., Wang, Q., Yaspan, B.L., Yu, T.W., Yurkiewicz, I.R., Beaudet, A.L., Cantor, R.M., Curland, M., Grice, D.E., Günel, M., Lifton, R.P., Mane, S.M., Martin, D.M., Shaw, C.A., Sheldon, M., Tischfield, J.A., Walsh, C.A., Morrow, E.M., Ledbetter, D.H., Fombonne, E., Lord, C., Martin, C.L., Brooks, A.I., Sutcliffe, J.S., Cook, Jr., E.H., Geschwind, D., Roeder, K., Devlin, B., State, M.W.: Multiple recurrent de novo copy number variations (CNVs), including duplications of the 7q11.23 Williams-Beuren syndrome region, are strongly associated with autism. Neuron, 2011,70: 863-885.

    Hammock, E., Veenstra-VanderWeele, J., Yan, Z., Kerr, T.M., Morris, M., Anderson, G.M., Carter, C.S., Cook, E.H., Jacob, S.: Examining autism spectrum disorders by biomarkers: example from the oxytocin and serotonin systems. Journal of the American Academy of Child and Adolescent Psychiatry, 2012,51:712-721. PMC3672055.

    Neale, B.M., Kou, Y., Liu, L., Ma’ayan, A., Samocha, K.E., Sabo, A., Lin, C-F., Stevens, C., Wang, L-S., Makarov, V., Polak, P., Yoon, S., Maguire, J., Crawford, E.L., Campbell, N.G., Geller, E.T., Valladares, O., Shafer, C., Liu, H., Zhao, T., Cai, G., Lihm, J., Dannenfelser, R., Jabado, O., Peralta, Z., Nagaswamy, U., Reid, J.G., Newsham, I., Wu, Y., Lewis, L., Han, Y., Muzny, D., Voight, B.F., Lim, E., Rossin, E., Kirby, A., Flannick, J., Fromer, M., Shakir, K., Fennell, T., Garimella, K., Boyko, C., Gabriel, S., dePristo, M., Wimbish, J.R., Boone, B.E., Levy, S.E., Betancur, C., Sunyaev, S., Boerwinkle, E., Buxbaum, J.D., Cook, E.H., Devlin, B., Gibbs, R., Roeder, K., Schellenberg, G.D., Sutcliffe, J.S., Daly, M.J.: Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature, 2012,485:242-245. PMC3613847.

    D'Cruz, A.M., Ragozzino, M.E., Mosconi, M.W., Shrestha, S., Cook, E.H., Sweeney, J.A.: Reduced behavioral flexibility in autism spectrum disorders. Neuropsychology 2013,27:152-160. PMC3740947.

Title Description Investigator(s) Category Status
Laboratory of Developmental Neuroscience The Laboratory of Developmental Neuroscience is dedicated to studying the developmental neurobiological basis of pediatric onset neuropsychiatric disorders. We use neurochemical and molecular genetic research tools to develop new knowledge that may lead to improvement in clinical pharmacology. Program for Neurodevelopmental Disorders On-going
Samples and Phenotype Committee Leadership in the Autism Sequencing Consortium Along with Catalina Betancur (France) and Louise Gallagher (Ireland), the Samples and Phenotypes Committee works with the larger Autism Sequencing Consortium to identify new genetic variants in autism spectrum disorder and to understand the relationship of genetic variation in ASD to phenotype. Program for Neurodevelopmental Disorders On-going