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Amynah Pradhan PhD

Amynah Pradhan
Designation
  • Associate Professor
Contact Information
  • pradhan4 [at] uic.edu
  • (312) 355-1557
  • School of Public Health / Psychiatric Institute (SPHPI)
    1601 W. Taylor St.
    SPHPI MC 912
    Chicago IL 60612
  • Room #:Room 464
Website

Dr. Pradhan’s research focuses on the neuropharmacology of opioid receptors. She received her PhD in Pharmacology and Therapeutics from McGill University, where she studied the behaviorally relevant populations of mu and delta opioid receptors, and interactions between them. Dr. Pradhan then did a postdoctoral fellowship at AstraZeneca Montreal, where she helped characterize a novel protein involved with pain processing. During her subsequent fellowship at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France, she pursued her interest in the behavioral consequences of delta opioid receptor trafficking and signaling. Immediately prior to joining the faculty of UIC, Dr. Pradhan was a postdoctoral fellow at the University of California Los Angeles, where she explored the role of beta-arrestin scaffold proteins on delta opioid receptor signaling. During this time, she also developed an interest in the role of opioid receptors in migraine.

  • psychiatry

    Dr. Pradhan studies the neurobiology of opioid receptors. In particular, her lab seeks to elucidate the cellular signaling events that regulate behavioral effects of delta opioid receptor activation. Her lab is also conducting research exploring the role of opioid receptors in migraine. Overall, Dr. Pradhan aims to translate in vitro findings to animal behavioral models, with the ultimate goal of translating those results to clinical applications, particularly for the treatment of emotional disorders and pain.

  • NIH/NIDA In vivo implications of ligand-specific activation of delta opioid receptor.Neurobiology of Migraine

  • Ben Aissa M, Tipton AF, Bertels Z, Gandhi R, Moye LS, Novack M, Bennett BM, Wang Y, Litosh V, Lee SH, Gaisina IN, Thatcher GR, Pradhan AA*. (2017) “Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.” Cephalalgia. epub ahead of print.

    Shiwarski DJ, Tipton A, Giraldo MD, Schmidt BF, Gold MS, Pradhan AA, Puthenveedu MA. (2017) “A PTEN-regulated checkpoint regulates surface delivery of delta opioid receptors.” Journal of Neuroscience. Mar 6, epub ahead of print.

    L. Segura, A.A. Pradhan*. (2017) “From blast to bench: a translational mini-review of post-traumatic headache.” Journal of Neuroscience Research. Feb 2, epub ahead of print.

    L.S. Moye & A.A. Pradhan. (2017) Animal Model of Chronic Migraine-Associated Pain. Current Protocols in Neuroscience. 2017 Jul 5;80:9.60.1-9.60.9.

    A. Vicente-Sanchez & A.A. Pradhan. (2017) Ligand directed signaling at the delta opioid receptor. Book Chapter for The Delta Opioid Receptor. To be published by Springer. Jul 9.In Press.

    Cahill CM, Walwyn W, Taylor AM, Pradhan AA, Evans CJ.  (2016) Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation. Trends in Pharmacological Sciences. 37(11):963-976.

    A. Vicente-Sanchez, L. Segura, A.A. Pradhan*. (2016) The Delta Opioid Receptor Tool Box. Neuroscience. 338:145-159.

    A.A. Pradhan*, J. Perroy, W. Walwyn, M. Smith, A. Vicente-Sanchez, L. Segura, A. Bana, B. Kieffer, C. Evans. (2016) Agonist-selective recruitment of arrestin isoforms differentially modify delta opioid receptor function. Journal of Neuroscience. 36(12):3541–3551.

    A.F. Tipton, I. Tarash, B. McGuire, A. Charles, A.A. Pradhan*. (2016) The effects of acute and preventive migraine therapies in a mouse model of chronic migraine. Cephalalgia. 36(11)1048-1056.

    A. Charles & A.A. Pradhan. (2016) Delta-opioid receptors as targets for migraine therapy. Current Opinion in Neurology. 29(3):314-9.

    A.M Taylor, A. Castonguay, A. Ghogha, P. Vayssiere, A.A. Pradhan, L. Xue, S. Mehrabani, J. Wu, P. Levitt, M.C. Olmstead, Y. De Koninck, C.J. Evans, C.M. Cahill. (2015) Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine. Neuropsychopharmacology.  41(4):949-59.

    S.L. Bowersox, A.L. Soohoo, D.J. Shiwarski, S. Shulz, A.A. Pradhan, M.A. Puthenveedu. Cell-autonomous tuning of opioid sensitization by Substance P.  (2015) Cell Reports.  10(11):1925-36.

    A.A. Pradhan, V.Tawfik, A. Laboy, G Scherrer.  (2015) In vivo techniques to investigate the internalization profile of opioid receptors. Book chapter for Opioid Receptors: Methods and Protocols. Published by Springer Methods in Molecular Biology Series.

    A. Taylor, K. Roberts, A.A. Pradhan, W.Walwyn, K. Lutfy, H. Akbari, F.I. Carroll, C.M. Cahill, C.J. Evans.  (2014) Kappa opioid receptor-mediated analgesia is blocked by a delta opioid receptor agonist. British Journal of Pharmacology. 172(2):691-703.

    A.A. Pradhan*, M. Smith, J. Zyuzin, and A. Charles. (2014)  Delta Opioid Receptor Agonists Inhibit Migraine-Related Pain, Aversive State, and Cortical Spreading Depression. British Journal of Pharmacology 171(9):2375-84. *senior corresponding author

    A.A. Pradhan*, M. Smith, B. McGuire, I. Tarash, C. Evans, and A. Charles. (2014)  Characterization of a Novel Model of Chronic Migraine.  Pain 155(2):269-74. *senior corresponding author

Title Description Investigator(s) Category Status
Epigenetic regulation of migraine The aim of this research is to understand the role of histone deacetylases in headache disorders. Amynah Pradhan Lab On-going
Overlapping mechanisms between opioid induced hyperalgesia and chronic migraine The aim of these studies is to identify the transcriptomic and peptidomic links between opioid use and migraine chronification. Amynah Pradhan Lab On-going
The role of delta opioid receptors in trigeminovascular pain NIH-NIDA R01 DA040688 The aim of this proposal is to determine the role of delta opioid receptors in trigeminovascular pain (migraine). Specifically, we will characterize the anatomically relevant populations of delta opioid receptor using conditional knockout mice in different mechanistic models of migraine. Amynah Pradhan Lab On-going
In Vivo Implications of Agonist Selective Activation of Delta Opioid Receptor NIH-NIDA R00 DA031243 Delta opioid receptor agonists are currently being developed for the treatment of pain and emotional disorders. However, a sub-population of delta opioid receptor agonists also produce convulsions, a major deterrent to the development of these compounds. The goal of these studies was to determine the mechanism that accounts for this ligand-specific effect.  Amynah Pradhan Lab Completed
Mitochondrial epigenome and alcohol withdrawal-induced pain The proposed studies will establish the effect of chronic ethanol on the mitochondrial epigenome, and determine if these interactions produce ethanol withdrawal-induced pain. Alcohol Research Center Completed
Date Released Title Source
01/14/2020 Dr. Amynah Pradhan is the new Director of the Graduate Program in Neuroscience at UIC
07/11/2016 Dr. Amynah Pradhan won the Young Investigators Award 2016 International Narcotics Research Conference (INRC)
07/11/2016 Dr. Amynah Pradhan won the Young Investigators Award 2016 British Pharmacological Society