University of Illinois at Chicago
Department of Psychiatry
912 S. Wood Street, (M/C 913)
Chicago, IL 60612
Office Phone: (312) 355-5017
Rubin, L.H., Meyer, V.J., Jamadar, R., Sundermann, E.E., Wu, M., Weber, K.W., Cohen, M.H., Little, D.M., & Maki, P.M. (2015). Prefrontal cortical volume loss is associated with stress-related deficits in verbal learning and memory in HIV-infected women. Neurobiology of Disease. PMID: 26408051
Rubin, L.H., Pyra, M.Cook, J.A., Weber, K.M., Cohen, M.H., Martin, E., Valcour, V., Milam, J., Anastos, K., Young, M.A., Alden, C., Gustafson, D.R., Maki, P.M. (2015). Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women. Journal of Neurovirology. PMID: 2640443
Rubin, L.H., Carter, C.S., Drogos, L.L., Pournajafi-Nazarloo, H., Sweeney, J.A., & Maki, P.M. (2015). Effects of sex, menstrual cycle phase, and endogenous hormones on cognition in schizophrenia. Schizophrenia Research, 166(1-3):269-75. PMID: 25990704; PMCID: PMC4512858
Rubin, L.H. Cook, J.A., Weber, K.M., Cohen, M.H., Martin, E., Valcour, V., Milam, J., Anastos, K., Young, M.A., Alden, C., Gustafson, D.R., & Maki, P.M. (2015). The association of perceived stress and verbal memory is greater in HIV-infected versus HIV-uninfected women. Journal of Neurovirology, 21(4), 422-432. PMID: 25791344
Valcour, V. Rubin, L.H., Tien, P., Anastos, K., Young, M., Mack, W., Cohen, M., Golub, E.T., Crystal, H., & Maki, P.M. (2015). Human Immunodeficiency Virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: A study of the Women’s Interagency HIV Study (WIHS). Journal of Neurovirology, 21(4):415-21. PMID: 25740539; PMCID: PMC4511712
Rubin, L.H. and Maki, P.M. (2015). Elucidating postpartum depression through statistics: The value of classification methods. Lancet Psychiatry, 2 (1), 6-8. PMID: 26404435
Sundermann, E.E., Bishop, J.R., Rubin, L.H., Little, D.M., Meyer, V.J., Martin, E., Weber, K., Cohen, M., & Maki, P.M. (2014). Genetic Predictor of Working Memory and Prefrontal Function in Women with HIV. Journal of Neurovirology, 21(1): 81-91. PMID: 25515329; PMCID: PMC4319991
Maki, P.M., Rubin, L.H., Valcour, V., Martin, E., Crystal, H.A, Young, M., Weber, K.M., Manly, J., Richardson, J., Alden, C. & Anastos, K. (2014) Cognitive function in women with HIV: Findings from the Women’s Interagency HIV Study. Neurology, 84(3): 231-240. PMID: 25540304; PMCID: PMC4335997
Rubin, L.H., Sundermann, E.E., Cook, J.A., Martin, E.M., Golub, E.T., Weber, K.M., Cohen, M.H., Crystal, H., Cederbaum, J.A., Anastos, K., Young, M., Greenblatt, R.M., & Maki, P.M. (2014). An investigation of menopausal stage and symptoms on cognition in HIV-infected women. Menopause, 21(9):997-1006. PMID: 24496085; PMCID: PMC4119867
Rubin, L.H., Haas, G., Keshavan, M., Sweeney, J.A., & Maki, P.M. (2008). Sex differences in cognitive response to antipsychotic treatment. Neuropsychopharmacology, 33(2), 290-297. PMID: 17392734
Rubin, L.H., Carter, C.S., Drogos, L., Pournajafi-Nazarloo, H.P., Sweeney, J.A., & Maki, P.M. (2010). Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophrenia Research, 124, 13-21. PMID: 20947304; PMCID: PMC2981685
Rubin, L.H., Carter, C.S., Drogos, L., Jamadar, R., Pournajafi-Nazarloo, H.P., Sweeney, J.A., & Maki, P.M. (2011). Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia. Schizophrenia Research, 130, 266-270. PMID: 21684122; PMCID: PMC3139729
Rubin, L.H., Carter, C.S., Bishop, J.R., Pournajafi-Nazarloo, H., Harris, M.S., Hill, S.K., Reilly, J.L., & Sweeney, J.A. (2013). Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with untreated first-episode psychosis. Schizophrenia Research, 146(1-3), 138-43. PMID: 23465965; PMCID: PMC3622845
Rubin, L.H., Carter, C.S., Bishop, J.R., Pournajafi-Nazarloo, H., Drogos, L.L., Hill, S.K., Ruocco, A.C., Keedy, S.K., Reilly, J.L., Keshavan, M.S., Pearlson, G.D., Tamminga, C.A., Gershon, E.S., & Sweeney, J.A. (2014) Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophrenia Bulletin, 40(6): 1374-84. PMID: 24619535
Leah H. Rubin, PhD
Dr. Leah Rubin is an Assistant Professor in the Department of Psychiatry and Women’s Mental Health Research Program at the University of Illinois at Chicago. Dr. Rubin’s program of research elucidates neuroendocrine mechanisms contributing to mental and cognitive health in women. She focuses on the effect of sex steroid hormones, glucocorticoids, vasopressin, and oxytocin on cognition and mental health in healthy women, women living with HIV, and female psychiatric patients. A central long-term goal is to improve the cognitive health of HIV-infected women and women with psychiatric illnesses through an interdisciplinary research career that incorporates epidemiological, mechanistic, and intervention science.
In Dr. Rubin’s NIMH-funded HIV work, she focuses specifically on the detrimental effects of stress (perceived stress, post-traumatic stress), psychiatric comorbidities, and stress hormones on cognition and brain function in HIV-infected women at both the epidemiological and mechanistic levels (e.g., pharmacological challenge studies). As part of her work she has developed and applied sophisticated statistical approaches to assess the influence of HIV on cognitive functioning. She is an active member of the Neurocognitive Working Group (NCWG) of the Women’s Interagency HIV Study (WIHS), the nation’s largest prospective study of the natural and treated history of HIV in women.
Dr. Rubin also pursues programmatic investigations to better understand sex differences in psychosis through the exploration of hormonal contributions to this mental illness. To date, she has focused on the effects of sex steroid hormones, oxytocin, and vasopressin in first-episode schizophrenia, chronic schizophrenia, and more recently in probands and relatives with psychosis (Bipolar-Schizophrenia Network on Intermediate Phenotypes: B-SNIP). This line of work will hopefully have lasting impact in women’s health as the end goal of this research is to identify sex-specific, neurohormonal treatments for mental illness and to improve the lives of individuals with severe mental illness.
Hormonal contributors to mental and cognitive health, women with HIV, stress, perinatal depression, biostatistics, psychoneuroendocrinology.
Education and Training:
Ph.D., Cognitive Psychology, University of Illinois at Chicago, 2009
M.A., Clinical Psychology, Loyola University, Maryland, 2002