Research
Schizophrenia Cognition

Investigators: Martin Harrow, Ph.D., Ellen Herbener, Ph.D., Linda Grossman, Ph.D., Eileen Martin, Ph.D., Thomas Jobe, M.D., Kalman Kaplan, Ph.D., Joanne Marengo, Ph.D., Joe Goldberg, M.D.

The goal of the overall research project is to further our knowledge about schizophrenia, bipolar disorder and other major psychoses by a prospective longitudinal investigation involving a 20 year follow-up of a sample of patients previously studied prospectively at the acute phase, and followed up five times over a fifteen year period.

A large sample of young patients with non-chronic schizophrenia and schizoaffective disorders, bipolar affective disorders, unipolar psychotic and non-psychotic depressive disorders are being assessed longitudinally. Patients have been evaluated at the acute phase, and are being followed up at various phases over the years for delusions, hallucinations, disordered thinking, neuropsychological deficits, and negative symptoms. They also are being assessed for affective symptoms, rehospitalization, substance abuse, social and work adjustment, and suicidal activity. The data are used to evaluate a number of theories about psychosis, thought disorder, negative symptoms, prognostic factors, and suicidal behavior. The data are being utilized to advance knowledge about the long-term clinical course and level of functioning and adjustments in modern-day schizophrenia and bipolar disorders.