Currently, approximately 50% of individuals who experience depression during their adolescence experience depression again. No current treatment protects against the lifelong consequences of depression in one’s youth. This project seeks to therapeutically modulate the brain circuitry underlying rumination, a passive and maladaptive thought pattern, for the purposes of reducing risk for the recurrence of depression in adolescents. In addition to assessing the impact of a novel relapse prevention program (rumination-focused cognitive behavior therapy; R-CBT); this study will examine the neural systems of the brain that support rumination. R-CBT has recently been tested in the prevention of first-onset depression among adolescent girls, with an observed decrease in depression scores of approximately 30%. R-CBT has also been effective in reducing depression among adults.