K. Luan Phan, MD


Dept. of Psychiatry,
University of Illinois at Chicago
1747 W. Roosevelt Rd., WROB/IJR Rm. 244, Chicago, IL 60608,

Office Phone: 312-355-5954
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Assistant:Barbara Johnson
Phone: (312) 355-2301
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.


Maren S, Phan KL, Liberzon I (2013). The Contextual Brain: Implications for Fear Conditioning, Extinction, and Psychopathology. Nature Reviews Neuroscience 14(6):417-28

Klumpp H, Fitzgerald DA, Phan KL (2013). Neural Predictors and Mechanisms of Cognitive Behavioral Therapy on Threat Processing in Social Anxiety Disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 45C:83-91

Phan KL, Coccaro EF, Angstadt M, Kreger KJ, Mayberg HS, Liberzon I, Stein MB (2013). Corticolimbic Brain Reactivity to Social Signals of Threat Before and After Sertraline Treatment in Generalized Social Phobia.  Biological Psychiatry 73(4):329-36.

Gorka SM, Fitzgerald DA, King AC, Phan KL (2013). Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: A preliminary pharmaco-fMRI study.  Psychopharmacology

Rabinak CA, Angstadt M, Welsh RC, Kennedy A, Martis B, Lyubkin M, Phan KL (2011). Altered amygdala resting-state functional connectivity in post-traumatic stress disorder.  Frontiers in Neuropsychiatric Imaging and Stimulation 2:62, 1-8.

Phan KL, Sripada CS, Angstadt M, McCabe K (2010). Reputation for reciprocity engages the brain’s reward center. Proceedings of the National Academy of Sciences 107(29):13099-104.

Phan KL, Orlichenko A, Angstadt M, Boyd E, Coccaro E, Liberzon I, Arfanakis K (2009).  Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder.  Biological Psychiatry 66(7):691-4.

Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H (2008). Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans. Journal of Neuroscience 28(10):2313-2319.

Banks S, Eddy K, Angstadt M, Nathan PJ, Phan KL (2007).  Amygdala-frontal connectivity during emotion regulation.   Social Cognitive Affective Neuroscience 2: 303-312.

Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006).  Association between amygdala hyperactivity to harsh faces and severity of social anxiety symptoms in generalized social phobia.  Biological Psychiatry 59:424-429.

Phan KL, Taylor SF, Fig LM, Britton JC, Liberzon I (2006).  Corticolimbic blood flow during non-traumatic emotional processing in posttraumatic stress disorder.  Archives of General Psychiatry 63:184-192.

Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS, Swain JE, Liberzon I, Phan KL (2013).Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. Proceedings of the National Academy of Sciences 110(46):18442-7


K. Luan Phan, MD

Professor of Psychiatry

Dr. K. Luan Phan is Director of the Mood and Anxiety Disorders Clinical and Research Programs and Associate Head for Clinical and Translational Research in the Department of Psychiatry at the University of Illinois at Chicago.  He is also Chief of NeuroPsychiatric Research and a VA Research Scientist at the Jesse Brown VA Medical Center.  He has a longstanding commitment to translate discoveries from affective and cognitive neuroscience to improve our understanding and treatment of anxiety and mood disorders.

Lab/Research Program website: http://www.psych.uic.edu/research/mood-and-anxiety-disorders-research-program

Patient-oriented research in his interdisciplinary Research Program crosses both UIC and the VA and aims to discover the behavioral and brain mechanisms that implement the regulation of affect and motivational salience in humans.  Using these discoveries of mechanisms, his group defines the brain targets to make treatments better and to innovate new interventions for mood and anxiety disorders.  The Research Program integrates affective, cognitive, and social neuroscience perspectives using a multi-level analytic approach from internal milieu to peripheral psychophysiology to (c)overt actions to brain function to pharmacologic manipulation to clinical trials. The group primarily uses magnetic resonance imaging (fMRI, DTI, sMRI) and electroencephalography (EEG) of event-related potentials (ERP) as predominant tools to assess brain circuit function as they relate to emotion, affect rgulation and motivation. The Research Program studies patients across the lifespan, from childhood to adulthood and appreciates a longitudinal view of illness, from emergence of illness and to recovery.

Dr. Phan received his medical degree from the University of Michigan in Ann Arbor and received psychiatry residency and research track training at the Western Psychiatric Institute and Clinics at the University of Pittsburgh and at the University of Michigan Hospitals and Clinics.  Prior to joining the faculty at the University of Illinois at Chicago in 2012, he was Associate Professor in the Department of Psychiatry and Neuroscience Program at the University of Michigan and Chief of the Mental Health Clinic at the Ann Arbor VA Healthcare System.

Dr. Phan has been awarded the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on outstanding scientists and engineers in the early stages of their independent research career. Dr. Phan’s research has been consistently funded by the National Institutes of Health, Veterans Affairs, and Department of Defense over the past 10 years.  He has over 95 peer-reviewed publications, in journals such as Archives of General Psychiatry, Biological Psychiatry, American Journal of Psychiatry, Neuropsychopharmacology, Proceedings of the National Academy of Sciences, and Journal of Neuroscience. Dr. Phan also serves as Associate Editor for several journals (Biology of Mood and Anxiety Disorders, BMC Psychiatry, Frontiers in Psychiatry).  Currently, he is a standing member of the NIMH Study Section Interventions Committee for Adult Disorders (ITVA), member of the Scientific Council of the Anxiety and Depression Association of America, and member of the Scientific Program Committee of the Society of Biological Psychiatry.


American College of Neuropsychopharmacology (ACNP); Society of Biological Psychiatry (SOBP); Anxiety and Depression Association of America (ADAA); Society for Neuroscience (SFN)


Research Themes:

1)  Functional Neuroanatomy of Emotion, Cognition, and Decision Making

2)  Functional Neuroanatomy Mood and Anxiety Disorders

3)  Neurofunctional Markers of Treatment Response in Mood and Anxiety Disorders

4)  Functional Neuroimaging of Drug Effects on Affective Experience and Cognition