Schizophrenia and Affective Disorders


Laboratory for the Study of Schizophrenia and Affective Disorders

Martin Harrow, Ph.D.

Martin Harrow, Ph.D., Linda Grossman, Ph.D., Thomas Jobe, MD, Joseph Goldberg, MD, Cherise Rosen, Ph.D., Robert Faull, B.S.

The goal of the overall research project is to further our knowledge about schizophrenia and other major psychotic disorders by a prospective longitudinal investigation involving a 26 year followup of a large sample of patients previously studied prospectively at the acute phase, and already followed up six times over the first twenty years.

A large sample of young patients with schizophrenia and affective disorders, including bipolar affective disorders, unipolar psychotic and nonpsychotic depressive disorders have been assessed longitudinally. Patients have been evaluated at the acute phase and are being followed up at various phases over the years for delusions, hallucinations, disordered thinking, neurocognitive deficits, and negative symptoms. They are also being assessed for affective symptoms, rehospitalizations, substance abuse, social and work adjustment, and suicidal activity. The data are used to evaluate a number of theories about psychosis, thought disorder, negative symptoms, prognostic factors, premorbid developmental achievements and antipsychotic medications. They are also being used to assess the long-term clinical course and level of functioning and adjustment in modern-day schizophrenia and bipolar disorders, with a special focus on issues such as work disability and the potential to experience periods of recovery.