UIC Department of Psychiatry

CONTACT INFORMATION

Dept. of Psychiatry,
University of Illinois at Chicago
1747 W. Roosevelt Rd., WROB/IJR Rm. 244, Chicago, IL 60608,

Office Phone: 312-355-5954
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Assistant: Barbara Johnson
Phone: (312) 355-2301
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KEY PUBLICATIONS

Rabinak CA, Angstadt M, Welsh RC, Kennedy A, Martis B, Lyubkin M, Phan KL (2011). Altered amygdala resting-state functional connectivity in post-traumatic stress disorder.  Frontiers in Neuropsychiatric Imaging and Stimulation 2:62, 1-8. 

Klumpp H, Angstadt M, Phan KL (2012). Insula Reactivity and Connectivity to Anterior Cingulate Cortex to Threat in Generalized Social Anxiety Disorder.  Biological Psychology 89(1):273-6.

Labuschagne I, Phan KL, Angstadt M, Chua P, Wood A, Heinrichs M, Nathan PJ (2010). Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder.  Neuropsychopharmacology 35(12):2403-13. 

Phan KL, Sripada CS, Angstadt M, McCabe K (2010). Reputation for reciprocity engages the brain’s reward center. Proceedings of the National Academy of Sciences 107(29):13099-104. 

King A, McNamara P, Angstadt M, Phan KL (2010). Neural Substrates of Alcohol-Induced Smoking Urge in Heavy Drinking Nondaily Smokers. Neuropsychopharmacology 35(3):692-701. 

Phan KL, Orlichenko A, Angstadt M, Boyd E, Coccaro E, Liberzon I, Arfanakis K (2009). Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder.  Biological Psychiatry 66(7):691-4.

Kerestes R, Labuschagne I, Croft RJ, O’Neill, Bhagwagar Z, Phan KL, Nathan P (2009). Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study.  Psychopharmacology 202(4):621-34.

Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H (2008). Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans. Journal of Neuroscience 28(10):2313-2319.

Banks S, Eddy K, Angstadt M, Nathan PJ, Phan KL (2007).  Amygdala-frontal connectivity during emotion regulation.  Social Cognitive Affective Neuroscience 2: 303-312.

Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006).  Association between amygdala hyperactivity to harsh faces and severity of social anxiety symptoms in generalized social phobia.  Biological Psychiatry 59:424-429.

Phan KL, Taylor SF, Fig LM, Britton JC, Liberzon I (2006).  Corticolimbic blood flow during non-traumatic emotional processing in posttraumatic stress disorder.  Archives of General Psychiatry 63:184-192.

 

K. Luan Phan, MD

Professor of Psychiatry

Dr. K. Luan Phan is Director of the Mood and Anxiety Disorders Program and Associate Head for Clinical and Translational Research in the Department of Psychiatry at the University of Illinois at Chicago.  He is also a VA Research Career Scientist and Chief of NeuroPsychiatric Research at the Jesse Brown VA Medical Center.  He has a longstanding commitment to translate discoveries from affective and cognitive neuroscience to improve our understanding and treatment of anxiety and mood disorders.

Patient-oriented research in his interdisciplinary Mood and Anxiety Disorders Research Program which crosses both UIC and the VA aims to discover the behavioral and brain mechanisms that implement the regulation of affect and motivation in humans.  Using these discoveries of mechanisms, his group defines the targets to refine how we deliver existing treatments and to innovate new treatments for mood and anxiety disorders.  The Research Program integrates affective, cognitive, and social neuroscience perspectives using a multi-level analytic approach from internal milieu to peripheral psychophysiology to (c)overt actions to brain function to pharmacologic manipulation to clinical trials. The group uses magnetic resonance imaging (fMRI, DTI, sMRI) and electroencephalography (EEG) as predominant tools to assess brain circuit function as they relate to emotion and motivation. The Research Program studies patients across the lifespan, from childhood to adulthood and appreciates a longitudinal view of illness, from emergence of illness and to recovery.

Dr. Phan received his medical degree from the University of Michigan in Ann Arbor and received psychiatry residency and research track training at the Western Psychiatric Institute and Clinics at the University of Pittsburgh and at the University of Michigan Hospitals and Clinics.  Prior to joining the faculty at the University of Illinois at Chicago in 2012, he was Associate Professor in the Department of Psychiatry and Neuroscience Program at the University of Michigan and Chief of the Mental Health Clinic at the Ann Arbor VA Healthcare System.

Dr. Phan’s research has been consistently funded by the National Institutes of Health, Veterans Affairs, and Department of Defense.  He has over 80 peer-reviewed publications, and serves as Associate Editor for several journals including Biology of Mood and Anxiety Disorders; BMC Psychiatry; Frontiers in Psychiatry; Social Neuroscience.  Currently, he is a member of the Scientific Council of the Anxiety and Depression Association of America, and member of the Scientific Program Committee of the Society of Biological Psychiatry.

Interests:
Cognitive behavioral therapy, anxiety disorders, PTSD, panic disorder, post-deployment health issues, anxiety and health outcomes including cardiovascular disease.

Research Themes:

1)  Functional Neuroanatomy of Emotion, Cognition, and Decision Making

2)  Functional Neuroanatomy Mood and Anxiety Disorders

3)  Neurofunctional Markers of Treatment Response in Mood and Anxiety Disorders

4)  Functional Neuroimaging of Drug Effects on Affective Experience and Cognition