CONTACT INFORMATION
Department of PsychiatryUniversity of Illinois at Chicago
1601 West Taylor Street,
Chicago, IL 60612
Office Phone: 312-413-4557
Fax:
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
KEY PUBLICATIONS
Dwivedi Y. Evidence demonstrating role of microRNAs in the etiopathology of major depression. J Chem Neuroanatomy 2011, in press http://dx.doi.org/10.1016/j.jchemneu.2011.04.002.
Dwivedi Y., Pandey GN. Elucidating the biological risk factor in suicide: Role of protein kinase A. Prog Neuropsychopharmacol Biol Psychiatry (in press), 2011
Dwivedi Y. Brain-derived neurotrophic factor in suicide pathogenesis. Annals of Medicine 42(2):87-96, 2010
Dwivedi, Y., Rizavi HS, Zhang H, Roberts RC, Conley RR, Pandey GN. Modulation in activation and expression of PTEN, Akt, and PDK-1: evidence demonstrating altered phosphoinositide 3-kinase (PI 3-K) signaling in prefrontal cortex of suicide subjects. Biol. Psychiatry 1;67(11):1017-25, 2010
Dwivedi Y, Rizavi HS, Zhang H, Roberts RC, Conley RR, Pandey GN. Impaired extracellular signal-regulated kinase (ERK) kinase 1 (MEK 1) is central to the aberrant ERK 1/2 signaling in suicide brain. Int J. Neuropsychopharmacol 12(10):1337-54, 2009
Dwivedi Y, Rizavi H, Zhang H, Mondal A, Roberts RC, Conley RR, Pandey GN. Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. Biol. Psychiatry 65, 319-28, 2009
Dwivedi Y, Rizavi H, Teppen T, Zhang H, Mondal A, Roberts R, Conley R, Pandey G: Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory subunit isoforms in prefrontal cortex and hippocampus of suicide subjects. Neuropsychopharmacology 33, 2324-40, 2008
Donati RJ, Dwivedi Y, Roberts RC, Conley RR, Pandey GN, Rasenick MM Post-mortem brain tissue of depressed suicides reveals increased Gsa localization in lipid raft domains where it is less likely to activate adenylyl cyclase. J. Neuroscience 19;28:3042-50, 2008
Dwivedi Y, Rizavi H, Teppen T, Sasaki N, Chen H, Zhang H, Roberts R, Conley R, Pandey G: Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects. Neuropsychopharmacology, 32, 2338-50, 2007
Dwivedi Y, Mondal A, Rizavi HS, Faludi G, Palkovits M, Sarosi A, Conley RR. Pandey GN. Relevance of Rap-1 and Epac in aberrant cyclic AMP signaling in postmortem brain of depressed suicide subjects. Arch Gen Psychiatry 63, 639-648, 2006
Dwivedi Y, Rizavi HS, Pandey GN. Antidepressants reverse corticosterone-mediated decrease in BDNF expression: Dissociation in regulation of specific exons by antidepressants and corticosterone. Neuroscience 139, 1017-1029, 2006
Dwivedi Y, Mondal A, Rizavi HS, Conley RR. Pandey GN. ERK-MAP kinase signaling in postmortem brain of suicide subjects: Differential regulation of upstream Raf kinases, Raf-1 and B-Raf. Mol Psychiatry 11, 86-98, 2006
Yogesh Dwivedi, Ph.D.
Professor, Departments of Psychiatry and Pharmacology
Dr. Yogesh Dwivedi is an outstanding and well-known scientist with innovative ideas that have opened up important new areas of research in the field of depression and suicide. The major thrust of Dr. Dwivedi’s research is to elucidate the molecular and cellular mechanisms associated with depression, stress, and suicidal behavior by integrating basic and clinical neuroscience to comprehensively examine the roles of neurotrophins, apoptosis, and neural plasticity utilizing different approaches. He has hypothesized that abnormalities in cellular signaling that regulate cell survival/neural plasticity may serve as critical vulnerability factors that may predispose a person to suicidal/depressive behavior; such abnormalities may result from an abnormally functioning HPA axis and stress, both closely associated with suicidal/depressive behavior. Utilizing gene expression, microRNA, epigenetic, and gene knockout approaches, he has been identifying the abnormalities in signaling mechanisms, involved in synaptic/neural plasticity and cell survival. The model systems that he has been using include human postmortem brain, peripheral blood cells, animal models of depression and PTSD, and PKAR knockout mice. He has won numerous awards for his research and published more than 80 articles in peer-reviewed high-impact journals and several review articles and book chapters. His research is funded by National Institute of Mental Health, American Foundation for Suicide Prevention, NARSAD, Marshal Reynolds Foundation, and Stanley Foundation.
Interests:
Molecular neuroscience of affective disorders and suicide
Affiliations/Memberships:
American College of Neuropsychopharmacology, Society for Neuroscience, CINP, Society of Biological Psychiatry, International Neuropsychiatry Association, New York Academy of Sciences, American Society for Advancement of Sciences, International Society for Neurochemistry, American Society for Neurochemistry; Society of Experimental Biology and Medicine, International Society for Affective Disorders, International Association for Suicide Prevention; International Academy of Suicide Research, Task Force on Genetics and Neurobiology of Suicide
Projects:
- Role of calcium sensing proteins in depression
- Epigenetic studies in suicide brain
- microRNA studies in human brain
- Signal transduction mechanisms in suicide brain
- Role of apoptosis in depression: identification of altered activation and/or expression of critical – apoptotic proteins in postmortem brain of depressed subjects
- PI and Wnt signaling in postmortem brain of bipolar and schizophrenia subjects
- BDNF-Trk signaling, glucocorticoids and cytokines in patients with mood disorders
