Heide Klumpp, PhD

Heide Klumpp
Mood & Anxiety Disorders Research Program Department of Psychiatry
University of Illinois at Chicago
Room No. 246,
1747 W. Roosevelt Rd. (MC 747),
Chicago, IL 60608
Office Phone:312-996-0416
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Crane, N.A., Jenkins, L.M., Dion, C., Meyers, K.K., Weldon, A.L., Gabriel, L.B., Walker, S.J., Hsu, D.T., Noll, D.C., Klumpp, H., Phan, K.L., Zubieta, J-K., & Langenecker, S.A. (in press). Comorbid Anxiety Increases Cognitive Control Activation in Major Depressive Disorder. Depression and Anxiety.

Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., & Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine

Klumpp, H., Fitzgerald, D.A., Piejko, K., Roberts, J., Kennedy, A.E., Phan, K.L. (in press). Prefrontal control and predictors of cognitive behavioral therapy response in social anxiety disorder. Social Cognitive and Affective Neuroscience

Kujawa, A., Wu, M., Klumpp, H., Pine, D.S., Swain, J.E., Fitzgerald, K.D., Monk, C.S., Phan, K.L. (in press). Altered development of amygdala-frontal connectivity during emotional face processing in anxious youth and young adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Klumpp, H., Keutmann, M.K., Fitzgerald, D.A., Shankman, S.A., Phan, K.L. (2014). Resting state amygdala prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 4, 14

Wheaton, M.G., Fitzgerald, D.A., Phan, K.L., Klumpp, H. (2014). Perceptual load modulates anterior cingulate cortex response to threat distractors in generalized social anxiety disorder. Biological Psychology, 101, 13-7

Klumpp, H., Fitzgerald, D.A., Angstadt, M., Post, D., Phan, K.L. (2014). Neural response during attentional control and emotion processing predicts improvement after cognitive behavioral therapy in generalized social anxiety disorder. Psychological Medicine, 44, 3109-21

Klumpp, H., Fitzgerald, D.A., Phan, K.L. (2013). Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 45, 83-91

Klumpp, H., Fitzgerald, D.A., Cook, E., Shankman, S.A., Angstadt, M., Phan, K.L. (2014). Serotonin transporter gene alters insula activity to threat in social anxiety disorder. NeuroReport, 25, 926-931

Klumpp, H., Post, D., Angstadt, M., Fitzgerald, D.A., Phan, K.L. (2013). Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 3:7

Klumpp, H., Angstadt, M., Phan, K.L. (2012). Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological Psychology, 89, 273-276

Klumpp, H., Ho, S., Taylor, S.F., Phan, K.L., Abelson, J.L., Liberzon, I. (2011). Trait anxiety modulates anterior cingulate activation to threat interference. Depression and Anxiety, 28, 194-201

Heide Klumpp, PhD

Assistant Professor

Dr. Klumpp’s primary research interest is brain pathophysiology in anxiety and depression in the context of emotion, attention, and cognitive-affective processes for clinical translation.  She uses functional magnetic resonance imaging and electroencephalography to delineate brain markers of therapeutic response to psychotherapy to compare with other interventions to evaluate mechanisms of change and to translate discoveries from basic neuroscience into techniques to enhance therapies for internalizing disorders.  The overarching goal is to increase therapeutic response with available treatment and develop more individually-tailored, novel interventions. 


Brain mechanisms of emotion processing and regulation in anxiety and depression
Brain markers of treatment response in anxiety and depression
Information processing disturbances in internalizing disorders


Society of Biological Psychiatry
American Psychological Association
Anxiety and Depression Association of America


Brain Mechanisms of Cognitive Behavioral Therapy for Anxiety Disorders and Depression
Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
Sleep Disturbance in Mood Disorders Across the Lifespan


You are here: Home