University of Illinois at Chicago
Department of Psychiatry
912 S. Wood Street, (M/C 913)
Chicago, IL 60612
Office Phone: (312) 413-4572
Smalheiser, N.R., Lugli, G., Thimmapuram, J., Cook, E.H., & Larson, J., Endogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination training. RNA (in press).
Hu, Y.-S., Xu, P., Pigino, G., Brady, S.T., Larson, J., & Lazarov, O. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in Familial Alzheimer’s Disease-linked APPswe/PS1E9 mice. FASEB Journal, 24 (2010) 1667-1681.
Smalheiser, N.R., Lugli, G., Lenon, A., Davis, J.M., Torvik, V.I., & Larson, J. Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus. ASN Neuro, 2(1): e00028 (PMCID: PMC2832745).
Larson, J. & Park, T.J. Extreme hypoxia tolerance of naked mole-rat brain. NeuroReport, 20 (2009) 1634-1637 (PMID: 19907351).
Patel, R.C. & Larson, J. Impaired olfactory discrimination learning and decreased olfactory sensitivity in aged C57Bl/6 mice. Neurobiology of Aging, 30 (2009) 829-837 (PMID: 17904696).
Larson, J., Kim, D., Patel, R.C., & Floreani, C. Olfactory discrimination learning in mice lacking the fragile X mental retardation protein. Neurobiology of Learning and Memory, 90 (2008) 90-102 (PMCID: PMC2493566).
Lazarov, O. & Larson, J. Environmental enrichment: from mouse AD model to AD therapy. In: M.-K Sun (Ed.), Research Progress in Alzheimer’s Disease and Dementia (Vol. 3), New York: Nova (2008) pp. 303-328.
Larson, J. Jessen, R.E., Kim, D., Fine, A.-K.S., & J. du Hoffmann. Age-dependent and selective impairment of LTP in anterior piriform cortex of mice lacking the fragile X mental retardation protein. Journal of Neuroscience, 25 (2005) 9460-9469 (PMID: 16221856).
Larson, J. & Sieprawska, D. Automated study of simultaneous-cue olfactory discrimination learning in adult mice. Behavioral Neuroscience, 116 (2002) 588-599 (PMID: 12148926).
Larson, J., Lynch, G., Games, D., & Seubert, P. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Research, 840 (1999) 23-35 (PMID: 10517949).
John Larson, PhD
Associate Professor of Physiology in Psychiatry
Dr. Larson studies the cellular and molecular mechanisms of memory formation. Of primary interest is long-term potentiation (LTP), a form of synaptic plasticity thought to be responsible for memory storage in the mammalian forebrain. Research in the laboratory investigates the role of LTP in olfactory learning and memory in rodents with emphasis on mouse models of autism, mental retardation, and neurodegenerative diseases such as Alzheimer’s disease. Dr. Larson’s laboratory also studies neuronal specialization in the brains of naked mole-rats, in particular tolerance of brain neurons to extreme oxygen deprivation.
Cellular and molecular mechanisms for learning and memory; Olfaction (smell); Autism; Fragile X syndrome; Alzheimer’s disease; Comparative neurobiology
Cortical synaptic function and memory in mouse models for autism; Neurobiology of the naked mole-rat; Regulation of neuronal gene expression in learning; Synaptic plasticity and neuronal function in mouse models for Alzheimer’s disease; Olfactory learning and memory in mice. Aging and memory function in mice. Mechanisms for hypoxia tolerance in mammalian nervous system.