Neil R. Smalheiser, MD, PhD


University of Illinois at Chicago
Department of Psychiatry;
1601 West Taylor Street,
Rm 525,MC 912;
Chicago, IL, 60612

Office Phone: (312) 413-4581
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Smalheiser, N. R. (2007) Exosomal transfer of proteins and RNAs at synapses in the nervous system.  Biology Direct 2:35.

Smalheiser, N. R., Zhou, W. and Torvik, V. I. (2008) Anne O’Tate: A tool to support user-driven summarization, drill-down and browsing of PubMed search results. J. Biomed. Discovery Collab. 3:2.

Lugli, G., Torvik, V.I., Larson, J.R. and Smalheiser, N. R. (2008) Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain.  J. Neurochem 106: 650-661.

Smalheiser, N.R., Lugli, G., Torvik, V.I., Mise, N., Ikeda, R. and Abe, K. (2008) Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain. Neurosci. Res. 62: 236-239.

Smalheiser, N. R., Torvik, V.I. and Zhou, W. (2009) Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE. Comput. Meth. Programs Biomed. 94: 190-197.

Torvik, V. I. and Smalheiser, N. R. (2009) Author name disambiguation in MEDLINE. ACM Transactions on Knowledge Discovery from Data 3(3):11.  

Smalheiser, N. R. and Lugli, G. (2009) microRNA regulation of synaptic plasticity. NeuroMolecular Medicine 11: 133-140.

Smalheiser, N. R., Lugli, G., Lenon, A. L. Davis, J. M., Torvik, V. I. and Larson, J. R. (2010) Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus. ASN Neuro 2(1):art:e00028.

Smalheiser, N.R., Lugli G., Zhang, H., Rizavi, H. S., Torvik, V.I., Pandey, G.N., Davis, J. M. and Dwivedi, Y. (2010) microRNA expression in rat brain exposed to repeated inescapable shock: differential alterations in learned helplessness vs. non-learned helplessness. Int. J. Neuropsychopharmacol., in press.


Smalheiser, N. R., Lugli, G., Thimmapuram, J., Cook, E. H. and Larson, J. (2011) Endogenous siRNAs and noncoding RNA-derived small RNAs  are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination training. RNA 17: 166-181.



Neil R. Smalheiser, MD, PhD

Associate Professor in Psychiatry

Dr. Smalheiser has almost 30 years of experience pursuing basic wet-lab research in neuroscience, most recently studying synaptic plasticity and the genomics of small RNAs.  He has also directed multi-disciplinary, multi-institutional consortia dedicated to text mining and bioinformatics research, which have created new theoretical models, databases, open source software, and web-based services. Regardless of the subject matter, one common thread in his research is to link and synthesize different datasets, approaches and apparently disparate scientific problems to form new concepts and paradigms.  Another common thread is to identify scientific frontier areas that have fundamental and strategic importance, yet are currently under-studied, particularly because they fall “between the cracks” of existing disciplines.

Interests: neuroscience, RNA biology, synaptic plasticity, pathogenesis of neuropsychiatric disorders, medical informatics, text mining

Projects: http://arrowsmith.psych.uic.edu


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