www.psych.uic.edu

Articles

Chunyu Liu, Ph.D

cbatsha
CONTACT INFORMATION

900 S. Ashland Ave. Room 1006
Chicago, IL 60607

Office Phone: 312-413-2599
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

KEY PUBLICATIONS

1. Liu C*, Saffen D*, Schulze TG, Burmeister M, Sham PC, Yao YG, Kuo PH, Chen C, An Y, Chen L, Dai JP, Yue WH, Li MX, Xue H, Su B, Shi YY, Qiao MQ, Liu TB, Xia K, Shugart YY. Chan R. (2015) Psychiatric Genetics in China: achievements and challenges. Molecular Psychiatry. (In press)
2. Li J , Cai T, Jiang Y, Chen H, He X, Chen C , Li X, Shao Q, Ran X, Li Z, Xia X, Liu C*, Sun Z*, Wu J*. (2015) Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database. Mol Psychiatry (In press)
3. Liu C*, Chung M. Genetics and epigenetics of circadian rhythms and their potential roles in neuropsychiatric disorders. Neurosci Bull. 2015 Feb;31(1):141-59.
4. Chen C, Zhang C, Cheng L, Reilly J, Bishop J, Sweeney J, Chen H, Gershon ES, Liu C*. Correlation between DNA methylation and gene expression in the brains of bipolar and schizophrenia patients. Bipolar Disorders. 2014 (in press)1. Grennan, K. S., Chen, C., Gershon, E. S. and Liu, C*. (2014), Molecular network analysis enhances understanding of the biology of mental disorders. Bioessays, 36: 606–616.
5. Cheng L; Hattori E; Nakajima A; Woehrle N; Opal MD; Zhang C; Grennan K; Dulawa SC; Tang YP; Gershon ES; Liu C*. (2014) Expression of the G72/G30 gene in transgenic mice induces behavioral changes. Mol Psychiatry 19(2):175-83  PMCID: PMC3636154
6. Chen C, Cheng L, Grennan K, Pibiri F, Zhang C, Badner JA, Gershon ES, Liu C*. (2013) Two Gene Co-expression Modules Robustly Differentiate Psychotics and Controls. Mol Psychiatry 18(12):1308-14 PMCID: PMC3601550
7. Davis LK et al. Partitioning the Heritability of Tourette Syndrome (TS) and Obsessive Compulsive Disorder (OCD) Reveals Differences In Genetic Architecture. PLoS Genetics. 2013 Oct;9(10):e1003864. doi: 10.1371/journal.pgen.1003864. Epub 2013 Oct 24. PMCID: PMC3812053
8. Davis LK; Gamazon E; Kistner-Griffin E; Badner JA; Liu C; Cook EH; Sutcliffe JS; Cox NJ. (2012) Loci nominally  associated with autism from genome-wide analysis show enrichment of brain expressed quantitative trait loci (eQTL) but not lymphoblastoid cell line eQTLs. Molecular Autism. 3:3. PMCID: PMC3484025
9. Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, Gershon ES, Kelsoe JR, Greenwood TA, Nievergelt CM, Chen C, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Scheftner WA, Coryell W, Rice J, Lawson WB, Nwulia EA, Hipolito M, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zollner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Liu C* (2012): Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry . [Epub ahead of print] PMCID: PMC3601550
10. Gamazon ER, Badner JA, Cheng L, Zhang C, Zhang D, Cox NJ, Gershon ES, Kelsoe JR, Greenwood TA, Nievergelt CM, Chen C, McKinney R, Shilling PD, Schork NJ, Smith EN, Bloss CS, Nurnberger JI, Edenberg HJ, Foroud T, Koller DL, Scheftner WA, Coryell W, Rice J, Lawson WB, Nwulia EA, Hipolito M, Byerley W, McMahon FJ, Schulze TG, Berrettini WH, Potash JB, Zandi PP, Mahon PB, McInnis MG, Zollner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Liu C* (2012): Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry . [Epub ahead of print] PMCID: PMC3601550
11. Liu C (2011): Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases. Neuroscience Bulletin. 27(2):123-33.
12. Liu C*, Cheng L, Badner JA, Zhang D, Craig DW, Redman M, Gershon ES (2010): Whole-genome association mapping of gene expression in the human prefrontal cortex. Mol Psychiatry 15: 779-784. PMCID:PMC3057235
13. Zhang D, Cheng L, Badner JA, Chen C, Chen Q, Luo W, Craig DW, Redman M, Gershon ES, Liu C* (2010): Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 86: 411-419. PMCID:PMC2833385
14. Liu C*, Cheng L, Badner JA, Zhang D, Craig DW, Redman M, Gershon ES (2010): Whole-genome association mapping of gene expression in the human prefrontal cortex. Mol Psychiatry 15: 779-784. PMCID:PMC3057235
15. Zhang D, Cheng L, Badner JA, Chen C, Chen Q, Luo W, Craig DW, Redman M, Gershon ES, Liu C* (2010): Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 86: 411-419. PMCID:PMC2833385
16. Zhang D, Cheng L, Qian Y, Aliey-Rodriguez N, Kelsoe JR, Greenwood T, Nievergelt C, Barrett TB, McKinney R, Schork N, Smith EN, Bloss C, Nurnberger J, Edenberg HJ, Foroud T, Sheftner W, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze TG, Berrettini W, Potash JB, Belmonte PL, Zandi PP, McInnis MG, Zollner S, Craig D, Szelinger S, Koller D, Christian SL, Liu C*, Gershon ES* (2009): Singleton deletions throughout the genome increase risk of bipolar disorder. Mol Psychiatry 14: 376-380. PMCID: PMC2735188
17. Zhang R, Zhu Z, Zhu H, Nguyen T, Yao F, Xia K, Liang D, Liu C* (2005): SNP Cutter: a comprehensive tool for SNP PCR-RFLP assay design. Nucleic Acids Res 33: W489-W492.
18. Nguyen TH, Liu C, Gershon ES, McMahon FJ (2004): Frequency Finder: a multi-source web application for collection of public allele frequencies of SNP markers. Bioinformatics 20: 439-443.
19. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (2003): Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72: 1131-1140.
20. Liu C, Bonner TI, Nguyen T, Lyons JL, Christian SL, Gershon ES (2003): DNannotator: Annotation software tool kit for regional genomic sequences. Nucleic Acids Res 31: 3729-3735.
* as corresponding author

Chunyu Liu, Ph.D

Visiting Associate Professor

Dr. Liu has a long-term interest in understanding of molecular basis of psychiatric diseases. His laboratory participated one of the bipolar genetics research consortiums and discovered the rare copy number variant (CNV) burden in early-onset bipolar disorder. His lab is one of the leading research groups on genome-wide study of postmortem brain gene expression and DNA methylation, pioneered in study of gene expression regulatory network in human brain. He established the methylation quantitative trait loci (mQTLs) in human brain, indicating that DNA methylation of some sequences could be highly regulated by genetic variants. His research has been supported by NIMH, NARSAD, and Brain Research Foundation. He has published more than 80 peer-reviewed papers and several book chapters.

Interests:
Dr. Liu’s major research focuses on using a comprehensive approach that is composed of genetics, bioinformatics, genomics, and animal models to identify the molecular mechanisms of major psychiatric diseases, particularly bipolar disorder and schizophrenia. Constructing multidimensional regulatory network in human brains, and relating that to etiology and pathology of mental illness is the major mission of this lab.

Affiliations/Memberships:

American Society of Human Genetics
Society of Biological Psychiatry
International Society of Psychiatric Genetics


Projects:
  1. Gene expression regulatory network (GERN) in human brains and its relevance to mental illnesses;
  2. Functional genetic and epigenetic variants in human brains and associated psychiatric disorders;
  3. Bioinformatics: develop software/databases to support high-throughput data analysis and integration of multidimensional genomic / eipgenomic / genetic / phenotypic data.
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