www.psych.uic.edu

Current Research

Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
PI: K. Luan Phan, MD
R01MH101497 – National Institute of Mental Health

Internalizing psychopathologies (IPs) involving depression and anxiety are among the most prevalent, costly and disabling illnesses. Not everyone who gets treatment for depression and anxiety gets better. We do not know very much about how treatments work in the brain, or how differences in brain function may be used to guide the right patient to the right treatment with the highest likelihood of success. This study uses state-of-the-science approaches to study brain and behavior in patients with depression and/or anxiety in the context of medication treatment and psychotherapy to help us better understand how treatments work and for whom.

 

Determinants of Drug Preference in Humans
PI: K. Luan Phan, MD (UIC) & Harriet de Wit, PhD (University of Chicago)
2R01DA002812-32 – National Institute on Drug Abuse

Individuals differ in their risk for developing drug addiction, possibly because of neurobiological differences in the brain reward circuit. In this project we combine psychopharmacological and neuroimaging approaches to investigate individual differences in pleasurable effects of drugs, in relation to both the brain's response to reward, and the personality trait of extraversion. The studies will advance our understanding of the biological basis of substance abuse risk, and help to identify at-risk individuals.

 

Brain and Mental Health Recovery
PI: K. Luan Phan, MD
5I01CX000913 – VA Clinical Science Research and Development

Veterans with post-traumatic stress disorder (PTSD) exhibit brain dysfunction that could explain disturbances in how they perceive others around them and how they manage negative emotions and stress. Little is known if these patterns of brain dysfunction exist in soldiers returning from deployment in Afghanistan and Iraq who subsequently develop PTSD, or if and how the brain changes in those veterans whose PTSD persists and in those who recover from PTSD. The purpose of this study is to use a brain imaging technique that is non-invasive, inexpensive, easy-to-conduct, and portable to the outpatient clinical setting. The imaging will be used to study the brain processes involved in the processing of fear and in the regulation of negative emotions to evaluate how these brain processes change over the course of one year in relation to PTSD in OEF/OIF/OND veterans. This knowledge should improve our understanding and treatment of PTSD.

 

Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety Disorder
PI: Heide Klumpp, PhD
K23MH093679 – National Institute of Mental Health

Cognitive behavioral treatment (CBT) is a widely used first-line treatment for social anxiety disorder (SAD), a prevalent, debilitating disorder. Although many do not fully recover from SAD with CBT, the specific mechanisms by which CBT exerts its therapeutic effects are unknown. The primary goal of this research is to discover the effects of CBT on brain function, particularly in relation to specific emotion regulation strategies implicated in CBT-namely, increased attentional control over threat stimuli and higher-order cognitive regulation of emotions evoked by threat-relevant stimuli. A better understanding of the brain mechanisms of CBT and of individual differences in treatment response in patients with SAD will improve our understanding of CBT mechanisms thereby optimizing current therapies and contributing to the advancement of improved therapies to increase the probability of therapeutic success.

 

Brain-Behavior Markers of Negative Affectivity, Comorbidity in Anxiety Disorders
PI: Annmarie MacNamara, PhD
K23MH105553 – National Institute of Mental Health

Anxiety disorders (ADs) may be more similar than different in terms of neural dysfunction. For instance, comorbidity in the ADs is common and is known to relate to severity and measures of emotional reactivity such as self-reported negative affectivity (NA), yet evidence of its underlying neurobiology is scarce. The primary goal of this research is to test the utility of a dimensional transdiagnostic approach in linking neural and behavioral measures of dysregulated negative emotion processing to clinically relevant anxiety burden characterized by comorbidity load and self-reported NA. Comorbidity load, a marker of disease burden, may aid understanding of dimensional and categorical internalizing psychopathology.

External Collaborators

Emil Coccaro, MD
at the Department of Psychiatry and Behavioral Neurosciences at the University of Chicago

Michelle Craske, PhD
at the Department of Psychology at the University of California in Los Angeles

Harriet de Wit, PhD
at the Department of Psychiatry and Behavioral Neurosciences at the University of Chicago

Kate Fitzgerald, MD
at the Department of Psychiatry at the University of Michigan

Greg Hajcak, PhD
at the Department of Psychology at Stony Brook University

Kate Keenan, PhD
at the Department of Psychiatry and Behavioral Neurosciences at the University of Chicago

Andrea King, PhD
at the Department of Psychiatry and Behavioral Neurosciences at the University of Chicago

Benjamin Lahey, PhD
at the Department of Psychiatry and Behavioral Neurosciences at the University of Chicago

Israel Liberzon, MD
at the Department of Psychiatry at the University of Michigan

Stephen Maren, PhD
at the Department of Psychology at the Texas A&M University

Michael McCloskey, PhD
at the Department of Psychology of Temple University

Mohammed Milad, PhD
at the Department of Psychiatry at Massachusetts General Hospital and Harvard University

Christopher Monk, PhD
at the Department of Psychology at the University of Michigan

Pradeep Nathan, PhD
at the Department of Psychiatry at University of Cambridge

Christine Rabinak, PhD
at the Department of Pharmacy Practice at Wayne State University

Sheila Rauch, PhD
at the Department of Psychiatry at Emory University School of Medicine and the Mental Health Service at the Atlanta VA Medical Center

Murray Stein, MD, MPH
at the Department of Psychiatry and Family & Preventive Medicine at the University of California San Diego

Stephan Taylor, MD
at the Department of Psychiatry at the University of Michigan

Publications

See
For Phan KL: My Publications ncbi logo
For Klumpp H:My Publications ncbi logo

2016 & In Press

  • Gorka SM, MacNamara A, Aase, D., Proescher E, Greenstein J, Walters R, Passi H, Babione JM, Levy DL, Kennedy AE, DiGangi JA, Rabinak C, Schroth C, Afshar K, Fitzgerald J, Hajcak G & Phan KL (in press). Impact of alcohol use disorder comorbidity on defensive reactivity to errors in veterans with post-traumatic stress disorder. Psychology of Addictive Behaviors.
  • Kujawa A, Wu M, Swain JE, Fitzgerald KD, Monk CS, Phan KL (in press). Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults. Biological Psychiatry: Cognitive Neuroscience & Neuroimaging
  • Gorka SM, Fitzgerald DA, de Wit H, Phan KL (in press). Cannabinoid modulation of amygdala subregion functional connectivity to social signals of threat. International Journal of Neuropsychopharmacology
  • Bunford N, Kujawa A, Fitzgerald KD, Swain JE, Hanna GL, Koschmannn E, , Simpson D, Connolly S, , Monk CS, Phan KL (in press). Neural Reactivity to Angry Faces Predicts Treatment Response in Pediatric Anxiety. Journal of Abnormal Child Psychology
  • Bunford N, Kujawa A, Swain JE, Fitzgerald KD, Monk CS, Phan KL (in press). Attenuated Neural Reactivity to Happy Faces is Associated with Rule-Breaking and Social Problems in Anxious Youth. European Child & Adolescent Psychiatry
  • Crane NA, Jenkins LM, Dion C, Meyers, KK, Weldon AL, Gabriel LB, Walker SJ, Hsu DT, Noll DC, Klumpp H, Phan KL, Zubieta JK & Langenecker SA (in press). Comorbid Anxiety Increases Cognitive Control Activation in Major Depressive Disorder. Depression and Anxiety.
  • MacNamara A, Verges A, Kujawa A, Fitzgerald KD, Monk CS, Phan KL (2016). Age-related changes in emotional face processing across childhood and into young adulthood: evidence from event-related potentials. Developmental Psychobiology 58(1):27-38
  • Cremers H, Lee R, Keedy S, Phan KL, Coccaro EF (2016). Effects of Escitalopram Administration On Face Processing In Intermittent Explosive Disorder: an fMRI study. Neuropsychopharmacology 41(2):590-7
  • Fitzgerald J, MacNamara A, Rauch S, Kennedy A, Rabinak CA, Greenstein J, Proescher E, Hajcak G, and Phan KL (2016). An Electrocortical Investigation of Voluntary Emotion Regulation in Combat-Related Posttraumatic Stress Disorder. Psychiatry Research: Neuroimaging 249:113-21
  • MacNamara A, Rabinak CA, Kennedy A, Fitzgerald DA, Stein MB, Liberzon I, Phan KL (2016). Emotion regulatory brain function and SSRI treatment in PTSD: Neural correlates and predictors of change. Neuropsychopharmacology 41(2):611-8.
  • MacNamara A, Phan KL (2016). Psychobiological operationalization of RDoC constructs: Methodological and conceptual opportunities and challenges. Psychophysiology 53(3):406-9
  • DiGangi J, Tadayyon A, Fitzgerald DA, Rabinak CA, Kennedy A, Klumpp H, Rauch S, Phan KL (2016). Reduced Default Mode Network Connectivity Following Combat Trauma. Neuroscience Letters 615:37-43.
  • Gentili C, Cristea IA, Angstadt M, Klumpp H, Tozzi L, Phan KL, Pietrini P (2016). Beyond Emotions: A Meta-analysis of Neural Response Within Face Processing System in Social Anxiety. Experimental Biology and Medicine 241(3):225-37.
  • Coccaro EF, Fitzgerald DA, Lee R, McCloskey M, and Phan KL (2016). Fronto-Limbic Morphometric Abnormalities in Intermittent Explosive Disorder and Aggression. Biological Psychiatry: Cognitive Neuroscience & Neuroimaging 1:32–38
  • Evans GW, Swain JE, King AP, Wang X, Javanbakht A, Ho SS, Angstadt M, Phan KL, Xie H, Liberzon I (2016). Childhood Cumulative Risk Exposure and Adult Amygdala Volume and Function. J Neuroscience Research 94(6):535-43.
  • Gorka SM, Phan KL, Angstadt M, Mori S, Lysons M, Rabinak CA (2016). Cannabinoid modulation of frontolimbic activation and connectivity during volitional regulation of negative affect. Neuropsychopharmacology 41(7):1888-96.
  • Klumpp H, Fitzgerald DA, Piejko K, Roberts J, Kennedy A, Phan KL (2016). Prefrontal Control and Predictors of Cognitive Behavioral Therapy Response in Social Anxiety Disorder. Social Cognitive Affective Neuroscience 11(4):630-40
  • Kujawa A, Swain JE, Hanna GL, Koschmannn E, Simpson D, Connolly S, Fitzgerald KD, Monk CS, Phan KL (2016). Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth. Neuropsychopharmacology 41(8):1983-90.
  • MacNamara A, DiGangi J, Phan KL (2016). Aberrant Spontaneous and Task-Dependent Functional Connections in the Anxious Brain. Biological Psychiatry: Cognitive Neuroscience & Neuroimaging 1(3):278-287.
  • Jacobs RH, Barba, A, Gowins JR, Klumpp H, Jenkins L, Mickey BJ, Ajilore O, Pecina M, Sikora M, Ryan KA, Hsu DT, Welsh RC, Zubieta JK, Phan KL, & Langenecker SA (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine 46(5):1055-67
  • Burkhouse KL, Kujawa A, Kennedy AE, Shankman SA, Langenecker SA, Phan KL, Klumpp H (2016). Neural Reactivity to Reward as a Predictor of Cognitive Behavioral Therapy Response in Anxiety and Depression. Depression and Anxiety 33(4):281-8
  • Wu M, Kujawa A, Lu L, Fitzgerald DA, Fitzgerald KD, Monk CS, Phan KL (2016). Age-Related Changes in Amygdala-Frontal Connectivity during Emotional Face Processing from Childhood into Young Adulthood. Human Brain Mapping 37(5):1684-95.
  • Gorka SM, Lieberman L, Phan KL, & Shankman SA (2016). Association between problematic alcohol use and reactivity to uncertain threat in two independent samples. Drug and Alcohol Dependence 164:89-96.
  • McCloskey MS, Phan KL, Angstadt M, Fettich KC, Keedy S, Coccaro EF (2016). Amygdala Hyperactivation to Angry Faces in Intermittent Explosive Disorder. J Psychiatric Research 79:34-41.

2015

  • Gorka SM, Phan KL, Shankman SA (2015). Convergence of EEG and fMRI measures of reward anticipation. Biological Psychology 112:12-19.
  • Javanbakht A, King AP, Evans GW, Swain JE, Angstadt M, Phan KL, Liberzon I (2015). Childhood poverty predicts adult amygdala and frontal activity and connectivity in response to emotional faces. Frontiers in Behavioral Neuroscience 9:154.
  • Coccaro EF, Fanning JR, Phan KL, Lee R (2015). Serotonin and impulsive aggression. CNS Spectrums, 20(3): 295-302.
  • de Wit H, Gorka SM, Phan KL (2015). The Ups and Downs of MDMA: Linking Subjective Effects to Spontaneous Brain Function. Biological Psychiatry 78(8):519-21.
  • Tso I, Fang Y, Phan KL, Welsh RC, Taylor SF (2015). Abnormal GABAergic Function and Face Processing in Schizophrenia: A Pharmacologic-fMRI Study. Schizophrenia Research 168(1-2):338-44
  • Strawn JR, Hamm L, Fitzgerald DA, Fitzgerald KD, Monk CS, Phan KL (2015). Neurostructural abnormalities in pediatric anxiety disorders. Journal of Anxiety Disorders, 32:81-88.
  • Kujawa A, MacNamara A, Fitzgerald KD, Monk CS, Phan KL (2015). Enhanced neural reactivity to threatening faces in anxious youth: evidence from event related potentials. Journal of Abnormal Child Psychology, 43(8):1493-501.
  • MacNamara A, Rabinak CA, Fitzgerald DA, Zhou XJ, Shankman SA, Milad MR, Phan KL (2015). Neural correlates of individual differences in fear learning. Behavioral Brain Research 287:34-41.
  • Gorka SM, Fitzgerald DA, Labuschagne I, Hosanagar A, Wood AG, Nathan PJ, Phan KL (2015). Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder. Neuropsychopharmacology, 40(2):278-286.
  • Nelson BD, Fitzgerald DA, Klumpp H, Shankman SA, Phan KL (2015). Prefrontal engagement by cognitive reappraisal of negative faces. Behavioral Brain Research, 15;279:218-225.
  • Prossin AR, Zalcman SS, Heitzeg MM, Koch AE, Campbell PL, Phan KL, Stohler CS, Zubieta JK (2015). Dynamic interactions between plasma IL-1 family cytokines and central endogenous opioid neurotransmitter function in humans. Neuropsychopharmacology, 40(3):554-565.

2014

  • Klumpp H, Keutmann MK, Fitzgerald DA, Shankman SA, Phan KL (2014). Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 4:14.
  • Strawn JR, Dominick KC, Patino LR, Doyle CD, Picard LS, Phan KL (2014). Neurobiology of Pediatric Anxiety Disorders. Current behavioral neuroscience reports, 1(3):154-160.
  • Hamm LL, Jacobs RH, Johnson MW, Fitzgerald DA, Fitzgerald KD, Langenecker SA, Monk CS, Phan KL (2014). Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders. Biology of Mood & Anxiety Disorders, 4:15.
  • Sripada C, Angstadt M, Kessler D, Phan KL, Liberzon I, Evans GW, Welsh RC, Kim P, Swain JE (2014). Volitional regulation of emotions produces distributed alterations in connectivity between visual, attention control, and default networks. NeuroImage 89:110-121.
  • Klumpp H, Fitzgerald DA, Cook E, Shankman SA, Angstadt M, Phan KL (2014). Serotonin transporter gene alters insula activity to threat in social anxiety disorder. Neuroreport 25(12):926-931.
  • Klumpp H, Fitzgerald DA, Angstadt M, Post D, Phan KL (2014). Neural response during attentional control and emotion processing predicts improvement after cognitive behavioral therapy in generalized social anxiety disorder. Psychological Medicine. 44(14):3109-3121.
  • Jacobs RH, Jenkins LM, Gabriel LB, Barba A, Ryan KA, Weisenbach SL, Verges A, Baker AM, Peters AT, Crane NA, Gotlib IH, Zubieta JK, Phan KL, Langenecker SA, Welsh RC (2014). Increased Coupling of Intrinsic Networks in Remitted Depressed Youth Predicts Rumination and Cognitive Control. PLoS ONE 9(8):e104366.
  • Gorka SM, Nelson BD, Phan KL, Shankman SA (2014). Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression. Biology of Mood & Anxiety Disorders, 4:9.
  • Swartz JR, Phan KL, Angstadt M, Fitzgerald KD, Monk CS (2014). Dynamic changes in amygdala activation and functional connectivity in children and adolescents with anxiety disorders. Development and Psychopathology, 26(4 Pt 2):1305-1319.
  • Gorka SM, Fitzgerald DA, de Wit H, Angstadt M, Phan KL (2014). Opioid modulation of resting-state anterior cingulate cortex functional connectivity. Journal of Psychopharmacology 28(12), 1115-1124.
  • Clark-Elford R, Nathan PJ, Auyeung B, Voon V, Sule A, Müller U, Dudas R, Sahakian BJ, Phan KL, Baron-Cohen S (2014). The effects of oxytocin on social reward learning in humans. The International Journal of Neuropsychopharmacology 17(2):199-209.
  • Taylor SF, Demeter E, Phan KL, Tso IF, Welsh RC (2014). Abnormal GABAergic function and negative affect in schizophrenia. Neuropsychopharmacology 39(4):1000-1008.
  • Rabinak CA, Angstadt M, Lyons M, Mori S, Milad MR, Liberzon I, Phan KL (2014). Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans. Neurobiology of Learning and Memory, 113:125-134.
  • Rabinak CA, Phan KL (2014). Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment. Current Pharmaceutical Design 20(13), 2212-2217.
  • Swartz JR, Phan KL, Angstadt M, Klumpp H, Fitzgerald KD Monk CS (2014). Altered activation of the rostral anterior cingulate cortex in the context of emotional face distractors in children and adolescents with anxiety disorders. Depression and Anxiety, 31: 870–879.
  • Wheaton MG, Fitzgerald DA, Phan KL, Klumpp H (2014). Perceptual load modulates anterior cingulate cortex response to threat distractors in generalized social anxiety disorder. Biological Psychology. 101:13-17.
  • Gorka SM, Huggins AA, Fitzgerald DA, Nelson BD, Phan KL, Shankman SA (2014). Neural response to reward anticipation in those with depression with and without panic disorder. Journal of Affective Disorders, 164, 50–56.
  • Wardle MC, Fitzgerald DA, Angstadt M, Rabinak CA, de Wit H, Phan KL (2014). Effects of oxycodone on brain responses to emotional images. Psychopharmacology 231(22): 4403-4415.
  • Rabinak CA, MacNamara A, Kennedy AE, Angstadt M, Stein MB, Liberzon I, Phan KL (2014). Focal and aberrant prefrontal engagement during emotion regulation in veterans with posttraumatic stress disorder. Depression and Anxiety, 31: 851–861.
  • Shankman SA, Gorka SM, Nelson BD, Fitzgerald DA, Phan KL, O’Daly O (2014). Anterior insula responds to temporally unpredictable aversiveness: an fMRI study. Neuroreport, 25(8), 596–600.
  • Dodhia S, Hosanagar A, Fitzgerald DA, Labuschagne I, Wood AG, Nathan PJ, Phan KL (2014). Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder. Neuropsychopharmacology, 39(9), 2061–2069. 

2013

  • MacNamara A, Post D, Kennedy AE, Rabinak CA, Phan KL (2013). Electrocortical processing of social signals of threat in combat-related post-traumatic stress disorder. Biological Psychology, 94(2), 441–449.
  • Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS, Swain JE, Liberzon I, Phan KL (2013). Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. Proceedings of the National Academy of Sciences 110(46):18442-18447.
  • Fitzgerald KD, Liu Y, Stern ER, Welsh RC, Hanna GL, Monk CS, Phan KL, Taylor SF (2013). Reduced error-related activation of dorsolateral prefrontal cortex across pediatric anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry 52(11):1183-1191
  • Wheaton MG, Holman A, Rabinak CA, MacNamara A, Proudfit GH, Phan KL (2013). Danger and disease: electrocortical responses to threat- and disgust-eliciting images. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 90(2), 235–239.
  • Wardle MC, Fitzgerald DA, Angstadt M, Sripada CS, McCabe K, Phan KL (2013). The caudate signals bad reputation during trust decisions. PloS One, 8(6), e68884.
  • Sripada,CS, Kessler D, Welsh R, Angstadt M, Liberzon I, Phan KL, Scott C (2013). Distributed effects of methylphenidate on the network structure of the resting brain: a connectomic pattern classification analysis. NeuroImage, 81, 213–221.
  • Klumpp H, Fitzgerald DA, Phan KL (2013). Neural predictors and mechanisms of cognitive behavioral therapy on threat processing in social anxiety disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 45:83-91
  • Maren S, Phan KL, Liberzon I (2013). The contextual brain: implications for fear conditioning, extinction, and psychopathology. Nature Reviews Neuroscience 14(6):417-428
  • Sauder CL, Hajcak G, Angstadt M, Phan KL (2013). Test-retest reliability of amygdala response to emotional faces. Psychophysiology, 50(11), 1147–1156.
  • Gorka SM, Fitzgerald DA, King AC, Phan KL (2013). Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study. Psychopharmacology, 229(1), 141–154.
  • Das P, Coulston CM, Bargh DM, Tanious M, Phan KL, Calhoun VD, Malhi GS (2013). Neural antecedents of emotional disorders: a functional magnetic resonance imaging study of subsyndromal emotional symptoms in adolescent girls. Biological Psychiatry, 74(4), 265–272.
  • Malhi GS, Tanious M, Fritz K, Coulston CM, Bargh DM, Phan KL,Calhoun V, Das P (2013). Differential engagement of the fronto-limbic network during emotion processing distinguishes bipolar and borderline personality disorder. Molecular Psychiatry, 18(12), 1247–1248.
  • Klumpp H, Post D, Angstadt M, Fitzgerald DA, Phan KL (2013). Anterior cingulate cortex and insula response during indirect and direct processing of emotional faces in generalized social anxiety disorder. Biology of Mood & Anxiety Disorders, 3(1), 7.
  • Rabinak CA, Holman A, Angstadt M, Kennedy AE, Hajcak G, Phan KL (2013). Neural response to errors in combat-exposed returning veterans with and without post-traumatic stress disorder: a preliminary event-related potential study. Psychiatry Research, 213(1), 71–78.
  • Sripada CS, Angstadt M, Liberzon I, McCabe K, Phan KL (2013). Aberrant reward renter response to partner reputation during a social exchange game in generalized social phobia. Depression and Anxiety 30(4):353-61.
  • Strawn JR, Chu WJ, Whitsel RM, Weber WA, Norris MM, Adler CM, Eliassen JC, Phan KL, Strakowski SM, DelBello MP (2013). A pilot study of anterior cingulate cortex neurochemistry in adolescents with generalized anxiety disorder. Neuropsychobiology, 67(4), 224–229.
  • Phan KL, Coccaro EF, Angstadt M, Kreger KJ, Mayberg HS, Liberzon I, Stein MB (2013). Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia. Biological Psychiatry 73(4):329-36.
  • Prater KE, Hosanagar A, Klumpp H, Angstadt M, Phan KL (2013). Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder. Depression and Anxiety 30(3):234-41
  • Rabinak CA, Angstadt M, Sripada CS, Abelson JL, Liberzon I, Milad MR, Phan KL (2013). Cannabinoid facilitation of fear extinction memory recall in humans. Neuropharmacology, 64, 396–402.
  • Sripada CS, Phan KL, Labuschagne I, Welsh R, Nathan PJ, Wood AG (2013). Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex. The International Journal of Neuropsychopharmacology, 16(2), 255–260. 

2012

  • Klumpp H, Angstadt M, Phan KL (2012). Shifting the focus of attention modulates amygdala and anterior cingulate cortex reactivity to emotional faces. Neuroscience Letters, 514(2), 210–213.
  • Rabinak CA, Sripada CS, Angstadt M, de Wit H, Phan KL (2012). Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect. Journal of Neural Transmission 119(6), 701–707.
  • Klumpp H, Angstadt M, Phan KL (2012). Insula reactivity and connectivity to anterior cingulate cortex when processing threat in generalized social anxiety disorder. Biological Psychology, 89(1), 273–276. 

2011

  • Rabinak CA, Angstadt M, Welsh RC, Kennedy AE, Lyubkin M, Martis B, Phan KL (2011). Altered amygdala resting-state functional connectivity in post-traumatic stress disorder. Frontiers in Neuropsychiatric Imaging and Stimulation, 2, 62.
  • Labuschagne I, Phan KL, Wood A, Angstadt M, Chua P, Heinrichs M, Stout JC, Nathan PJ (2011). Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. The International Journal of Neuropsychopharmacology 15(7):883-896.
  • Sripada CS, Gonzalez R, Phan KL, Liberzon I (2011). The neural correlates of intertemporal decision-making: contributions of subjective value, stimulus type, and trait impulsivity. Human Brain Mapping 32(10):1637-1648.
  • Phan KL, Lee R, Coccaro EF (2011). Personality predictors of antiaggressive response to fluoxetine: inverse association with neuroticism and harm avoidance. International Clinical Psychopharmacology, 26(5), 278–283.
  • Rajarethinam R, Venkatesh BK, Peethala R, Phan KL, Keshavan M (2011). Reduced activation of superior temporal gyrus during auditory comprehension in young offspring of patients with schizophrenia. Schizophrenia Research, 130(1-3), 101–105.
  • Coccaro EF, Sripada CS, Yanowitch RN, Phan KL (2011). Corticolimbic function in impulsive aggressive behavior. Biological Psychiatry 69(12):1153-9.
  • Klumpp H, Ho SS, Taylor SF, Phan KL, Abelson JL, Liberzon I (2011). Trait anxiety modulates anterior cingulate activation to threat interference. Depression and Anxiety 28(3):194-201
  • Sripada CS, Angstadt M, McNamara P, King AC, Phan KL (2011). Effects of alcohol on brain responses to social signals of threat in humans. NeuroImage 55(1):371-80.
  • O’Neill, B.V., Croft, R.J., Mann, C., Dang, O., Leung, S., Galloway, M.P., Phan, K.L., Nathan, P.J. (2011). High-dose glycine impairs the prepulse inhibition measure of sensorimotor gating in humans. Journal of Psychopharmacology, 25(12), 1632–1638. 

2010

  • Phan KL, Sripada CS, Angstadt M, McCabe K (2010). Reputation for reciprocity engages the brain reward center. Proceedings of the National Academy of Sciences 107(29):13099-104.
  • Labuschagne I, Phan KL, Wood A, Angstadt M, Chua P, Heinrichs M, Stout JC, Nathan PJ (2010). Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 35(12):2403-13.
  • Klumpp H, Angstadt M, Nathan PJ, Phan KL (2010). Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: an event-related functional MRI study. Psychiatry Research: Neuroimaging 183(2): 167-169.
  • Oliva J, Leung S, Croft RJ, O’Neill BV, O’Kane J, Stout J, Phan KL, Nathan PJ (2010). The loudness dependence auditory evoked potential is insensitive to acute changes in serotonergic and noradrenergic neurotransmission. Human Psychopharmacology 25(5): 423-427.
  • Leung S, Croft RJ, Guille V, Scholes K, O’Neill BV, Phan KL, Nathan PJ (2010). Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants. Psychopharmacology 208(2):233-44.
  • King A, McNamara P, Angstadt M, Phan KL (2010). Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokers. Neuropsychopharmacology 35(3):692-701.
  • Labuschagne I, Croft RJ, Phan KL, Nathan PJ (2010). Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: an event related potential (ERP) investigation. Journal of Psychopharmacology 24(8):1153-64
  • Klumpp H, Keller J, Miller GA, Casas BR, Best JL, Deldin PJ (2010). Semantic processing of emotional words in depression and schizophrenia. Int J Psychophysiol. 75(2):211-5.
  • Klumpp H, Deldin P (2010). Review of brain functioning in depression for semantic processing and verbal fluency. Int J Psychophysiol. 2010 Feb;75(2):77-85

2009

  • Bedi G, Phan KL, Angstadt M, de Wit H (2009). Effects of MDMA on sociability and neural response to social threat and social reward. Psychopharmacology 207(1):73-83.
  • Sripada CS, Angstadt M, Banks S, Nathan PJ, Liberzon I, Phan KL (2009). Functional neuroimaging of mentalizing during the trust game in social anxiety disorder. Neuroreport, 20(11), 984–989.
  • Phan KL, Orlichenko A, Boyd E, Angstadt M, Coccaro EF, Liberzon I, Arfanakis K (2009). Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biological Psychiatry, 66(7), 691–694.
  • Shah SG, Klumpp H, Angstadt M, Nathan PJ, Phan KL (2009). Amygdala and insula response to emotional images in patients with generalized social anxiety disorder. Journal of Psychiatry & Neuroscience : JPN, 34(4), 296–302.
  • King AP, Abelson JL, Britton JC, Phan KL, Taylor SF, Liberzon I (2009). Medial prefrontal cortex and right insula activity predict plasma ACTH response to trauma recall. NeuroImage 47(3):872-80.
  • Kerestes R, Labuschagne I, Croft RJ, O’Neill BV, Bhagwagar Z, Phan KL, Nathan PJ (2009). Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study. Psychopharmacology 202(4):621-34.
  • Monteleone GT, Phan KL, Nusbaum HC, Fitzgerald D, Irick JS, Fienberg SE, Cacioppo JT (2009). Detection of deception using fMRI: better than chance, but well below perfection. Social Neuroscience 4(6):528-38.
  • Amir N, Beard C, Taylor CT, Klumpp H, Elias J, Burns M, Chen X (2009). Attention training in individuals with generalized social phobia: A randomized controlled trial. J Consult Clin Psychol 77(5):961-73.
  • Klumpp H, Amir N (2009). Examination of vigilance and disengagement of threat in social anxiety with a probe detection task. Anxiety Stress Coping 22(3):283-96.
  • Klumpp H, Amir N, Garfinkel SN. False memory and obsessive-compulsive symptoms.Depress Anxiety. 2009;26(5):396-402

2008

  • Pitroda S, Angstadt M, McCloskey MS, Coccaro EF, Phan KL (2008). Emotional experience modulates brain activity during fixation periods between tasks. Neuroscience Letters 443:72-76.
  • Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H (2008). Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. Journal of Neuroscience 28(10):2313-2319.
  • O’Neill BV, Guille V, Croft RJ, Leung S, Scholes KE, Phan KL, Nathan PJ (2008). Effects of selective and combined serotonin and dopamine depletion on the loudness dependence of the auditory evoked potential (LDAEP) in humans. Human Psychopharmacology, 23(4), 301–312.
  • Guille V, Croft RJ, O’Neill BV, Illic S, Phan KL, Nathan PJ (2008). An examination of acute changes in serotonergic neurotransmission using the loudness dependence measure of auditory cortex evoked activity: effects of citalopram, escitalopram and sertraline. Human Psychopharmacology 23:231-41.
  • Mann C, Croft RJ, Scholes KE, Dunne A, O’Neill BV, Leung S, Copolov D, Phan KL, Nathan PJ (2008). Differential effects of acute serotonin and dopamine depletion on prepulse inhibition and p50 suppression measures of sensorimotor and sensory gating in humans. Neuropsychopharmacology 33(7), 1653–1666.

2007

  • Banks SJ, Eddy KT, Angstadt M, Nathan PJ, Phan KL (2007). Amygdala-frontal connectivity during emotion regulation. Social Cognitive Affective Neuroscience 2: 303-312.
  • O’Neill BV, Croft RJ, Leung S, Oliver C, Phan KL, Nathan PJ (2007). High dose glycine inhibits the loudness dependence of the auditory evoked potentials (LDAEP) in healthy humans. Psychopharmacology 195(1):85-93.
  • Coccaro EF, McCloskey MS, Fitzgerald DA, Phan KL (2007). Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biological Psychiatry 62(2):168-78.
  • Scholes KE, Harrison BJ, O’Neill BV, Leung S, Croft RJ, Pipingas A, Phan KL, Nathan PJ (2007). Acute serotonin and dopamine depletion improves attentional control: findings from the stroop task. Neuropsychopharmacology 32(7):1600-10.
  • Liberzon I, King AP, Britton JC, Phan KL, Abelson JL, Taylor SF, (2007). Paralimbic and medial prefrontal cortical Involvement in neuroendocrine responses to traumatic stimuli. American Journal of Psychiatry 164:1250-8.
  • Liberzon I, Taylor SF, Phan KL, Britton JC, Fig LM, Bueller JA, Koeppe RA, Zubieta JK (2007). Altered central micro-opioid receptor binding after psychological trauma. Biological Psychiatry, 61(9), 1030–1038.
  • Yoon KL, Fitzgerald DA, Angstadt M, McCarron RA, Phan KL (2007). Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. Psychiatry Research, 154(1), 93–98. 

2006

  • Segrave R, Croft RJ, Illic S, Phan KL, Nathan PJ (2006). Pindolol does not augment central serotonin function increases to citalopram in humans: An auditory evoked potential investigation. Pharmacology, Biochemistry, and Behavior 85(1):82-90.
  • O’Neill BV, Croft RJ, Leung S, Guille V, Galloway M, Phan KL, Nathan PJ (2006). Dopamine receptor stimulation does not modulate the loudness dependence of the auditory evoked potential in humans. Psychopharmacology 188:92-9.
  • Britton JC, Phan KL, Taylor SF, Welsh RC, Berridge KC, Liberzon I (2006). Neural correlates of social and nonsocial emotions: An fMRI Study. Neuroimage 31:397-409.
  • Fitzgerald DA, Angstadt M, Jelsone LM, Nathan PJ, Phan KL (2006). Beyond threat: Amygdala reactivity across multiple expressions of facial affect. Neuroimage 30:1441-1448.
  • Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006). Association between amygdala hyperactivity to harsh faces and severity of social anxiety symptoms in generalized social phobia. Biological Psychiatry 59:424-429.
  • Nathan PJ, Segrave R, Phan KL, O’Neill B, Croft RJ (2006). Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function. Human Psychopharmacology 21:47-52.
  • Phan KL, Britton JC, Taylor SF, Fig LM, Liberzon I (2006). Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry, 63(2), 184–192. 

2005

  • Cortese BM, Phan KL (2005). The role of glutamate in anxiety and related disorders. CNS Spectrums 10(10):820-830.
  • Green A, Ellis KA, Ellis J, Barthomomeusz CF, Ilic S, Croft RJ, Phan KL, Nathan PJ (2005). Muscarinic and nicotinic receptor modulation of object and spatial n-back working memory in humans. Pharmacology, Biochemistry, and Behavior 81(3):575-584.
  • Taylor SF, Phan KL, Britton JC, Liberzon I (2005). Neural response to emotional salience in schizophrenia. Neuropsychopharmacology 30(5):984-995.
  • Britton JC, Phan KL, Taylor SF, Fig LM, Liberzon I (2005). Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery. Biological Psychiatry, 57(8), 832–840.
  • McCloskey MS, Phan KL, Coccaro EF (2005). Neuroimaging and personality disorders. Current Psychiatry Reports 7(1):65-72.
  • Phan KL, Magalhaes A, Ziemlewicz TJ, Fitzgerald DA, Green C, Smith W (2005). Neural correlates of telling lies: a functional magnetic resonance imaging study at 4 Tesla. Academic Radiology, 12(2), 164–172.
  • Phan KL, Fitzgerald DA, Cortese BM, Seraji-Bozgorzad N, Tancer ME, Moore GJ (2005). Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4 Tesla. Neuroreport 16(2):183-186.
  • Phan KL, Fitzgerald DA, Nathan PJ, Moore GJ, Uhde TW, Tancer ME (2005). Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance study. Biological Psychiatry 57(3):210-219.
  • Teter CJ, Phan KL, Cameron OG, Guthrie SK (2005). Relative rectal bioavailability of fluoxetine in normal volunteers. Journal of Clinical Psychopharmacology 25(1):74-78.
  • Amir N, Klumpp H, Elias J, Bedwell JS, Yanasak N, Miller LS (2005). Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. Biol Psychiatry. 57(9):975-81.

2004

  • Fitzgerald DA, Posse S, Moore GJ, Tancer ME, Nathan PJ, Phan KL (2004). Neural correlates of internally-generated disgust via autobiographical recall: A functional magnetic resonance imaging investigation. Neuroscience Letters 370:91-96.
  • Erskine FF, Elllis JR, Ellis KA, Stuber E, Hogan K, Miller V, Moore E, Bartholomeusz C, Harrison BJ, Lee B, Phan KL, Liley DT, Nathan PJ (2004). Evidence for synergistic modulation of early information processing by nicotinic and muscarinic receptors in humans. Human Psychopharmacology 19:503-509.
  • Lu K, Gray MA, Oliver C, Liley DT, Harrison BJ, Bartholomeusz CF, Phan KL, Nathan PJ (2004). The acute effects of L-theanine in comparison to alprazolam on anticipatory anxiety in humans. Humam Psychopharmacology 19:457-465.
  • Hayasaka S, Phan KL, Liberzon I, Worsley KJ, Nichols TE (2004). Non-stationary cluster size inference with random field and permutation methods. NeuroImage 22(2):676-687.
  • Phan KL, Wager TD, Taylor SF, Liberzon I (2004). Functional neuroimaging studies of human emotions. CNS Spectrums, 9(4), 258–266.
  • Taylor SF, Welsh RC, Wager TD, Phan KL, Fitzgerald KD, Gehring WJ (2004). A functional neuroimaging study of motivation and executive function. NeuroImage 21:1045-1054.
  • Phan KL, Fitzgerald DA, Gao K, Moore GJ, Tancer ME, Posse S (2004). Real-time fMRI of cortico-limbic brain activity during emotional processing. NeuroReport 15:527-532.
  • Phan KL, Taylor SF, Welsh RC, Ho SH, Britton JC, Liberzon I (2004). Neural correlates of individual ratings of emotional salience: a trial-related fMRI study. NeuroImage, 21(2), 768–780. 

2003

  • Liberzon I, Britton JC, Phan KL (2003). Neural correlates of traumatic recall in posttraumatic stress disorder. Stress 6:151-156.
  • Liberzon I, Phan KL (2003). Brain imaging studies of posttraumatic stress disorder. CNS Spectrums 8:625-634.
  • Liberzon I, Phan KL, Khan S, Abelson JL (2003). Role of GABA-A receptors in anxiety: Evidence from animal models, clinical psychopharmacology, and neuroimaging studies. Current Neuropharmacology 1:267-283.
  • Wager TD, Phan KL, Liberzon I, Taylor SF (2003). Valence, gender, and lateralization of functional brain anatomy in emotion: A meta-analysis of findings from neuroimaging. NeuroImage 19:513-531.
  • Liberzon I, Phan KL, Decker LR, Taylor SF (2003). Extended amygdala and emotional salience: A PET investigation of positive and negative affect. Neuropsychopharmacology 28:726-733.
  • Phan KL, Liberzon I, Welsh RC, Britton JC, Taylor SF (2003). Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures. Neuropsychopharmacology 28:1344-1350.
  • Taylor SF, Phan KL, Decker LR, Liberzon I (2003). Subjective rating of emotionally salient stimuli modulates limbic activity. NeuroImage 18:650-659.
  • Phan KL, Taylor SF, Welsh RC, Decker LR, Noll DC, Nichols TE, Britton JC, Liberzon I (2003). Activation of the medial prefrontal cortex and extended amygdala by individual ratings of emotional arousal: a fMRI study. Biological Psychiatry 53:211-215.
  • Amir N, Elias J, Klumpp H, Przeworski A (2003). Attentional bias to threat in social phobia: facilitated processing of threat or difficulty disengaging attention from threat? Behav Res Ther. 41(11):1325-35.

2002

  • Phan KL, Wager TD, Taylor SF, Liberzon, I (2002). Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. NeuroImage 16:331-348.
  • Liberzon I, Zubieta JK, Fig LM, Phan KL, Koeppe RA, Taylor SF (2002). mu-Opiod receptors and limbic responses to aversive emotional stimuli. Proceedings of the National Academy of Sciences of the Unites States of America (PNAS) 99:7084-7089.
  • Phan KL, Taylor SF (2002). Clozapine-associated cardiomyopathy. Psychosomatics 43(3):248. 

2000

  • Phan KLD, Aldridge AM (2000). Clinical case presentation: delusional depression in an elderly patient. Journal of Practical Psychiatry, 1:52-54.
  • van Dyck CH, Malison RT, Seibyl JP, Laruelle M, Klumpp H, Zoghbi SS, Baldwin RM, Innis RB (2000). Age-related decline in central serotonin transporter availability with [(123)I]beta-CIT SPECT. Neurobiol Aging 21(4):497-501.

1999

  • Fetters MD, Doukas DJ, Phan KL (1999). Family physicians’ perspectives on genetics and the human genome project. Clinical Genetics, 56:28-34, 1999. 

1995

  • Phan KL, Doukas DJ, Fetters MD (1995). Religious leaders’ attitudes and beliefs about genetics research and the Human Genome Project. Journal of Clinical Ethics, 6:237-246. 

Active Projects

Brain Mechanisms of Cognitive Behavioral Therapy for Social Anxiety
National Institute of Mental Health, K23MH093679 

Cognitive, Clinical and Neural Markers of Late Life Depression
Veterans Affairs Career Development Program, CDA-2: D7494W 

Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment
National Institute of Mental Health, 1R01MH101497

Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents
National Institute of Mental Health, 1R01MH086517 

Cannabinoid Control of Fear Extinction Neural Circuits in Humans
National Institute of Mental Health, R21MH093917 

Brain and Mental Health RECOVERY
Veterans Affairs Merit Review Program 

Neurofunctional Markers of SSRI Response in PTSD
Veterans Affairs Merit Review Program 

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