Dr. Smalheiser is a neuroscientist with 20 years of experience in biochemical, molecular, developmental, and cellular studies of nerve cells. He is one of the pioneers in the study of small RNAs and RNA interference in the nervous system. He is also an international leader in the development of new data-mining techniques in medical informatics and bioinformatics.

Representative publications

Smalheiser, N. R. and Kim, E. (1995) Purification of cranin, a laminin binding protein. Identity to dystroglycan and reassessment of its carbohydrate moities. J. Biol. Chem. 270: 15425-15433.

Smalheiser, N. R. (1996) Proteins in unexpected locations. Molec. Biol. Cell 7: 1003-1014.

Swanson, D. R. and Smalheiser, N. R. (1997) An interactive system for finding complementary literatures: a stimulus to scientific discovery. Artif. Intell. 91: 183-203.

Smalheiser, N. R., Costa, E., Guidotti, A., Impagnatiello, F., Auta, J., Lacor, P., Kriho, V. and Pappas, G. (2000) Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia and adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA 97: 1281-1286.

Manev, H., Uz, T., Smalheiser, N. R. and Manev, R. (2001) Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. Eur. J. Pharmacol. 411: 67-70.

Smalheiser, N. R., Manev, H. and Costa, E. (2001) RNAi and Memory: Was McConnell on the right track after all? Trends in Neurosci. 24: 216-218.

Das, A., Smalheiser, N. R., Markaryan, A. and Kaplan, A. (2002) Evidence for binding of the ectodomain of amyloid precursor protein 695 and activated high molecular weight kininogen.Biochimica et Biophysica Acta (General Subjects) 1571: 225-238.

Lugli, G., Krueger, J. M., Davis, J.M. Persico, A. M., Keller, F. and Smalheiser, N. R. (2003) Methodological factors influencing measurement and processing of plasma reelin in humans. BMC Biochemistry 4: 9. http://www.biomedcentral.com/1471-2091/4/9

Torvik, V. I., Weeber, M., Swanson, D. R. and Smalheiser, N. R. (2003) A probabilistic similarity metric for Medline records: a model for author name disambiguation. J. Am. Soc. Information Sci. Technol, in press.

Smalheiser, N. R. and Torvik, V. I. (2004) A Population-based Statistical Approach Identifies Parameters Characteristic of Human microRNA-mRNA Interactions. BMC Bioinformatics 5:139.