Dr. Manev's clinical and research interests are depression and anxiety disorders, and the adult ADHD. She is investigating a putative role for 5-lipoxygenase, typically considered an inflammatory enzyme, in psychiatric disorders.

Representative Publications

Manev R, Manev H. 5-Lipoxygenase as a putative mechanism of NSAID-related psychiatric adverse events. Drugs 65(4):577, 2005.

Manev H, Manev R: 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease, Med Hypotheses, 66(3): 501-503, 2006.

Manev R., Manev H. : 5-Lipoxygenase as a putative link between cardiovascular and psychiatric disorders. Crit. Reviews Neurobiol., 16:177-82, 2004.

Yildirim E., Zhang Z., Uz T., Chen C.-Q., Manev R., Manev H.: Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus, Neurosci. Lett., 345: 141-143, 2003.

Manev R., Manev H.: The meaning of mammalian adult neurogenesis and the function of newly added neurons: the “small world” network. Med. Hypotheses, 64:114-117, 2005.

Manev H., Uz T., Neil R. Smalheiser, Manev R.: Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro, Eur. J. Pharmacol., 411: 67-70, 2001.

Manev H, Manev R: Nomen est Omen: do antidepressants increase p11 or S100A10? J Biomed Discov Collaboration, 1:5, 2006.

Akhisaroglu M., Manev R., Akhisaroglu E., Uz T., Manev H.: Both aging and fluoxetine increase S100B content in the mouse hippocampus. NeuroReport, 14: 1471-1473, 2003.

Manev H., Uz T., Manev R.: Glia as a putative target for antidepressant treatments. J. Affect. Disord., 75: 59-64, 2003.

Manev R., Uz T., Manev H. Fluoxetine increases the content of neurotrophic protein S100B in the rat hippocampus. Eur. J. Pharmacol., 420: R1-R2, 2001.

Manev R., Manev H.: Aminoglycoside antibiotics and autism: a speculative hypothesis. BMC Psychiatry, 1: 5, 2001.