Dr. Manev is an internationally renowned neuroscientist who has made important contributions to research in the fields of neuroprotection and molecular mechanisms of action of psychoactive drugs. Currently, his laboratory develops animal models, including fruit flies, for studies of molecular mechanisms and novel concepts important for mood disorders and drugs of abuse. Dr. Manev serves on numerous committees, including the NIH study section CNNT, on editorial boards of several journals, including Restorative Neurology and Neuroscience, and he has published over 160 peer-reviewed articles.

Representative Publications

Manev H, Manev R: Nomen est Omen: do antidepressants increase p11 or S100A10? J Biomed Discov Collaboration, 1:5, 2006.

Larson J, Jessen RE, Uz T, Arslan AD, Kurtuncu M, Imbesi M, Manev H: Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice. Neurosci Lett, 393: 23-26, 2006.

Manev H, Uz T: Clock genes: influencing and being influenced by psychoactive drugs. Trends Pharmacol Sci, 27(4):186-189, 2006.

Uz T, Ahmed R, Akhisaroglu M, Kurtuncu M, Imbesi M, Arslan AD, Manev H: Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Neuroscience, 134: 1309-1316, 2005.

Zhang Z., Chen C., Manev H.: An improved enzymatic regional methylation assay for determination of CpG methylation density. Anal. Chem., 76:6829-6832, 2004.

Zhang Z., Chen C., Manev H.: DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells. J. Neurochem., 88(6):1424-1430, 2004.

Uz T., Akhisaroglu M., Ahmed R., Manev H.: The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice, Neuropsychopharmacology, 28:149-152, 2003.

Manev H., Uz T., Neil R. Smalheiser, Manev R.: Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro, Eur. J. Pharmacol., 411: 67-70, 2001.

Dzitoyeva S., Dimitrijevic N., Manev H.: GABABR1 receptors mediate behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence, Proc. Natl. Acad. Sci. USA, 100: 5485-5490, 2003.

Dzitoyeva S., Dimitrijevic N., Manev H.: Intra-abdominal injection of double-stranded RNA into anesthetized adult Drosophila triggers RNA interference (RNAi) in the central nervous system. Mol. Psychiatry, 6: 665-670, 2001.