Dr. Manev is an internationally renowned neuroscientist who has made important contributions to research in the fields of neuroprotection and molecular mechanisms of action of psychoactive drugs. Currently, his laboratory studies molecular mechanisms and novel concepts important for brain aging, mood disorders, and addiction. Dr. Manev serves on numerous committees and editorial boards of several journals and he has published over 170 peer-reviewed articles.

Representative Publications

Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST: Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease. J Histochem Cytochem. 2008 Aug 4. [Epub ahead of print]

Uz T, Dwivedi Y, Pandey GN, Roberts RC, Conley RR, Manev R, Manev H: 5-Lipoxygenase in the prefrontal cortex of suicide victims. Open Neuropsychopharmacol J, 1: 1-5, 2008.

Manev H, Manev R, Vidovich MI: Depression, inflammation, and cardiovascular disease: is 5-lipoxygenase the missing link? J Am Coll Cardiol. 51(20):1990-1, 2008.

Imbesi M, Uz T, Manev R, Sharma RP, Manev H. Minocycline increases phosphorylation and membrane insertion of neuronal GluR1 receptors. Neurosci Lett. 2008 Dec 12;447(2-3):134-7.

Imbesi M, Zavoreo I, Uz T, Sharma RP, Dimitrijevic N, Manev H, Manev R: 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo. Brain Res. 1147:148-53, 2007.

Manev H, Uz T: Clock genes: influencing and being influenced by psychoactive drugs. Trends Pharmacol Sci, 27(4):186-189, 2006.

Uz T, Ahmed R, Akhisaroglu M, Kurtuncu M, Imbesi M, Arslan AD, Manev H: Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Neuroscience, 134: 1309-1316, 2005.

Zhang Z., Chen C., Manev H.: DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells. J. Neurochem., 88(6):1424-1430, 2004.

Manev H., Uz T., Neil R. Smalheiser, Manev R.: Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro, Eur. J. Pharmacol., 411: 67-70, 2001.

Joo JY, Uz T, Manev H: Opposite effects of pinealectomy and melatonin administration on brain damage following cerebral focal ischemia in rat. Restor Neurol Neurosci. 13:185-91, 1998.