Research Interests: Neurosteroids and depression, Reelin in schizophrenia, cocaine reinforcement pharmacology

Representative Publications

Hankiewicz JH, Brint SU, Guidotti A, Costa E, Fiat D (2003) In vivo abundance of 17O/1H MRI of Rhesus monkey in a whole body scanner. Appl Magn Reson 24:423-427.

Costa E, Grayson DR, Mitchell CP, Tremolizzo L, Veldić M, Guidotti A (2003) Cortical GABAergic neuron chromatin as a putative target to treat schizophrenia symptomomatology. Crit Rev Neurobiol 15, 121-142, 2003.

Veldić M, Caruncho HM, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E (2004) DNA methyltransferase-1 (DNMT1) is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. PNAS USA 101:348-353

Costa E, Grayson DR, Guidotti A (2004) Neurochemical basis for an epigenetic vision of synaptic organization. In Smythies J (Ed) Disorders of Synaptic Plasticity, International Review of Neurobiology Vol 59, pp73-91, Elsevier, San Diego.

Pinna G, Costa E, Guidotti A. (2004) Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proc Natl Acad Sci USA 101:6222-6225.

Auta J, Costa E, Davis, J, Guidotti A (2004) Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Neuropharmacology 46:397-403.

Carboni G, Tueting P, Tremolizzo L, Sugaya I, David J, Costa E, Guidotti A (2004) Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation. Neuropsychopharmacology, 46:1070-1081.

Cagetti E, Pinna G, Guidotti A, Baicy K, Olsen RW (2004) Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus accompanied by altered behavioral responses to neurosteroids and memory function. Neuropharmacology 46:570-579.

Pinna G, Agis-Balboa RC, Doueiri M-S, Guidotti A, Costa E (2004) Brain neurosteroids in gender-related aggression induced by social isolation. Crit Rev Neurobiol 16:75-82.

Costa E, Guidotti A, Veldić M (2004) Should allosteric positive modulators of GABAA receptors be tested in the treatment of schizophrenia? Schiz Res (Letters to the Editors) (In Press, Corrected Proof, Available online 19 September 2004)

Costa E, Davis JM, Dong E, Grayson DR, Guidotti A, Tremolizzo L, Veldić M (2004) A GABAergic cortical deficit dominates schizophrenia pathophysiology. Crit Rev Neurobiol 16:1-24.

Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Pinna G, Tueting P, Rodriguez-Menendez V, Costa E, Guidotti A (2004) Valproate corrects a methionine-induced schizophrenia neuropathology in mouse. Biol Psychiatry, submitted.

Guidotti A, Auta J. Davis JM, Dong E, Grayson DR, Veldić M, Zhang X, Costa E (2004) GABAergic dysfunction in schizophrenia: a new treatment target on the horizon. Psychopharmacology (submitted)

Noh JS, Sharma RP, Veldić M, Salvaćion AA, Jia, X, Chen Y, Costa, E, Guidotti, A, Grayson, R. DNA methyltransferase 1 regulates reelin mRNA expression in primary mouse cortical cultures. Proc Natl Acad Sci (submitted)

Mitchell CP, Chen Y, Costa E, Grayson DR (2004) Studies on epigenetic mechanisms regulating the human reelin promoter: implications for the treatment of schizophrenia. (in preparation).