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Dr. Yogesh Dwivedi is an outstanding and well-known young scientist with innovative ideas that have opened up important new areas of research. He already has a number of seminal findings to his credit published in peer-reviewed highly reputed journals. The major thrust of Dr. Dwivedi’s research is to elucidate the molecular and cellular mechanisms associated with depression and suicidal behavior by comprehensively examining the roles of signal transduction mechanisms and their regulation by the HPA axis. His recently proposed hypothesis that abnormalities in cell survival pathways may lead to abnormalities in brain structure and thus to depressive and suicidal behavior has aroused widespread interest and attention. Utilizing postmortem brain, peripheral blood cell, and animal studies, he has identified abnormalities in signaling mechanisms, in particular, in various kinases, phosphatases, substrate molecules, and growth factors, involved in brain function and cell survival, which may serve as vulnerability factors in depression and suicide. His studies have clarified the dysfunctional signaling in these disorders and could lead to a fundamental breakthrough in understanding of the neurobiology of depression and suicide, which has a devastating impact on numerous lives, and may eventually help in designing better and more appropriate treatment strategies. Dr. Dwivedi has successfully integrated basic and clinical neuroscience by studying signaling systems and psychoactive drugs in human postmortem brain, in peripheral blood cells of suicidal/depressed patients, and using animal studies, and has developed an original animal model of depression and PTSD. He has won numerous awards for his research and is funded by the NIMH. His expertise is now sought for collaborative studies, as an invited speaker, as an author of book chapters and reviews, and as a reviewer of numerous journals and reviewer to NIMH Extramural Research Branch.
Representative Publications
Y. Dwivedi, H. Rizavi, T. Teppen, N. Sasaki, H. Chen, H. Zhang, R. Roberts, R. Conley, G. Pandey: Aberrant Extracellular Signal-Regulated Kinase (ERK) 5 Signaling in Hippocampus of Suicide Subjects. Neuropsychopharmacology (in press), 2007
Y. Dwivedi, A. Mondal, H. Rizavi, G. Faludi, M. Palkovits, A. Sarosi, R.R. Conley, G.N. Pandey: Relevance of Rap-1 and Epac in aberrant cyclic AMP signaling in postmortem brain of depressed suicide subjects. Arch. Gen Psychiatry 63, 639-648, 2006
Y. Dwivedi, H. Rizavi, Pandey GN: Antidepressants reverse corticosterone-mediated decrease in BDNF expression: Dissociation in regulation of specific exons by antidepressants and corticosterone. Neuroscience 139, 1017-1029, 2006
Y. Dwivedi, A. Mondal, H. Rizavi, R.R. Conley, G.N. Pandey: ERK-MAP kinase signaling in postmortem brain of suicide subjects: Differential regulation of upstream Raf kinases, Raf-1 and B-Raf. Mol. Psychiatry 11, 86-98, 2006
H Chen, GN Pandey, Y Dwivedi: Hippocampal cell proliferation regulation by repeated stress and antidepressants. Neuroreport Jun 26;17(9):863-7, 2006
Y. Dwivedi, A. Mondal, H. Rizavi R.R. Conley: Suicide brain is associated with decreased expression of neurotrophins. Biological Psychiatry 58, 315-324, 2005
Y. Dwivedi, A. Mondal, H. Rizavi, P. Shukla, G. Pandey: Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in learned helpless behavior. Neuropsychopharmacology 30:473-483, 2005
Y. Dwivedi, A. Mondal, H. Rizavi: Differential regulation of serotonin (5HT)2A receptor mRNA and protein levels after single and repeated stress in rat brain: role in learned helplessness behavior. Neuropharmacology 48:204-214, 2005
Y. Dwivedi, H. Rizavi, P. Shukla, J. Lyons, G. Faludi, M. Palkovits, A. Sarosi, R.R. Conley, R.C. Roberts, C.A. Tamminga, G.N. Pandey: PKA in postmortem brain of depressed suicide victims: Altered expression of specific regulatory and catalytic subunits. Biological Psychiatry 55: 234-243, 2004
Y. Dwivedi, H. Rizavi, R.R. Conley, R.C. Roberts, C.A. Tamminga, G.N. Pandey: Alterations in gene expression of BDNF and TrkB in postmortem brain of suicide victims. Arch Gen Psychiatry, 60, 804-815, 2003
Y. Dwivedi, J. SridharaRao, H. Rizavi, J. Kotowaski, R.R. Conley, R.C. Roberts, C.A. Tamminga, G.N. Pandey: Abnormal expression and functional characteristics of cyclic AMP response element binding protein in postmortem brain of suicide subjects. Arch Gen Psychiatry 60, 273-282, 2003
Y. Dwivedi, R.R. Conley, R.C. Roberts, C.A. Tamminga, G.N. Pandey: [3H]CyclicAMP binding sites and PKA activity in the prefrontal cortex of suicide victims. Am J Psychiatry 159:66-73, 2002
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