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Clinical
Profile of an Atypical Antipsychotic: Risperidone
John
A. Davis and Nancy Chen
Schematic
for the haloperidol-responsive, haloperidol-nonresponsive,
serotonin-sensitive,
and dopamine-sensitive scales
|
Scale
|
Criteria
|
| Haloperidol-responsive |
Haloperidol
better than Placebo, p < 0.05 |
| Haloperidol-nonresponsive |
All
others |
|
|
| Dopamine-sensitive* |
Haloperidol
better than Placebo, p < 0.01 |
| Serotonin-sensitive* |
Risperidone
6-16 mg better than Haloperidol, p< 0.01 |
* On PANSS item
7 (hostility) the haloperidol-placebo and risperidone-haloperidol differences
were both statistically significant. We therefore calculated the respective
size effects of the difference: mean improvement on haloperidol (or
risperidone) minus mean improvement on placebo (or haloperidol) over
the pooled standard deviation. In both the dopamine-sensitive and the
serotonin-sensitive scales, the effect sizes were approximately equal
(0.5). We therefore weighted the item 7 score by a size effect of 0.5
for both scales.
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