Clinical Profile of an Atypical Antipsychotic: Risperidone
John A. Davis and Nancy Chen

Risperidone dose response

We know that the best-case analysis analyzes the 6 mg dose (the most effective dose of risperidone with these side effects) whereas the worse-case analysis combines the data from 6 mg, 10 mg, and 16 mg. The sigmoid response curve is an increased response paralleling increased dose for the linear portion of the curve, but then improvement maximizes out and becoming a classic S-shaped curve asymptotes to a maximal improvement. All drugs obey the classical dose-response S-shaped curve, although it is certainly possible that therapeutic windows can occur when too high a dose actually has less therapeutic response. The 6 mg produces slightly more improvement than the 10-16 mg doses on almost all individual items. This effect is just statistically significant for PANSS total score. The better response in the 6 mg dose is most signification the impulsive/hostility factor and the anxiety/depression factor, but as it is present in almost all items we feel evidence is lacking to argue that it is specific to just those items or factors. The PANSS total score and five factors results are posted on our website in Figures 1a-c. Also posted is the rate of improvement for all the individual dose groups.