Meta-analysis of the PANSS total and five factor scores of
risperidone versus haloperidol

Our finding that risperidone produced a better response on all five factors of the PANSS has been replicated by Csernansky and Okamoto (2000). We did a meta-analysis of our five factor results and that of Czernansky and Okamoto based on the Hedges-Olkin (1985) algorithm using Comprehensive Meta Analysis (1.0.16; Borenstein and Rothstein 1999), finding risperidone unequivocally and clearly statistically significantly superior to haloperidol on all five factors.

	Combined P-Value
Total	0.00004
Negative Symptoms	0.00145
Positive Symptoms	0.00099
Disorganized Thoughts	0.00002
Impulsivity/Hostility	0.00028
Anxiety/Depression	0.00007

References:
Borenstein, M., and Rothstein, H. Comprehensive Meta-analysis: A computer program for research synthesis. Englewood, N.J.: Biostat, 1999.

Csernansky, J., and Okamoto, A. Risperidone vs haloperidol for prevention of relapse in schizophrenia and schizoaffective disorders: a long-term double-blind comparison. 55th Annual Scientific Convention and Program of the Society of Biological Psychiatry. Chicago, Illinois, 2000.

Hedges, L.V., and Olkin, I. Statistical Methods for Meta-Analysis. Orlando,Fla: Academic Press, 1985.