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Pauline M. Maki, Ph.D. directs a comprehensive clinical research program examining the influence of sex steroid hormones on cognition and brain function. Her clinical trials in midlife women are aimed at comparing the effect of prescription hormone therapy and alternative menopausal therapies on cognition, mood, and brain function. She also investigates changes in cognition across the menstrual cycle and menopausal transition in healthy women, women with HIV, and women with schizophrenia. Her studies using positron emission tomography and functional magnetic resonance imaging have demonstrated that estrogen therapy targets hippocampus, frontal lobes, and other brain regions subserving memory function. With colleagues at the National Institute on Aging and the Wake Forest University School of Medicine Dr. Maki helped to spearhead and serves as a co-Principal Investigator in two large multisite randomized clinical trials - the Women’s Health Initiative Study of Cognitive Aging and the Study of Tamoxifen and Raloxifene.
Representative publications
Maki, P.M. (in press) Hormone Therapy and Risk for Dementia: Where do we go from here? Gynecological Endocrinology.
Resnick, S.M, Maki, P.M., Rapp, S.R., Espeland, M.A., & Shumaker, S.A (in press). The Women's Health Initiative Study of Cognitive Aging (WHISCA): A randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline, Clinical Trials.
Maki, P.M. and Hogervorst, E. (2003) HRT and cognitive decline. Balliere’s Best Practice and Research: Clinical Endocrinology & Metabolism, 17,105-22.
McLay, R.N., Maki, P.M., and Lyketsos, C.G. (2003) Nulliparity and late menopause are associated with decreased cognitive decline Journal of Neuropsychiatry and Clinical Neurosciences, 15, 61-67.
Maki, P. M. (2002). Re: Prospective Assessment of Estrogen Replacement Therapy and Cognitive Functioning: Atherosclerosis Risk in Communities Study. American Journal of Epidemiology, 156, 785.
Maki, P.M., Rich, J.B., & Rosenbaum, R.S. (2002). Implicit memory varies across the menstrual cycle: Estrogen effects in young women. Neuropsychologia, 40, 518-529.
Maki, P.M., Zonderman, A.B., & Resnick, S.M. (2001). [extended abstract] Enhanced verbal memory in nondemented elderly estrogen users, Menopause Digest, 13, 11-12.
Maki, P.M., Resnick, S.M. (2001). Effects of estrogen on patterns of brain activity at rest and during cognitive activity: A review of neuroimaging studies. NeuroImage, 14, 789-801.
Resnick, S.M. & Maki, P.M. (2001). Effects of hormone replacement therapy on cognitive and brain aging. Annals of the New York Academy of Sciences, 949, 203-214.
Maki, P.M., Zonderman, A.B., & Resnick, S.M. (2001). Enhanced verbal memory in nondemented elderly estrogen users, American Journal of Psychiatry, 158, 227-233.
Yaffe, K., Maki, P.M., & Schmidt, P. (in press) What’s after Estrogen? SERMs: A review of basic and clinical data on the effects of SERMs on cognition. In Rasgon N. (Eds.) Estrogen's effects on brain function. What's next?
Maki, P.M. Resnick, S.M. (2004). Effects of Hormone Therapy on Patterns of Brain Activation during Cognitive Activity: A Review of Neuroimaging Studies In Bergemann N, Resch F, Riecher-Rössler (Eds). Estrogen Effects on Psychiatric Diseases. Springer.
Maki, P.M. (2003). Methodological pitfalls in the study of estrogen on cognition and brain function. In A. Genazanni (Ed.) Hormone Replacement Therapy and Neurological Function. Parthenon. |
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