Geriatric Pharmacodynamics: Action of Drugs on the Body
Dopamine D2 decreased in the striatum
Cholinergic System
- Choline acetyltransferase decreased
- Cholinergic cell numbers decreased
Adrenergic System
- Beta-adrenoceptor numbers decreased
- Alpha2-adrenoceptor responsiveness decreased
Gabaminergic System
- Postsynaptic receptor response to GABA increased