University of Illinois at Chicago
Department of Psychiatry
1601 W. Taylor Street, (M/C 912)
Chicago, IL 60612
Office Phone: (312) 413-3970
Matrisciano F, Dong E, Nicoletti F, Gavin DP, Guidotti,A. Activation of Group II Metabotropic Glutamate Receptors Increases the Expression of Gadd45b: A Molecular Player in Active DNA Methylation. Biological Psychiatry, submitted.
Guidotti A, Auta J, ChenY, Davis JM, Dong E, Gavin DP, Grayson DR, Matrisciano F, Pinna G, Satta R, Sharma RP, Tremolizzo L, Tueting P. Epigenetic GABAergic Targets in Schizophrenia and Bipolar Disorder. Neuropsychopharmacology, submitted
Dong E, Chen Y, Gavin DP, Grayson DR, Guidotti A. Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics 5(8), 2010.
Sharma RP, Gavin DP, Grayson DR. CpG methylation in neurons: message, memory, or mask? Neuropsychopharmacology 35(10): 2009-20, 2010.
Gavin DP, Sharma RP. Histone modifications, DNA methylation, and schizophrenia. Neuroscience & Biobehavioral Reviews 34(6):882-8, 2010.
Gavin DP, Sharma RP. Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia. Cardiovascular Psychiatry and Neurology. 2009;2009:409562.
Gavin DP, Kartan S, Chase K, Jayaraman S, Sharma RP: Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population. Journal of Psychiatric Research 43(9):870-6, 2009.
Gavin DP, Rosen C, Chase K, Grayson DR, Sharma RP: Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to HDAC inhibitors in lymphocyte cultures. Journal of Psychiatry and Neuroscience 34(3):232-7, 2009.
Imbesi M, Arslan AD, Yildiz S, Sharma R, Gavin D, Tun N, Manev H, Uz T: The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal 'clock' gene expression in striatal neurons in vitro. Journal of Pineal Research 46(1): 87-94, 2009.
Gavin DP, Kartan S, Chase K, Grayson DR, Sharma RP: Reduced acetylated histone 3 levels and a blunted response to HDAC inhibition in lymphocytes from schizophrenia subjects. Schizophrenia Research 103(1-3): 330-2, 2008.
Sharma RP, Grayson DR, Gavin DP: Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection. Schizophrenia Research 98(1-3): 111-7, 2008.
David P. Gavin, MD
Research Assistant Professor
Dr. Gavin is a psychiatrist with an interest in studying gene regulatory mechanisms in psychosis. He graduated with honors from the University of Chicago with a BA degree in Biology and a specialization in Molecular Genetics and Cellular Biology. He earned an MD degree from the University of Illinois at Chicago. He remained at the University of Illinois at Chicago during his psychiatry residency training where he participated in the Adult Psychiatry Neuroscience Research Track.
His research involves studying epigenetic mechanisms using both clinical models, such as patient peripheral blood cells, and basic models, such as cultured mouse neurons. One aim of this research is to translate findings of gene regulatory abnormalities in schizophrenia into clinically useful tools to predict treatment response and develop novel therapeutics. This research has been presented at several international conferences and published in peer-reviewed journals.
Elucidating factors that control gene expression as they relate to cognition and perception. The ultimate goal of these projects is the rapid application of basic scientific findings to diagnostic, prognostic, and treatment use in patients.