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CONTACT INFORMATION

900 S. Ashland Ave. Room 1006
Chicago, IL 60607

Office Phone: 312-413-2599
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KEY PUBLICATIONS

Liu C (2011): Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases. Neuroscience Bulletin. 27(2):123-33.

Alliey-Rodriguez N, Zhang D, Badner JA, Cheng L, Pibiri F, Grennan K, Chen C, Chen Q, Qian Y, Zhang X, Dinwiddie S, Romanos B, Plenys N, Liu C, Gershon ES, The Bipolar Genome Study (online): GWAS for Personality Traits in Bipolar Patients. Psychiatr Genet.

Chen C, Grennan K, Badner JA, Jin L, Gershon ES, Liu C (online): Removing batch effects in analysis of expression microarray data: an evaluation of six batch adjustment methods. PLoS One.

Gershon ES, Alliey-Rodriguez N, Liu C (online): Genome-Wide Association Studies of Bipolar Disorder and Schizophrenia: Not All We Hoped For. Am J of Psychiatry.

Zhang D, Qian Y, Akula N, Alliey-Rodriguez N, Tang JT, BiGS, Gershon ES, Liu C (2011): Accuracy of CNV Detection from GWAS Data. PLoS One 6(1):e14511.

Liu C, Cheng L, Badner JA, Zhang D, Craig DW, Redman M, Gershon ES (2010): Whole-genome association mapping of gene expression in the human prefrontal cortex. Mol Psychiatry 15: 779-784.

Piletz JE, Zhang X, Ranade R, Liu C (2010): Database of genetic studies of bipolar disorder. Psychiatr Genet.

Zhang D, Cheng L, Badner JA, Chen C, Chen Q, Luo W, Craig DW, Redman M, Gershon ES, Liu C (2010): Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 86: 411-419.

Maheshwari M, Shi J, Badner JA, Skol A, Willour VL, Muzny DM, Wheeler DA, Gerald FR, Detera-Wadleigh S, McMahon FJ, Potash JB, Gershon ES, Liu C, Gibbs RA (2009): Common and rare variants of DAOA in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 150B: 960-966.

Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Eskin E, Foroud T, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Murray SS, Nievergelt C, Nurnberger J, Nwulia EA, Paschall J, Potash JB, Rice J, Schulze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Zollner S, Schork NJ, Kelsoe JR (2009): Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 14: 755-763.

Zhang D, Cheng L, Qian Y, Aliey-Rodriguez N, Kelsoe JR, Greenwood T, Nievergelt C, Barrett TB, McKinney R, Schork N, Smith EN, Bloss C, Nurnberger J, Edenberg HJ, Foroud T, Sheftner W, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze TG, Berrettini W, Potash JB, Belmonte PL, Zandi PP, McInnis MG, Zollner S, Craig D, Szelinger S, Koller D, Christian SL, Liu C, Gershon ES (2009): Singleton deletions throughout the genome increase risk of bipolar disorder. Mol Psychiatry 14: 376-380.

Shi J, Badner JA, Gershon ES, Liu C (2008): Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophr Res 98: 89-97.

Shi J, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C (2008): Neurotransmission and bipolar disorder: a systematic family-based association study. Am J Med Genet B Neuropsychiatr Genet 147B: 1270-1277.

Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C (2008): Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet 147B: 1047-1055.

Shi J, Gershon ES, Liu C (2008): Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res 104: 96-107.

Liu C, Shi J, Badner JA, Zou H, Qian Y, Gershon ES (2007): No association of trace amine receptor genes with bipolar disorder. Mol Psychiatry 12: 979-981.

Shi J, Hattori E, Zou H, Badner JA, Christian SL, Gershon ES, Liu C (2007): No evidence for association between 19 cholinergic genes and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 144B: 715-723.

Yao F, Zhang R, Zhu Z, Xia K, Liu C (2006): MutScreener: primer design tool for PCR-direct sequencing. Nucleic Acids Res 34: W660-W664.

Hattori E, Liu C, Zhu H, Gershon ES (2005): Genetic tests of biologic systems in affective disorders. Mol Psychiatry 10: 719-740.

Zhang R, Zhu Z, Zhu H, Nguyen T, Yao F, Xia K, Liang D, Liu C (2005): SNP Cutter: a comprehensive tool for SNP PCR-RFLP assay design. Nucleic Acids Res 33: W489-W492.

Nguyen TH, Liu C, Gershon ES, McMahon FJ (2004): Frequency Finder: a multi-source web application for collection of public allele frequencies of SNP markers. Bioinformatics 20: 439-443.

Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (2003): Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72: 1131-1140.

Liu C, Bonner TI, Nguyen T, Lyons JL, Christian SL, Gershon ES (2003): DNannotator: Annotation software tool kit for regional genomic sequences. Nucleic Acids Res 31: 3729-3735.

Chunyu Liu, Ph.D

Visiting Associate Professor

Dr. Liu has a long-term interest in understanding of molecular basis of psychiatric diseases. His laboratory participated one of the bipolar genetics research consortiums and discovered the rare copy number variant (CNV) burden in early-onset bipolar disorder. His lab is one of the leading research groups on genome-wide study of postmortem brain gene expression and DNA methylation. He established the methylation quantitative trait loci (mQTLs) in human brain, indicating that DNA methylation of some sequences could be highly regulated by genetic variants. His research has been supported by NIMH, NARSAD, and Brain Research Foundation. He has published more than 50 peer-reviewed papers and several book chapters.

Interests:
Dr. Liu’s major research focuses on using a comprehensive approach that is composed of genetics, bioinformatics, genomics, and animal models to identify the molecular mechanisms of major psychiatric diseases, particularly bipolar disorder and schizophrenia.

Affiliations/Memberships:
American Society of Human Genetics
Society of Biological Psychiatry
International Society of Psychiatric Genetics

 
Projects:
  1. MicroRNA in bipolar disorder and schizophrenia: looking for variants in miRNAs that might be related to the diseases;
  2. Gene expression regulation in human brain: map genetic/epigenetic regulators in brain;
  3. CNVs and SNPs in whole genome association study of bipolar disorder: looking for SNP/CNV association with the disease;
  4. G72 transgenic mice: study biochemical, genomic, and behavioral changes in a human BAC transgenic mice that may serve as a model for human psychiatric diseases.
  5. Bioinformatics: develop software/databases to support high-throughput data analysis and integration of genomic/eipgenomic/genetic/phenotypic data.

 

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