Department of Psychiatry
University of Illinois at Chicago
1601 W Taylor Street (M/C 912)
Chicago, IL 60612
Office Phone: 312-355-2348

Zheng Y, Fan W, Zhang X, Dong E.* Gestational Stress Induces Depression-like and Anxiety-like Phenotypes through Epigenetic Regulation of BDNF Expression in Offspring Hippocampus, Epigenetics (2016)11(2):150-62 (* corresponding author)

Dong E, Tueting P, Matrisciano F, Grayson DR, Guidotti A. Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs. Translational Psychiatry (2016) 12;6:e711.

Labouesse MA, Dong E, Grayson DR, Guidotti A, Meyer U. Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex. Epigenetics (2015) 10(12):1143-55

Dong E., Ruzika WB., Grayson DR., Guidotti A.: DNA-methyltransferase 1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in brain of schizophrenia and bipolar disorder patients. Schizophr Res (2015) pii: S0920-9964(14)00599-4

Dong E.*, Dzitoyeva S., Matrisciano F., Tueting P., Grayson DR., Guidotti A.: BDNF epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice. Biol Psych (2015) 77(6):589-596 (* corresponding author)

Zhubi A., Chen Y., Dong E., Cook EH., Guidotti A., Grayson DR.: Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl Psychiatry (2014) 21;4:e349

Auta J., Smith RC., Dong E., Tueting P., Sershen H., Boules S., Lajtha A., Davis JM., Guidotti A.: DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients. Schizophr Res (2013) 150(1):312-318

Guidotti A., Dong E., Gavin DP., Veldic M., Zhao W., Bhaumik DK., Pandey SC., Grayson DR.: DNA methylation/demethylation network expression in psychotic patients with a history of alcohol abuse. Alcohol Clin Exp Res (2013) 37(3):417-424

Dong E.*, Gavin DP., Chen Y., Davis JM.: Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients. Transl Psychiatry (2012) 4;2:e159

Gavin DP., Sharma RP., Chase KA., Matrisciano F., Dong E., Guidotti A.: Growth arrest and DNA-damage-inducible, beta (GADD45b)-mediated DNA demethylation in major psychosis. Neuropsychopharmacology (2012) 37(2):531-542

Matrisciano F., Dong E., Gavin DP., Nicoletti F., Guidotti A.: Activation of group II metabotropic glutamate receptors promotes DNA demethylation in the mouse brain. Mol Pharmacol (2011) 80(1):174-182

Chen Y., Dong E., Grayson DR.: Analysis of the GAD1 promoter: trans-acting factors and DNA methylation converge on the 5'untranslated region. Neuropharmacology (2011) 60(7-8):1075-1087

Dong E.*, Chen Y., Gavin DP., Grayson DR., Guidotti A.: Valproate induces DNA demethylation in nuclear extracts from adult mouse brain. Epigenetics (2010) 22;5(8):730-735 (* corresponding author)

Dong E., Nelson M., Grayson DR., Costa E., Guidotti A.: Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proc Natl Acad Sci USA (2008) 105(36):13614-13619

Dong E., Guidotti A., Grayson DR., Costa E.: Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc Natl Acad Sci USA (2007) 104(11):4676-4681

Simonini MV., Camargo ML., Dong E., Maloku E., Jones P., Veldic M., Guidotti A., Costa E.: The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases Proc Natl Acad Sci USA (2006) 103 (5):1587-1592

Dong E., Agis-Balba R., Simonini MV., Grayson DR., Costa E., Guidotti A.: Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia Proc Natl Acad Sci USA (2005) 102 (35):12578-12583

Tremolizzo L., Doueiri MS., Dong E., Grayson DR., Davis JM., Pinna G., Tueting P., Rodriguez-Menendez V., Costa E., Guidotti A.: Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry (2005) 57 (5):500-509

Pinna G., Dong E., Matsumoto K., Costa E., Guidotti A.: In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proc Natl Acad Sci USA (2003)100(4):2035-2040

Dong E., Caruncho H., Liu WS., Smalheiser NR., Grayson DR., Costa E., Guidotti A.: Reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proc Natl Acad Sci USA (2003) 100(9):5479-5484

Dong E., Matsumoto K., Watanabe H.: Diazepam binding inhibitor (DBI) reduces testosterone and estradiol levels in vivo. Life Sci (2002) 70(11):1317-1323

Dong E., Matsumoto K., Uzunova V., Sugaya I., Watanabe H., Costa E. and Guidotti A.: Brain 5a-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci USA (2001) 98(5):2849-2854.

Dong E., Matsumoto K., Toda M., Kaneko Y., and Watanabe H.: Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice. Neuro Res (1999) 33(3):171-177

Dong E., Matsumoto K., Toda M., and Watanabe H.: Possible involvement of diazepam binding inhibitor and its fragment octadecaneuropeptide in social isolation stress-induced decrease in pentobarbital sleep in mice. Life Sci (1999) 64(19):1779-1784

Dong E., Matsumoto K., Toda M., Kaneko Y., and Watanabe H.: Involvement of peripheral type of benzodiazepine receptor in social isolation stress-induced decrease in pentobarbital sleep in mice. Life Sci (1999) 65(15):1561-1568

(* corresponding author)

Erbo Dong, PhD

Associate Professor (rt)

Dr. Dong’s research has concentrated on furthering understanding the role of epigenetic mechanisms in the development of major psychosis, focusing especially on the epigenetic modifications of GABAergic and glutamatergic genes observed in the psychotic brains.

Preclinical models of mental disorders
Biomarkers of mental disorders
Long non-coding and microRNAs in psychiatric disorders
The complex interplay between stress and pathophysiological transformations associated with alcohol intake and comorbid disorders and possible pharmacological intervention.

Society for Neuroscience




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