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CONTACT INFORMATION
820 South Damen Avenue
Taylor Pavilion (7th Floor) Rm 7298
Jesse Brown VA Medical Center,
Chicago, IL 60612
Office Phone: (312) 569-7425
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KEY PUBLICATIONS

Moonat S, Starkman BG, Sakharkar A, Pandey SC. 2010. Neuroscience of alcoholism: molecular and cellular mechanisms. Cellular and Molecular Life Sciences 67:73-88.

Moonat S, Sakharkar A, Zhang H, Pandey SC. 2010. The role of amygdaloid brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein and dendritic spines in anxiety and alcoholism. Addiction Biology 16:238-550.

Zhang H, Sakharkar AJ, Shi G, Ugale R, Prakash A, Pandey SC. 2010. Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. Alcoholism: Clinical and Experimental Research 34:451-461.

Starkman BG, Sakharkar AJ, Pandey SC. 2011. Epigenetics-Beyond the genome in alcoholism. Alcohol Research and Health – Official Journal of National Institutes of Health (NIH)-National Institute on Alcohol Abuse and Alcoholism (USA) (NIAAA) 34:293-305.

Sakhakar AJ, Tang L, Zhang H, Shi G, Pandey SC. 2012. Histone deacetylases (HDAC)-induced chromatin remodeling in amygdala: A role in rapid tolerance to anxiolytic effects of alcohol. Alcoholism: Clinical and Experimental Research 35:1-11.

Kalinin S, Polak PE, Lin SX, Sakharkar AJ, Pandey SC, Feinstein DL. 2012. The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer’s disease. Neurobiology of Aging 33:1651-1663.

Moonat S, Sakharkar AJ, Zhang H, Tang L, Pandey SC. 2013. Histone deacetylase 2-induced chromatin remodeling in the amygdala of P rats plays major role in its genetic predisposition to anxiety and alcoholism. Biological Psychiatry 73:763-773.

Arora DS, Nimitvilai S, Teppen TL, McElvain MA, Sakharkar AJ, You C, Pandey SC, Brodie MS. 2013. Hyposensitivity to aamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. Neuropsychopharmacology 38:1674-1684.

Zhang X, Kusumo H, Sakharkar AJ, Pandey SC, Guizzetti M. 2013. Epigenetic regulation of DNA methylation by ethanol induces Tissue Plasminogen Activator expression in astrocytes. Journal of Neurochemistry (In Press)

You C, Zhang H, Sakharkar AJ, Teppen T, Pandey SC. 2013. Reversal of deficits in dendritic spines, BDNF, and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. International Journal of Neuropsychopharmacology (In Press)

Sakharkar AJ, Zhang H, Tang L, Baker K, Shi G, Moonat S, Pandey SC. 2013. Effects of Histone Deacetylase Inhibitors on Amygdaloid Histone Acetylation and Neuropeptide Y Expression: A Role in Anxiety-like and Alcohol Drinking Behaviors. International Journal of Neuropsychopharmacology (Under Minor Revision).

Amul J Sakharkar, PhD

Research Assistant Professor

Dr. Sakharkar has been working in the field of epigenetics of the alcohol use disorders using rodent animal models. He is actively involved in investigating different epigenetic mechanisms e.g. histone acetylation/deacetylation, DNA methylation/demethylation, that are operative in the impact of adolescent drinking on alcohol abuse at adulthood

Interests:

Neurobiology of Alcoholism
Epigenetics of Neurobiological Disorders

Affiliations/Memberships:

Research Society for Alcoholism, USA

Projects:

Role of adolescent intermittent ethanol drinking in epigenetics and behavioral changes at adulthood

 

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